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Nemours Center for Childhood Cancer Research Receives Over $1 Million in Grants for Cancer Research in 2008
Date:1/8/2009

ls available for children with cancer in the State of Florida. Currently, there is no Phase I cancer center for children in Florida. As a result, Florida children eligible for such studies must go out of state. In conjunction with the Moffitt Cancer Center, All Children's Hospital and the Florida Sunshine Project, Nemours is opening several studies of experimental cancer treatments that will be available to children in Florida.

Sigrid A. Rajasekaran, PhD, was awarded a four-year $720,000 grant from the American Cancer Society to study the mechanism of increased function of growth factors in cancer cells. Growth factors and their binding partners called receptors are increased in a wide spectrum of human cancers, including bladder cancer, renal carcinoma, lung cancer, and brain tumors such as glioblastoma and childhood tumors such as medulloblastoma. In several tumor types, increased receptor levels correlate with poor prognosis. Therefore, growth factor receptors are a promising target for cancer therapy. There are several ongoing clinical trials in various institutions using inhibitors of various growth factor receptors to stop the growth of cancer cells. The project funded by the American Cancer Society will study the molecular mechanism by which ionic imbalance contributes to growth factor receptor activation in cancer cells. Findings should provide new insights into novel therapeutic approaches to target growth factor receptors in cancer cells.

Robert W. Mason, PhD, was awarded a 2-year $200,000 grant from the Alex's Lemonade Stand Foundation to study a new approach to treat neuroblastoma, a common childhood cancer that is very difficult to treat when discovered in children older than 2 years of age. The treatments that are being used today are the same as those used to treat adult cancers and unfortunately they do not work well. Dr. Masons's laboratory discovered a compound that could destroy neuroblastoma cells without affecting other ra
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Nemours Center for Childhood Cancer Research Receives Over $1 Million in Grants for Cancer Research in 2008 
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