Navigation Links
Naturally occurring brain signaling chemical may be useful in understanding Parkinson's

Targeting the neuroinflammatory causes of Parkinson's disease with a naturally present brain chemical signal could offer a better understanding of the clinical mechanisms of the disease and open a future therapeutic window, reports a team of researchers from the University of South Florida Department Neurosurgery and Brain Repair and the James A. Haley Veterans' Administration Hospital, Tampa.

Their findings are published online in the Journal of Neuroinflammation (http://www.jneuroinflammation).

Brain inflammation has been clearly shown in PD, and the brain's microglia - small cells that regulate the chemical environment of neural cells - play a role in the inflammatory process and disease progression, said study lead author Paula C. Bickford, PhD, professor of neurosurgery at USF and a senior research career scientist at the Haley VA Hospital.

"In the brain, one aspect of immune regulation occurs through neurons," said Dr. Bickford. "Immune cells called microglia can damage neurons by producing bioactive molecules. On the other hand, a neuron-generated signaling chemical, or fractalkine, also called CX3CL1, suppresses the activation of microglia. Our study examined whether adding CX3CL1 beyond normal levels could decrease microglial activation and, therefore, play a neuroprotective role by helping prevent the loss of important neural cells in an animal model of Parkinson's disease."

Using rat models of Parkinson's with known inflammatory components, the researchers added CX3CL1 in varying doses and found that, in all cases, CX3CL1 (which has a single receptor CX3CR1 found on microglia) reduced the loss of dopamine cells. The loss of dopamine rich nerve fibers in the brain is a key aspect of Parkinson's, leading to movement-related symptoms such as tremors, muscle stiffness, balance problems and slowness.

"This was likely mediated by the accompanying change in microglial-induced inflammation," said USF doctoral student Mibel Pabon, a study co-author.

"This suggests that the communication between neurons and glial cells may play a role in Parkinson's disease neurodegeneration," said Carmelina Gemma, PhD, co-lead scientist for the study, assistant professor in USF's Department of Neurosurgery and Brain Repair, and a research biologist at the James A. Haley Veterans' Hospital. "We found that even small increases in CX3CL1 can be neuroprotective by suppressing microglia activation and, therefore, reducing inflammation."

The researchers concluded that the CX3CR1/CX3CL1 "axis" may be an important target for drug discovery efforts aimed at modulating microglia activation associated with Parkinson's disease."


Contact: Randolph Fillmore
University of South Florida (USF Health)

Related medicine news :

1. Naturally High Hemoglobin Levels May Not Threaten Kidney Patients
2. Upcoming Simulcast to Teach Women How to Lose Weight and Naturally Balance Hormones with Polycystic Ovarian Syndrome
3. Women with Polycystic Ovarian Syndrome and Insulin Resistance can Lose Weight and Balance Hormones Naturally with Katie Humphrey's New E-book
4. Females May Be Naturally More Prone to Stress: Animal Study
5. 'Get Pregnant' Aims To Help Couples Conceive Naturally, Faster
6. Oram Plus Set to Take the Pain out of Gum Disease and Cavities, Naturally
7. Chinks in the brain circuitry make some more vulnerable to anxiety
8. JPEG for the mind: How the brain compresses visual information
9. What makes fructose fattening? OHSU researchers find some answers in the brain
10. Gestures May Help the Brain See
11. Study Links Brain Molecule to Risk of Major Depression
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... ... announce the speakers for “Value-Based Payer-Provider Partnerships: Three Case Studies,” an upcoming ... value-based care arrangements: Essentia Health and UCare, MissionPoint Health Partners, and Intel ...
(Date:11/30/2015)... EMIGSVILLE, PA (PRWEB) , ... November 30, 2015 ... ... (CCMS) software provider, has verified that their Vasont Universal Integrator (VUI) extension unites ... handle creating, editing, and managing content as a continuous process with the latest ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... is one of a select few plastic surgeons in the New York City ... , SculpSure™ is the world’s first heat-induced laser treatment for fat loss in ...
(Date:11/30/2015)... ... November 30, 2015 , ... TransPack Volume 6 features 30 customizable transitions created ... web-styled transitions to wipes with blur & drop shadow options. Utilize the controls ... from one clip to the next with TransPack's easily customizable styles. , ...
(Date:11/30/2015)... , ... November 30, 2015 ... ... Inc. are pleased to announce their strategic partnership at the Radiological Society ... Transcription Service, Inc., and Winscribe, global providers of cutting-edge dictation and speech-enabled ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Calif. , Nov. 30, 2015 /PRNewswire/ ... the norm in U.S. medical imaging is ... increasingly popular accountable care payer-provider contracts are ... and, in their wake, alter provider-vendor relationships. ... payments will push forward new purchasing frameworks ...
(Date:11/30/2015)... JERUSALEM , Nov. 30, 2015 Oramed ... company focused on the development of oral drug delivery ... investment agreements valued at up to $50,000,000 with Hefei Tianhui Incubator of ... Oramed,s oral insulin capsule, ORMD-0801, in China ... Macau . The agreements were signed ...
(Date:11/30/2015)... N.H. , Nov. 30, 2015 ... that it will feature its latest solutions for ... early identification of cancer at the Radiological Society ... Chicago from November 29 ... recent product advances including iReveal®, an automated breast ...
Breaking Medicine Technology: