Navigation Links
Nature Reviews Cancer article traces possible role of damaged DNA in tumor development
Date:3/4/2011

Atlanta - DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.

Paul Doetsch, PhD, professor of radiation oncology and biochemistry and associate director for basic research at Emory's Winship Cancer Institute and Damien Brgeon, PhD, at Institut de Gntique et Microbiologie in Paris, have outlined the role this process known as transcriptional mutagenesis might play in tumor development in a Nature Reviews Cancer article published on February 24, 2011.

"The majority of human cells do not multiply continuously but are slow-replicating and devote a large part of their energy to transcription," say the authors. "DNA damage can miscode at the damaged site and produce mutant transcripts. This process is transcriptional mutagenesis and could lead to the production of mutant proteins and may therefore be important in tumor development."

Transcriptional mutagenesis occurs when cells with damaged DNA produce bad messages during transcription, which leads to the creation of mutant proteins. Scientists already have learned that some genetic damages may block the transcription process, which is a signal for DNA repair molecules to move in and correct the mistake. When certain types of DNA damage are present, however, the non-dividing cells are capable of continuing transcription through the damage despite the erroneous coding messages. This problem can be exacerbated when cells have defects for repairing DNA damage.

As Doetsch and Brgeon note, data on this process are accumulating in several laboratories around the world, and evidence is mounting that transcriptional mutagenesis could have an important role in tumor development and other biological outcomes, including the development of drug resistance. However, at this point there is not enough evidence to know the extent to which transcriptional mutagenesis is involved in tumor development.

"One will have to follow the progeny of a single cell to determine whether cancerous growth can be initiated by the transient expression of oncogenic proteins or the disruption of signaling pathways," the authors say. "Future studies addressing these issues will provide additional insights into the mechanisms and consequences of transcriptional mutagenesis and further establish the role of this process in tumor development."


'/>"/>

Contact: Vince Dollard
vdollar@emory.edu
404-778-4580
Emory University
Source:Eurekalert  

Related medicine news :

1. Digital Signatures Presented at Electronic Document Management Conference
2. Natures Peak Products Along With Company President Paul Wilkinson Were Recently Featured on Segment of Lifetime TV Networks Nationally Broadcast Show The Balancing Act
3. Acne is Killed by Using Same Formula that Nature Uses to Keep Our Eyes Free from Bacteria
4. Nature's Aide Vitamins, Inc. Announces a New Science Driven Osteo-Guard Vitamin Formula Designed to Quickly and Safely Halt Bone Deterioration
5. Genentech uses Complete Genomics human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature
6. How to Partner With Nature ~ A Timely New Program
7. Basque researchers apply chemistry to restoration of paintings and dating of signatures
8. Molecular Signatures in Post-Mortem Brain Tissue of Younger Individuals at High Risk for Alzheimer's Disease
9. Spending time in nature makes people feel more alive, study shows
10. Signature Forum Celebrates 10th Anniversary
11. Molecular signatures may aid fight against pediatric liver disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nature Reviews Cancer article traces possible role of damaged DNA in tumor development
(Date:2/22/2017)... , ... February 22, 2017 , ... ANGLESTRONG , ... Angle, is now available on the App Store and Google Play ... apps for the addiction and recovery industry, partnered with Angle to build ANGLESTRONG. The ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... ProGen™ PRP, the latest innovation in the delivery of Platelet Rich Plasma (PRP). ... cardiovascular and pain management, to accelerate tissue synthesis and provide a faster and ...
(Date:2/22/2017)... Staefa, Switzerland (PRWEB) , ... February 22, 2017 ... ... have difficulty hearing and 72 percent of those report that family members or ... those who think they suffer from hearing loss wear hearing aids. One reason, ...
(Date:2/22/2017)... North Carolina (PRWEB) , ... February 22, 2017 , ... ... of cats and 54% of dogs, according to the Association for Pet Obesity Prevention ... disagreed on key pet food issues such as the benefits of corn and grains, ...
(Date:2/22/2017)... ... ... BrightStar Care Charleston , a home care and medical staffing agency, will ... on Aging’s Senior Expo on Thursday, March 23, 2017, at the Omar Convention ... our community. We are thrilled to participate in this event because we believe it ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... India , February 22, 2017 ... Radio Synthesis Modules Market: Global Opportunity Analysis and Industry Forecast, ... worth $20 million in 2015 and projected to reach $32 ... 2016 to 2022. North America accounted ... and unit volumes, whereas Asia-Pacific region ...
(Date:2/22/2017)... A research report by Arcview Market Research focused on cannabis ... changing landscape of the legal market reveals that regulated cannabis sales ... , a 30% increase from 2015. According to the research ... 2021 representing a 26 percent compound annual growth rate. The use ... Canada is gradually becoming more mainstream thanks ...
(Date:2/22/2017)... Feb 22, 2017 Research and Markets has ... & Trends - Industry Forecast to 2025" report to their offering. ... The Global Clot Management ... over the next decade to reach approximately $2.1 billion by 2025. ... for all the given segments on global as well as regional levels ...
Breaking Medicine Technology: