Navigation Links
Nature Reviews Cancer article traces possible role of damaged DNA in tumor development
Date:3/4/2011

Atlanta - DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.

Paul Doetsch, PhD, professor of radiation oncology and biochemistry and associate director for basic research at Emory's Winship Cancer Institute and Damien Brgeon, PhD, at Institut de Gntique et Microbiologie in Paris, have outlined the role this process known as transcriptional mutagenesis might play in tumor development in a Nature Reviews Cancer article published on February 24, 2011.

"The majority of human cells do not multiply continuously but are slow-replicating and devote a large part of their energy to transcription," say the authors. "DNA damage can miscode at the damaged site and produce mutant transcripts. This process is transcriptional mutagenesis and could lead to the production of mutant proteins and may therefore be important in tumor development."

Transcriptional mutagenesis occurs when cells with damaged DNA produce bad messages during transcription, which leads to the creation of mutant proteins. Scientists already have learned that some genetic damages may block the transcription process, which is a signal for DNA repair molecules to move in and correct the mistake. When certain types of DNA damage are present, however, the non-dividing cells are capable of continuing transcription through the damage despite the erroneous coding messages. This problem can be exacerbated when cells have defects for repairing DNA damage.

As Doetsch and Brgeon note, data on this process are accumulating in several laboratories around the world, and evidence is mounting that transcriptional mutagenesis could have an important role in tumor development and other biological outcomes, including the development of drug resistance. However, at this point there is not enough evidence to k
'/>"/>

Contact: Vince Dollard
vdollar@emory.edu
404-778-4580
Emory University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Digital Signatures Presented at Electronic Document Management Conference
2. Natures Peak Products Along With Company President Paul Wilkinson Were Recently Featured on Segment of Lifetime TV Networks Nationally Broadcast Show The Balancing Act
3. Acne is Killed by Using Same Formula that Nature Uses to Keep Our Eyes Free from Bacteria
4. Nature's Aide Vitamins, Inc. Announces a New Science Driven Osteo-Guard Vitamin Formula Designed to Quickly and Safely Halt Bone Deterioration
5. Genentech uses Complete Genomics human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature
6. How to Partner With Nature ~ A Timely New Program
7. Basque researchers apply chemistry to restoration of paintings and dating of signatures
8. Molecular Signatures in Post-Mortem Brain Tissue of Younger Individuals at High Risk for Alzheimer's Disease
9. Spending time in nature makes people feel more alive, study shows
10. Signature Forum Celebrates 10th Anniversary
11. Molecular signatures may aid fight against pediatric liver disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nature Reviews Cancer article traces possible role of damaged DNA in tumor development
(Date:8/27/2015)... , ... August 27, 2015 , ... ... instruments available for quantitative PCR (qPCR) in the last decade. New ... and reduced operating costs. On the flipside, where do lab managers, technicians, and ...
(Date:8/27/2015)... ... August 27, 2015 , ... Allegheny General ... just 20 adult-only medical centers in the United States to receive international recognition ... lungs. The Extracorporeal Life Support Organization (ELSO) , an international consortium of ...
(Date:8/27/2015)... , ... August 27, 2015 , ... The Naderi Center ... be offering Kybella, a cutting-edge, noninvasive procedure to improve submental fat. The first ... provides permanent results without surgery. Dr. Kulak is the only Board Certified surgeon ...
(Date:8/27/2015)... R.I. (PRWEB) , ... August 27, 2015 , ... More ... on a road trip. That’s why Amica Insurance is sharing some tips to help ... of America, about 30 million people travel with pets each year. Amica is sharing ...
(Date:8/27/2015)... London, UK (PRWEB) , ... ... ... Ltd and Black Swan Analysis signed a partnership agreement for quality market ... sell research reports elaborated by Black Swan Analysis. , Commenting on the ...
Breaking Medicine News(10 mins):Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 2Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 3Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 2Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 3Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 4Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 3Health News:Amica Unleashes 5 Tips for Safe Traveling with Pets 2Health News:Market Publishers Ltd and Black Swan Analysis Sign Partnership Agreement 2Health News:Market Publishers Ltd and Black Swan Analysis Sign Partnership Agreement 3
... treatments can be the worst news a cancer patient ... of Missouri-Columbia is working steadfastly to learn why some ... drug cisplatin, in hopes of identifying the particular genes ... as possible. , In a paper published in the ...
... adult suffers a cardiorespiratory arrest the rapid application of ... death in many cases. Nevertheless, defibrillation also has its ... from the moment of the attack, the possibilities of ... to avoid avoidable deaths, more and more easy-to-handle, automatic ...
... RICHMOND, Va., Oct. 2 Filtrona Fibertec, a ... and,manufacturer of custom fluid handling components, celebrated the ... Ningbo, China with a Grand Opening,celebration. (Logo: ... an increase of more than double the size ...
... California, October 2 joimax GmbH, Campbell,CA, is pleased ... Inc. the company is moving to larger premises in ... October 1st, 2007,joimax, Inc. will be located at ... CA 95008 USA "This move reflects the strong ...
... Nutrition Systems, LLC has added over,6,000 menu items ... dining,restaurant chains to http://www.NutritionPedia.com, the only ... find out the,nutritional content of their favorite menu ... dining and buffet style restaurants such as,Applebee,s Neighborhood ...
... Cements Position as Leading ,Single Source, Provider for ... Healthcare Technology Based Mobility ... Inc. (Nasdaq:,IFLG), a leading technology provider of mobile ... today that it has acquired,Healthcare Informatics Associates, Inc. ...
Cached Medicine News:Health News:MU researchers studying model to learn why certain cancers become resistant to drugs 2Health News:Algorithms to reanimate the heart 2Health News:Algorithms to reanimate the heart 3Health News:Filtrona Fibertec Ningbo, China Plant Celebrates Expansion 2Health News:NutritionPedia Adds Nutrition Facts for Over 6,000 Menu Items From 70 Leading Fast-Casual and Family Dining Restaurant Chains 2Health News:InfoLogix Acquires Healthcare Informatics Associates Inc. (HIA); Adds Premier Healthcare Consulting Firm and Systems Integrator 2Health News:InfoLogix Acquires Healthcare Informatics Associates Inc. (HIA); Adds Premier Healthcare Consulting Firm and Systems Integrator 3Health News:InfoLogix Acquires Healthcare Informatics Associates Inc. (HIA); Adds Premier Healthcare Consulting Firm and Systems Integrator 4
(Date:8/27/2015)... India , August 27, 2015 According ... Product (Transfer, Hammock, Toilet, Seating, Universal, Standing, Bariatric ), Material (Nylon, ... - Forecast to 2020", published by MarketsandMarkets, the Medical Lifting Sling ... USD 411.5 Million in 2015, at a CAGR of 11.4 % ... 136 ma rket data T ables and ...
(Date:8/27/2015)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), the ... and patent-protected processes to develop and market advanced ... Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental sectors ... inaccuracies in the press release issued by the ... from the Patent Trial and Appeal Board ("PTAB"). ...
(Date:8/27/2015)... According to a new market ... Standalone), by Deployment Mode (Web based, On-Premise, Cloud-Based), by ... Providers), by Component - Global Trends & Forecast to ... at $501.1 Million 2014, and is projected to reach ... from 2014 to 2019. Browse 60 ...
Breaking Medicine Technology:Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4MiMedx Corrects Inaccuracies In MTF Press Release Regarding The Recent Rulings From The Patent Trial And Appeal Board 2MiMedx Corrects Inaccuracies In MTF Press Release Regarding The Recent Rulings From The Patent Trial And Appeal Board 3MiMedx Corrects Inaccuracies In MTF Press Release Regarding The Recent Rulings From The Patent Trial And Appeal Board 4Radiology Information Systems Market Worth $722.7 Million by 2019 2Radiology Information Systems Market Worth $722.7 Million by 2019 3Radiology Information Systems Market Worth $722.7 Million by 2019 4
... Pharmaceuticals, Inc. (NASDAQ: AMPE ) ("Ampio" or ... uses for previously approved drugs and new molecular entities ... of the allowance of two important U.S. patents. The ... compounds that combine elements of diketopiperazines (same class as ...
... 2011 Reportlinker.com announces that a new ... catalogue: X-ray Equipment - ... http://www.reportlinker.com/p0683626/X-ray-Equipment---Top-5-European-Markets.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging This package ... the following European countries: Germany, United Kingdom, ...
Cached Medicine Technology:Ampio Pharmaceuticals Expands Patent Portfolio of Drugs for Treating Inflammatory Diseases 2X-ray Equipment - Top 5 European Markets 2
New - Color Coded Berman Airways. A simple idea makes size identification easier for you., ,Premium upgrade without a premium price. Color Coded Berman airways are latex-free., ,Plastic. Single use...
Plastic. Economical. Single use. Non-Sterile....
... Portex® Blue Line® uncuffed endotracheal ... or Murphy styles, in standard ... Line® adult and pediatric uncuffed ... implant-tested polyvinyl chloride with a ...
... Portex® Blue Line® uncuffed endotracheal ... or Murphy styles, in standard ... Line® adult and pediatric uncuffed ... implant-tested polyvinyl chloride with a ...
Medicine Products: