Navigation Links
Nature publication on pain research
Date:1/22/2008

Our bodies sense painful stimuli through certain receptors located in the skin, in joints and many internal organs. Specialized nerve fibers relay these signals coming from the periphery to the brain, where pain becomes conscious. The spinal cord is placed between these structures as kind of a pain filter, says Hanns Ulrich Zeilhofer, Professor at the Institute of Pharmaceutical Sciences at ETH Zurich and at the Institute of Pharmacology and Toxicology of the University of Zurich.

That filter assures that pain is not evoked by everyday stimuli like light touch. This is accomplished by inhibitory nerve cells located in the spinal dorsal horn that release the messenger molecule -amino butyric acid (GABA) at specialized contacts between neighboring nerve cells, so-called synapses. GABA then acti-vates chloride channels on those neighboring cells which relay the pain signals to the brain.

Activating pain inhibiting factors

In patients with chronic inflammatory diseases, such as rheumatoid arthritis or after nerve damage, for example following injuries, the pain inhibiting action of GABA becomes severely compromised. Pain signals are then conducted to the brain nearly unfiltered. Benzodiazepines, such as the sedative drug Valium, which enhance the action of GABA, alleviate chronic pain when they are applied directly to the spinal cord via an injection into the spinal canal. In practice, how-ever, such injections can only be done in very selected cases. More often benzodiazepines are administered systemically, such as with tablets. In this instance, the benzodiazepines not only act in the spinal cord but also in the brain where they can have undesired, sometimes deleterious, effects on pain patients. The drugs cause sedation, impair memory, and can even lead to addiction. In addition, during prolonged treatment their effect often fades with time. Classic benzodiazepines should therefore be avoided in chronic pain patients.'/>"/>

Contact: Professor Hanns Ulrich Zeilhofer
hansze@ethz.ch
41-044-635-5912
ETH Zurich/Swiss Federal Institute of Technology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gene signature spells poor outcome
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. Revealing the workings of Mother Natures blowtorch
4. APHA Urges President Bush Not To Veto CHIP; Were Only One Signature Away from Protecting the Health of Our Children
5. DuPont Pledges $250,000 to Nature Conservancy for Water Quality Initiative
6. Natures Baby Organics Announces Ah-Choo! Chest Rub
7. National Nature Made(R) Survey Finds U.S. Adults Are Concerned About Heart Disease but May not be Managing Their Risk
8. New neuroimaging study identifies brain signature for cigarette cravings
9. Hays AG Integrates Authentidate(R) Signature Solution for Electronic Invoicing
10. Open access to health research publications
11. Elbit Medical Imaging Ltd. Announces Publication of a Prospectus in Israel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... D.C. (PRWEB) April 25, 2015 The ... Bangladesh Worker Safety issues the following statement following the ... earthquake hit Kathmandu, Nepal, resulting in the deaths of ... massive earthquake were felt across Nepal, Bangladesh, India and ... offer my heartfelt condolences to the people of Nepal ...
(Date:4/25/2015)... Carinsurancequotesinfo.com has released a new blog ... auto insurance for flatbed trucks. , Flatbed ... other vehicles. They are mainly used for commercial purposes ... blog post explains that by comparing multiple offers, drivers ... other commercial vehicles. , It is now possible to ...
(Date:4/25/2015)... Caicos Islands, BWI (PRWEB) April 25, 2015 ... (PLS) has celebrated three months of successfully welcoming visitors ... January 5, 2015. , As part of a ... of Providenciales airport was completely redesigned to speed up ... up the process of getting out of the airport ...
(Date:4/25/2015)... 2015 The URO CENTER of NEW YORK ... chosen by the New York Academy of Medicine to receive ... the field of Urology. , Dr. Ferdinand Valentine, born in ... diseases. He was a man of rare and attractive ... Not only did he devote his life to his ...
(Date:4/25/2015)... April 25, 2015 For thirteen years, the ... income protection education event in the nation! This year, on ... Plus Group, US to take DI Day on the road ... G. Davidson, CLU, ChFC, RHU, DIA, CLTC, Chief Executive Officer ... Day reflects on the change by stating, "The first Twin ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Secura Consultants Takes DI Day On The Road 2
... to reassure people that chicken is safe to eat, U.S. ... that they are free from hazardous forms of avian influenza//. ... farm before the birds are moved to processing plants, under ... trade group. Companies that account for more than 90 percent ...
... as well! The Cell Boom, a boon to communication has ... study.// ,As part of the study, ... for over 2 years. The study revealed a definite decline ... invaded work and home life. The negative impact was perceived ...
... fellow at the Women's and Children's Hospital in Adelaide, Australia ... at birth lead to severe damage of the brain tissue ... conducted in which 443 babies suffering from cerebral palsy were ... very shocking as most of the babies with cerebral palsy ...
... Gujarat Government seeks to bring down infant and mortality rates ... as 5,000 // mothers and 72,000 babies die every ... this new program named Chiranjeevi, the government aims to bring ... one. Similarly, the Health Department expects the infant mortality rate ...
... (CPI-M) and yoga guru Ramdev clashed violently on 5 January ... reported to have raised slogans against the CPI-M MP Brinda ... were laced with animal and human body parts. The police ... forcibly enter the office of the party. ...
... a rare feat, cardio-thoracic surgeons at the Government General ... in a 30-year old woman under 'spinal epidural anesthesia’. ... under general anesthesia. ,This new surgical innovation ... the patient remains conscious during the entire surgery. The ...
Cached Medicine News:Health News:U.S. Chicken Producers to Test Flocks for Bird Flu 2
(Date:4/24/2015)... N.C. , April 24, 2015  New ... ability of consumers to educate themselves about products ... the tools and techniques available to market researchers ... the changing consumer marketplace, it,s imperative that organizations ... to better identify market opportunities, niches and growth ...
(Date:4/24/2015)... MARLBOROUGH, Mass. , April 24, 2015 Boston ... in the Deutsche Bank 40 th Annual Healthcare Conference ... Dan Brennan , executive vice president and chief ... Relations, will participate in a 35-minute question and answer session ... a.m. ET. A live webcast of the presentation ...
(Date:4/24/2015)... , April 24, 2015  Novartis Pharmaceuticals Corporation (NPC) ... second year in a row on the annual DiversityInc Top ... its 2015 Top 50 Companies for Diversity on April 23 ... . NPC also ranked second on the DiversityInc Top ... 10 Companies for Employee Resource Groups list. ...
Breaking Medicine Technology:Pharmaceutical Industry Using New Technologies to Adjust Their Marketing and Research Approaches for Consumers 2Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4
... 2011 /PRNewswire-Asia-FirstCall/ -- American Oriental Bioengineering, Inc. (NYSE: ... company dedicated to improving health through the development, manufacture ... over the counter ("OTC") products, today announced that it ... financial results on Monday, March 14, 2011, after the ...
... China, March 4, 2011 /PRNewswire-Asia-FirstCall/ -- ... WKBT ) ("Weikang" or the "Company"), a ... (TCM), Western prescription and OTC pharmaceuticals and other health ... today announced that the Company will be presenting at ...
Cached Medicine Technology:American Oriental Bioengineering to Announce Fourth Quarter and Full Year 2010 Financial Results on March 14, 2011 2Weikang Bio-Technology to Present at Rodman & Renshaw Annual China Investment Conference 2
... Vitamin D kit is an enzymeimmunoassay for ... hydroxylated metabolites in serum or plasma. Calibrators, ... labelled 25-OH D. The diluted samples are ... with a highly specific sheep 25-OH D ...
... for the control of glucose metabolism. It ... of Langerhans as the precursor, proinsulin, which is ... are secreted in equimolar amounts into the portal ... of two polypeptide chains, the A-chain and B-chain ...
... is an integral part of the enzymatic ... II as well as the degradation of ... ACE is primarily located in endothelial cells. ... parameter for sarcoidosis and myocardial infarction but ...
... Retinol binding Proetin (RBP) is small (21kD) ... complex with pre-albumin in blood but loses ... been deliverd to the target cells. The ... the glomerulus and catabolized in the,renal tubules ...
Medicine Products: