Navigation Links
Necrostatin-1 counteracts aluminum's neurotoxic effects
Date:8/5/2013

Amsterdam, NL, August 2, 2013 Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer's disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum's neurotoxic effects.

Researchers have long focused on why neurons die in degenerative diseases. One process is apoptosis, a form of gene-directed programmed cell death which removes unnecessary, aged, or damaged cells. When neurons die as a result of stroke, trauma, or other insult, the process is known as necrosis. Recently, a new type of necrosis, necroptosis (programmed necrosis), has been implicated in the cell demise process. In this report, the results of several experiments support the hypothesis that aluminum-induced neuronal cell death is, to a large extent, due to necroptosis, says lead investigator Qinli Zhang, PhD, of the Department of Occupational Health, Ministry of Education Key Laboratory, School of Public Health of Shanxi Medical University in Taiyuan China.

For instance, when aluminum was added to mouse cortical neurons grown in cell culture, the cells began to die. By adding inhibitors of apoptosis (zVAD-fmk), of autophagy (3-methyladenin, 3-MA), or of necroptosis (necrostatin-1, Nec-1), investigators showed that all treatments enhanced cell viability although Nec-1 demonstrated the strongest protection. Using fluorescent microscopy, in which surviving neural cells stain green, apoptotic cells stain orange, and necrotic cells stain red, the investigators demonstrated Al-induced cell death as well as dose-dependent reduction of necroptosis with Nec-1.

When aluminum was injected into the cerebral ventricles of living mice, brain tissue analysis revealed shrunken and abnormal-looking neurons. When Nec-1 was i
'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Acai counteracts oxidative stress, lengthens lifespan in fruit flies
2. Young girls more likely to report side effects after HPV vaccine
3. Preteens More Likely to Report HPV Vaccine Side Effects
4. Breast cancer patients suffer treatment-related side effects long after completing care
5. Breast Cancer Treatment Side Effects May Last for Years
6. Baldness Drug May Cause Sexual Side Effects: FDA
7. Study examines adverse effects among different radiation therapies for prostate cancer
8. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
9. Moffitt researcher publishes book on nutritional management of cancer treatment effects
10. Researchers see BPA effects in monkey mammary glands
11. Many Primary Care Docs Dont Know Long-Term Effects of Chemo: Survey
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... Viejo, California (PRWEB) December 20, 2014 ... announced the release of a new plugin for Final ... Film Studios. , “TranSlice Volume 5 allows users to ... hand draw it.” Said Christina Austin, CEO of Pixel ... add level of professionalism while maintaining an easy to ...
(Date:12/20/2014)... The Twin Cities DI Day is recognized as the ... 250 financial professionals come together each year to hear ... motivated to protect their clients and to be inspired ... challenges of disability. , On September 23rd, 2014, financial ... attend The 13th Annual Twin Cities DI Day where ...
(Date:12/20/2014)... Balfleet.com, one of the most outstanding dressmakers in the ... its Mother of the Bride Dresses in ... dresses from Balfleet.com feature gorgeous looks and delicate craftsmanship. ... in providing high quality dresses to its clients with ... our mother of the bride dresses, and we hope ...
(Date:12/19/2014)... (PRWEB) December 20, 2014 It’s very easy ... is something that is put to the wayside until Christmas ... still have that travel “itch” and that burning desire to ... accommodates families on their journey to Telluride with a no-fuss, ... visitors to and from the resort, and ensure that all ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Sub Zero Ice ... sponsor a blood drive Sunday the 28th from 2pm-6pm at ... & Sawyer Road in Sarasota, FL. , Inquiries regarding time ... you for participating in the donating process, Sub Zero Ice ... flash frozen, custom ice cream. , About Sub Zero Ice ...
Breaking Medicine News(10 mins):Health News:Pixel Film Studios released a new transition entitled TranSlice Volume 5 exclusively for Final Cut Pro X 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2Health News:Days Inn Montrose Colorado Delivers Last Minute Holiday Season Ski Getaway Accommodations 2Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2
... April 25, 2012 Preliminary Research presented today ... Biology (FASEB) Conference in San Diego demonstrates that ... mashed) is not associated with obesity, type 2 ... of systemic inflammation once potential confounding factors are ...
... be able to access hidden wisdom in the brain ... and safety, UCLA neuroscientists report in the first study ... will respond to advertisements. Thirty smokers ... three advertising campaigns, which all ended by showing the ...
... life and death for very low birth weight infants, according ... Nursing and released today in JAMA , The ... comprehensive study of 72,235 infants born in 558 hospitals across ... hospitals with the Magnet credential were less likely to die, ...
... a bit of a puzzle. Representing only 10 percent of ... and persecuted across history. The word "sinister" even derives from ... report that a high degree of cooperation, not something odd ... left-handedness. They developed a mathematical model that shows the low ...
... April 25 (HealthDay News) -- A lack of support following ... a loved one, abuse and sexual assault can trigger eating ... disorders said even changing schools or jobs could trigger eating ... of Minnesota researchers. The study included 26 women and ...
... Reporter , WEDNESDAY, April 25 (HealthDay News) -- So, what ... as in Holy Grail, because a Florida gynecologist contends that he ... Dr. Adam Ostrzenski said, he located the elusive source of female ... a paper published online April 25 in The Journal of ...
Cached Medicine News:Health News:Which ads are winners? Your brain knows better than you do 2Health News:Which ads are winners? Your brain knows better than you do 3Health News:Which ads are winners? Your brain knows better than you do 4Health News:Choosing the right hospital may save your baby's life 2Health News:Shedding light on southpaws 2Health News:Life Transitions May Trigger Eating Disorders 2Health News:Has the 'G-Spot' Been Confirmed at Last? 2Health News:Has the 'G-Spot' Been Confirmed at Last? 3
(Date:12/19/2014)... Fla. , Dec. 19, 2014 Breckenridge ... a multi-product agreement with MSN Laboratories Pvt. Ltd. ( ... MSN expect to commercialize several new ANDAs.  Under the ... supply the products exclusively to Breckenridge for the U.S. ... under its label.  Breckenridge and MSN have agreed to ...
(Date:12/19/2014)... CARDIFF-BY-THE-SEA, Calif. , Dec. 19, 2014 ... ;  Sorrento), an oncology company developing new treatments ... a privately-held immuno-oncology company developing proprietary Neukoplast ® ... therapy, announced today that the companies have entered ... generation CAR-TNK™ (pronounced as "Car-Tank") immunotherapies for the ...
(Date:12/19/2014)... BURLINGTON, Mass. , Dec. 18, 2014  Decision ... the United States will increase ... Growth will be primarily driven by expansion in the ... direct energy devices will be increasingly adopted due to ... launched. Other key findings from Decision Resources ...
Breaking Medicine Technology:Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3
... 10, 2012 Cyberonics, Inc. (NASDAQ: CYBX ), ... management of epilepsy, today announced it will participate in the ... 2012, in New York. Greg Browne, Senior Vice ... Eastern Time.  A live audio webcast of the presentation can ...
... Feb. 10, 2012  Zacks highlights commentary from People and Picks ... http://photos.prnewswire.com/prnh/20101027/ZIRLOGO ) For more Voice of the People, ... Market Percolates, Doubters Wait They,re coming ... course the troll community. They,re telling you the market is ...
Cached Medicine Technology:Zacks' Voice of the People highlights opportunities with Walgreen, Occidental Petroleum and Brown & Brown 2Zacks' Voice of the People highlights opportunities with Walgreen, Occidental Petroleum and Brown & Brown 3
... mg/kg sulfate (SO 4 ) ≤ 1000 mg/kg Cation ... Co ≤ 5 mg/kg Cr ≤ 10 mg/kg Cu ... 5 mg/kg Mg ≤ 5 mg/kg Mn ≤ 5 ... Pb ≤ 5 mg/kg Zn ≤ 5 mg/kg Special ...
Application: Capable of separating DNA fragments of 50 to 1000 bp on a 3% gel Solubility: water 15 mg/mL, clear, colorless, hot Special grade: for molecular biology Suitab tst: electrophoresis te...
Inquire...
Inquire...
Medicine Products: