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Naturally occurring brain signaling chemical may be useful in understanding Parkinson's
Date:2/11/2011

n microglial-induced inflammation," said USF doctoral student Mibel Pabon, a study co-author.

"This suggests that the communication between neurons and glial cells may play a role in Parkinson's disease neurodegeneration," said Carmelina Gemma, PhD, co-lead scientist for the study, assistant professor in USF's Department of Neurosurgery and Brain Repair, and a research biologist at the James A. Haley Veterans' Hospital. "We found that even small increases in CX3CL1 can be neuroprotective by suppressing microglia activation and, therefore, reducing inflammation."

The researchers concluded that the CX3CR1/CX3CL1 "axis" may be an important target for drug discovery efforts aimed at modulating microglia activation associated with Parkinson's disease."


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Contact: Randolph Fillmore
rfillmor@health.usf.edu
813-974-0868
University of South Florida (USF Health)
Source:Eurekalert

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