Navigation Links
Naturally produced estrogen may protect women from Parkinson's disease
Date:2/25/2009

February 25, 2009 (Bronx, NY) Women who have more years of fertility (the time from first menstruation to menopause) have a lower risk of developing Parkinsons disease than women with fewer years, according to a large, new study by researchers at Albert Einstein College of Medicine of Yeshiva University.

These findings, involving nearly 74,000 women, suggest that longer exposure to the bodys own, or endogenous, hormones, including estrogen, may help protect the brain cells that are affected by Parkinsons disease, says lead author Rachel Saunders-Pullman, M.D., M.P.H., M.S., assistant professor of neurology at Einstein and attending physician in neurology at Beth Israel Medical Center, an affiliate of Einsteins in Manhattan.

An abstract of the study was released today by the American Academy of Neurology (AAN). Further study details will be presented at AANs 61st Annual Meeting in Seattle, April 25 - May 2, 2009.

After Alzheimers disease, Parkinsons disease is the most common neurodegenerative disease. About 1.5 million Americans currently have Parkinsons, characterized by symptoms that can include tremor (shaking), slowness of movement, rigidity (stiffness), and difficulty with balance. The condition typically develops after the age of 60, although 15 percent of those diagnosed are under 50. There is no cure for Parkinsons, although medications or surgery can ease symptoms of the disease.

Parkinsons disease is almost twice as common in men as in women, and researchers have long hypothesized that sex hormones might play a role in the disease.

In the current study, researchers analyzed the records of the Womens Health Initiative (WHI) Observational Study and focused on those women who developed Parkinsons disease. The study involved about 73,973 women who underwent natural menopause.

The study found that women who had a fertile lifespan of more than 39 years had about a 25 percent lower risk of developing Parkinsons compared with women who had a fertile lifespan shorter than 33 years.

In addition, the data showed that women who had four or more pregnancies were about 20 percent more likely to develop Parkinsons disease than were women who had three or fewer pregnancies. One explanation for this finding is that the post-partum period, which is typically one with lower levels of estrogen, subtracts from a womans total fertile lifespan, says co-author Sylvia Wassertheil-Smoller, Ph.D., professor of epidemiology and population health and the principal investigator of the WHI study at Einstein.

Overall, our findings might lead one to assume that hormone therapy would make sense as a neuroprotective agent, says Dr. Saunders-Pullman. However, we also found that women who were taking hormone therapy did not have a lower risk for Parkinsons. Thus, our data does not support a role for treatment with exogenous hormones, that is, hormones that originate outside the body, to prevent Parkinsons.

In fact, hormone therapy can have harmful neurological effects. Earlier studies in the Womens Health Initiative demonstrated that hormone therapy increases ones risk for both stroke and dementia, says Dr. Wassertheil-Smoller. Clearly, we need to conduct more research into estrogens effects on the brain.


'/>"/>

Contact: Deirdre Branley
sciencenews@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. HPS Establishes Independent Website for its Patent-Pending Mood-Enhancing Compound Naturally Found in Sea Coral
2. HPS Files Comprehensive Patent Outside the Unites States for Mood-Enhancing Compound Naturally Found in Sea Coral
3. HPS Files Patent for Mood-Enhancing Compound Naturally Found in Sea Coral
4. Top Tips To Naturally Heal Dry Skin And Moisturize This Winter
5. Naturally Safe Cold Remedy Challenges Effectiveness of Over-The-Counter Cold Medications
6. Hain Celestial to Present at Canaccord Adams Healthy Living Naturally Boston Conference on October 15, 2008
7. New Skin Revitalizing Product Uses Naturally Occurring Serum for the Repair of Sun Damaged Skin
8. Children are naturally prone to be empathic and moral
9. World Renowned Hand Surgeon Helps Patients Conquer Joint Discomfort Naturally
10. Study shows pine bark naturally reduces cardiovascular risk factors in diabetics
11. Study Shows Pine Bark Naturally Reduces Cardiovascular Risk Factors in Diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... EXTON, Pa. , Oct. 10, 2017   ... leader in innovative solutions for injectable drug administration, today ... of West,s ID Adapter for improving the intradermal administration ... the Fourth Skin Vaccination Summit in May 2017 by ... Team Lead, Polio Department, World Health Organization (WHO), and ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
(Date:10/4/2017)...  According to the Centers for Disease Control and Prevention (CDC), ... Urgent Care is helping communities across Massachusetts , ... offering no-cost* flu shots through the end of the month. ... regulations. ... a flu shot is by the end of October, according to the ...
Breaking Medicine Technology: