Navigation Links
Naturally produced estrogen may protect women from Parkinson's disease
Date:2/25/2009

February 25, 2009 (Bronx, NY) Women who have more years of fertility (the time from first menstruation to menopause) have a lower risk of developing Parkinsons disease than women with fewer years, according to a large, new study by researchers at Albert Einstein College of Medicine of Yeshiva University.

These findings, involving nearly 74,000 women, suggest that longer exposure to the bodys own, or endogenous, hormones, including estrogen, may help protect the brain cells that are affected by Parkinsons disease, says lead author Rachel Saunders-Pullman, M.D., M.P.H., M.S., assistant professor of neurology at Einstein and attending physician in neurology at Beth Israel Medical Center, an affiliate of Einsteins in Manhattan.

An abstract of the study was released today by the American Academy of Neurology (AAN). Further study details will be presented at AANs 61st Annual Meeting in Seattle, April 25 - May 2, 2009.

After Alzheimers disease, Parkinsons disease is the most common neurodegenerative disease. About 1.5 million Americans currently have Parkinsons, characterized by symptoms that can include tremor (shaking), slowness of movement, rigidity (stiffness), and difficulty with balance. The condition typically develops after the age of 60, although 15 percent of those diagnosed are under 50. There is no cure for Parkinsons, although medications or surgery can ease symptoms of the disease.

Parkinsons disease is almost twice as common in men as in women, and researchers have long hypothesized that sex hormones might play a role in the disease.

In the current study, researchers analyzed the records of the Womens Health Initiative (WHI) Observational Study and focused on those women who developed Parkinsons disease. The study involved about 73,973 women who underwent natural menopause.

The study found that women who had a fertile lifespan of more than 39 years had about a 25 percent lower risk of developing Parkinsons compared with women who had a fertile lifespan shorter than 33 years.

In addition, the data showed that women who had four or more pregnancies were about 20 percent more likely to develop Parkinsons disease than were women who had three or fewer pregnancies. One explanation for this finding is that the post-partum period, which is typically one with lower levels of estrogen, subtracts from a womans total fertile lifespan, says co-author Sylvia Wassertheil-Smoller, Ph.D., professor of epidemiology and population health and the principal investigator of the WHI study at Einstein.

Overall, our findings might lead one to assume that hormone therapy would make sense as a neuroprotective agent, says Dr. Saunders-Pullman. However, we also found that women who were taking hormone therapy did not have a lower risk for Parkinsons. Thus, our data does not support a role for treatment with exogenous hormones, that is, hormones that originate outside the body, to prevent Parkinsons.

In fact, hormone therapy can have harmful neurological effects. Earlier studies in the Womens Health Initiative demonstrated that hormone therapy increases ones risk for both stroke and dementia, says Dr. Wassertheil-Smoller. Clearly, we need to conduct more research into estrogens effects on the brain.


'/>"/>

Contact: Deirdre Branley
sciencenews@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. HPS Establishes Independent Website for its Patent-Pending Mood-Enhancing Compound Naturally Found in Sea Coral
2. HPS Files Comprehensive Patent Outside the Unites States for Mood-Enhancing Compound Naturally Found in Sea Coral
3. HPS Files Patent for Mood-Enhancing Compound Naturally Found in Sea Coral
4. Top Tips To Naturally Heal Dry Skin And Moisturize This Winter
5. Naturally Safe Cold Remedy Challenges Effectiveness of Over-The-Counter Cold Medications
6. Hain Celestial to Present at Canaccord Adams Healthy Living Naturally Boston Conference on October 15, 2008
7. New Skin Revitalizing Product Uses Naturally Occurring Serum for the Repair of Sun Damaged Skin
8. Children are naturally prone to be empathic and moral
9. World Renowned Hand Surgeon Helps Patients Conquer Joint Discomfort Naturally
10. Study shows pine bark naturally reduces cardiovascular risk factors in diabetics
11. Study Shows Pine Bark Naturally Reduces Cardiovascular Risk Factors in Diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... New studies ... of injured workers across 15 states. The outcomes examined in these studies include ... medical care, and satisfaction with medical care. , “The goal of the studies ...
(Date:5/25/2016)... ... 25, 2016 , ... Today Omega Institute, a leading destination for yoga education ... training opportunities in the growing field of yoga therapy . Yoga therapy ... with specific health issues—including injuries, illnesses, and temporary or chronic health conditions. , “Yoga ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... planning services and products in the developing world, is pleased to release their ... prevent over 5 million unwanted pregnancies, almost 14,000 maternal deaths and 3.8 million ...
(Date:5/25/2016)... Coral Gables, FL (PRWEB) , ... May 25, ... ... in its Cross Benefit Clearinghouse supporting the real time adjudication of medical service ... Urgent Care providers using their current medical claims management software. The TransactRx Cross ...
(Date:5/25/2016)... ... May 25, 2016 , ... The University of San Francisco ... Professions. She will lead a team of more than 100 full-time faculty and staff, ... role as dean in late August. , Baker comes to USF from the University ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 Inivata, a global ... circulating tumour DNA (ctDNA) analysis to improve personalised ... Professor Clive Morris as Chief Medical ... clinical development programme, scientific collaborations, and through to ... improvements in clinical outcomes for patients. ...
(Date:5/24/2016)... , May 24, 2016 ... médica para ayudar a los médicos a compartir sus ... pacientes a escala mundial. Profesionales médicos de Europa, África, ... se han apuntado a la aplicación, que combina la ... un entorno totalmente seguro. Educación   ...
(Date:5/24/2016)... 24, 2016  Diana Russell suffers from a form ... the inside out.  This disease has put her in ... children and grandchildren to leave her home.  Because of ... cannot haul the wheelchair.  So if there is a ... Diana is left to wait for the bus. ...
Breaking Medicine Technology: