Navigation Links
Nature Reviews Cancer article traces possible role of damaged DNA in tumor development
Date:3/4/2011

Atlanta - DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.

Paul Doetsch, PhD, professor of radiation oncology and biochemistry and associate director for basic research at Emory's Winship Cancer Institute and Damien Brgeon, PhD, at Institut de Gntique et Microbiologie in Paris, have outlined the role this process known as transcriptional mutagenesis might play in tumor development in a Nature Reviews Cancer article published on February 24, 2011.

"The majority of human cells do not multiply continuously but are slow-replicating and devote a large part of their energy to transcription," say the authors. "DNA damage can miscode at the damaged site and produce mutant transcripts. This process is transcriptional mutagenesis and could lead to the production of mutant proteins and may therefore be important in tumor development."

Transcriptional mutagenesis occurs when cells with damaged DNA produce bad messages during transcription, which leads to the creation of mutant proteins. Scientists already have learned that some genetic damages may block the transcription process, which is a signal for DNA repair molecules to move in and correct the mistake. When certain types of DNA damage are present, however, the non-dividing cells are capable of continuing transcription through the damage despite the erroneous coding messages. This problem can be exacerbated when cells have defects for repairing DNA damage.

As Doetsch and Brgeon note, data on this process are accumulating in several laboratories around the world, and evidence is mounting that transcriptional mutagenesis could have an important role in tumor development and other biological outcomes, including the development of drug resistance. However, at this point there is not enough evidence to know the extent to which transcriptional mutagenesis is involved in tumor development.

"One will have to follow the progeny of a single cell to determine whether cancerous growth can be initiated by the transient expression of oncogenic proteins or the disruption of signaling pathways," the authors say. "Future studies addressing these issues will provide additional insights into the mechanisms and consequences of transcriptional mutagenesis and further establish the role of this process in tumor development."


'/>"/>

Contact: Vince Dollard
vdollar@emory.edu
404-778-4580
Emory University
Source:Eurekalert  

Related medicine news :

1. Digital Signatures Presented at Electronic Document Management Conference
2. Natures Peak Products Along With Company President Paul Wilkinson Were Recently Featured on Segment of Lifetime TV Networks Nationally Broadcast Show The Balancing Act
3. Acne is Killed by Using Same Formula that Nature Uses to Keep Our Eyes Free from Bacteria
4. Nature's Aide Vitamins, Inc. Announces a New Science Driven Osteo-Guard Vitamin Formula Designed to Quickly and Safely Halt Bone Deterioration
5. Genentech uses Complete Genomics human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature
6. How to Partner With Nature ~ A Timely New Program
7. Basque researchers apply chemistry to restoration of paintings and dating of signatures
8. Molecular Signatures in Post-Mortem Brain Tissue of Younger Individuals at High Risk for Alzheimer's Disease
9. Spending time in nature makes people feel more alive, study shows
10. Signature Forum Celebrates 10th Anniversary
11. Molecular signatures may aid fight against pediatric liver disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nature Reviews Cancer article traces possible role of damaged DNA in tumor development
(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy Specialists (TexPTS) is ... in Building 2. The clinic is the group’s second in New Braunfels and 22nd ... company’s second New Braunfels location brings things full circle for the group, “It’s crazy ...
(Date:3/23/2017)... ... ... 82% of adults are unaware of the dangers that infectious bacteria play in mouth disease, ... times a day that dentists recommend. The ramifications of improper oral upkeep go far beyond ... missing 164 million hours of work each year due to dental issues. That is why ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... Oriented Disease Management Accreditation from the NCQA. The accreditation covers StayWell’s asthma, coronary ... , Accredited status is granted to organizations that have excellent programs for the ...
(Date:3/23/2017)... Fort Collins, CO (PRWEB) , ... March 23, ... ... services firm serving the families and businesses of the greater Fort Collins area, ... charity campaign in their ongoing community involvement program. Donations to this worthy cause ...
(Date:3/23/2017)... ... ... conference will prominently feature 150+ Hospital and Health System Executive Speakers including: , ... 43rd President of the United States of America: George W. Bush , ... the Ring: Sugar Ray Leonard , JD, Chairperson, McGuireWoods LLP: Amber McGraw Walsh ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017 As a result ... with the prevalence of allergic diseases, cutting edge ... currently revolutionising the ways in which pharmaceutical and ... 2017 promises to be both a high quality ... allergy interest groups, immunologists, research scholars and doctors. ...
(Date:3/23/2017)... Summary Global ... guide Primary Hyperoxaluria - Pipeline Review, H1 2017, ... Urinary System And Sex Hormones) pipeline landscape. ... recurrent kidney and bladder stones. It results from ... include blood in the urine, pain when urinating, ...
(Date:3/23/2017)... and VANCOUVER, British Columbia , ... SPHS ) (the "Company" or "Sophiris"), a clinical ... of urological diseases, today announced that data from its ... drug as a focal treatment for localized prostate cancer, ... 2017 at the 32 nd Annual European Association ...
Breaking Medicine Technology: