Navigation Links
Naturally-occuring protein may be effective in limiting heart attack injury and restoring function
Date:5/6/2008

Medical College of Wisconsin researchers in Milwaukee have shown for the first time that thrombopoietin (TPO), a naturally occurring protein being developed as a pharmaceutical to increase platelet count in cancer patients during chemotherapy, can also protect the heart against injury during a heart attack.

The study, led by John E. Baker PhD, professor of pediatric surgery in the division of cardiothoracic surgery, was published in the January 2008 issue of Cardiovascular Research. The importance of these findings was underscored in an accompanying editorial.

Currently there are no therapies available to directly protect the heart against the damaging effects of a heart attack. Dr. Bakers team has shown that administering a single dose of TPO to rats during a heart attack decreased the extent of permanent muscle damage to the heart and increased the ability of the heart to function afterwards, when compared with no drug treatment. Additionally, they found that a single cardioprotective treatment with TPO did not increase platelet count. This novel finding suggests the cardioprotective actions of TPO are separate from its ability to increase platelet count.

Dr. Baker has submitted a US and worldwide patent application on the tissue protective properties of TPO. Dr. Bakers discovery is licensed to Cardiopoietis, a Wisconsin LLC, formed to develop drugs for the treatment of heart attacks.

TPO is a hormone which is naturally produced by the liver and kidney. Dr. Bakers investigative team had previously shown that erythropoietin, a protein and pharmaceutical currently in clinical use to treat anemia in end-stage kidney disease, protects the rat heart against injury during a heart attack. They found that although erythropoietin and TPO have separate functional roles, there were similarities in the structures of the two proteins that suggested TPO may have protective properties similar to erythropoietin.


'/>"/>

Contact: Toranj Marphetia
toranj@mcw.edu
414-456-4744
Medical College of Wisconsin
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... ... ... Law Group is pleased to announce the relocation of the firm's headquarters to 225 ... a state of the art building, located with easy access to New York City's ... "We are pleased to service our clients from such a premier location and we ...
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... SC&H Group, ... Service, which aims to give back to the community through company-wide volunteering efforts. , ... SC&H Group dedicate the day to assisting those in need throughout Baltimore and Washington ...
(Date:7/7/2015)... ... , ... At the end of June Pacific Prime Renewals team in Hong Kong announced ... by the Renewals Manager, Danielle Cotton, aims to not only reduce but eventually eliminate the ... explained, “We send anything between 300 and 600 pieces of paper per month. Not to ...
(Date:7/7/2015)... ... 07, 2015 , ... Summer is a great time to get outside and ... sharing some safety tips. , Jean Tapley, senior wellness coordinator at Amica, suggests the ... , Start slowly. Going from no activity to several hours of activity ...
(Date:7/7/2015)... ... ... Healthpointe is proud to announce the addition of Dr. Pedro S. Alupay to ... evaluating and treating patients with orthopedic complaints, such as lumbar back pain or cervical ... Biology from the University of the East, Manila, Dr. Alupay earned his Doctorate of ...
Breaking Medicine News(10 mins):Health News:SC&H Group Celebrates 9th Annual Day of Service 2Health News:Pacific Prime Hong Kong Renewals Team Starts Push to go Green 2Health News:Amica Insurance Has 7 Summer Safety Tips 2Health News:Dr. Pedro S. Alupay, M.D., Now Providing Pain Management Services at Healthpointe in Irwindale 2Health News:Dr. Pedro S. Alupay, M.D., Now Providing Pain Management Services at Healthpointe in Irwindale 3
... ... obscure Georgia Law that forces insurance companies to cover Sedation Dentistry for Georgia Dental Patients ... over 20 years and he just found out about the law so the general public ... ...
... SIAL ) today announced that it has entered into an agreement with Pfizer under which Sigma-Aldrich will sell approximately 100 Pfizer-developed small molecule ... ... , , ... ...
... ... a company that builds open source platforms and develops advanced research ... Health (NIH) totaling more than $600,000 to focus research efforts on ... the research is to work towards an interactive simulator that replicates ...
... The presence of plaque on an abdominal CT scan is ... to a Henry Ford Hospital study. Researchers found that ... artery disease when the CT scan showed very high levels ... of the abdominal aortic calcium also increased their risk of ...
... Diovan, Starlix also had limited or no effect in ... March 14 (HealthDay News) -- Hopes that two available ... causes in overweight people with poor sugar metabolism have ... trial involved two drugs prescribed for other reasons -- ...
... ... named to the editorial board of Otology/Neurotology. , ... (Vocus) March 13, 2010 -- Jed ... editorial board of Otology/Neurotology. The official journal of the American Otological Society and ...
Cached Medicine News:Health News:Georgia Dentist Uncovers Obscure Law That Helps Dental Patients With Severe Anxiety 2Health News:Sigma-Aldrich Reaches Agreement to Sell Pfizer's Bioactive Small Molecule Compounds 2Health News:Sigma-Aldrich Reaches Agreement to Sell Pfizer's Bioactive Small Molecule Compounds 3Health News:Sigma-Aldrich Reaches Agreement to Sell Pfizer's Bioactive Small Molecule Compounds 4Health News:Sigma-Aldrich Reaches Agreement to Sell Pfizer's Bioactive Small Molecule Compounds 5Health News:National Institutes of Health Awards Kitware Over $600,000 to Develop Advancements in Neurosurgical Simulation 2Health News:National Institutes of Health Awards Kitware Over $600,000 to Develop Advancements in Neurosurgical Simulation 3Health News:Plaque on CT scan is strong predictor of heart disease, worse long-term outcomes 2Health News:2 Drugs Fail to Prevent Diabetes in the Overweight 2Health News:2 Drugs Fail to Prevent Diabetes in the Overweight 3Health News:Summit Medical Group Physician Named to Medical Journal Editorial Board 2Health News:Summit Medical Group Physician Named to Medical Journal Editorial Board 3
(Date:7/7/2015)... SAN FRANCISCO , July 7, 2015 ... to reach USD 1,197.7 million by 2020, growing at an ... a new study by Grand View Research, Inc. Introduction of ... rates coupled with growing awareness levels pertaining to the advantages ... over the next six years. In addition, presence of untapped ...
(Date:7/7/2015)... 2015 /PRNewswire/ -- Mindray Medical International Limited ("Mindray", NYSE: ... marketer of medical devices worldwide, announced today a ... Wuhan Dragonbio Surgical Implant Co., Ltd. ("Dragonbio") for ... a domestic medical orthopedic-product provider that specializes in ... to today,s announcement, Mindray already has a controlling ...
(Date:7/7/2015)... , July 7, 2015 EnteroMedics Inc. ... devices that use neuroblocking technology to treat obesity, metabolic ... its previously announced public offering of 32,000,000 units. Each unit ... Series A warrant to purchase one share of common ... Investors whose purchase of units in the offering would ...
Breaking Medicine Technology:Breast Pumps Market To Reach $1,197.7 Million By 2020: Grand View Research, Inc. 2Breast Pumps Market To Reach $1,197.7 Million By 2020: Grand View Research, Inc. 3Breast Pumps Market To Reach $1,197.7 Million By 2020: Grand View Research, Inc. 4Mindray Medical to Acquire the Remaining Stake in Wuhan Dragonbio 2Mindray Medical to Acquire the Remaining Stake in Wuhan Dragonbio 3Mindray Medical to Acquire the Remaining Stake in Wuhan Dragonbio 4EnteroMedics Inc. Announces Pricing of $16.0 Million Public Offering of Common Stock and Warrants 2EnteroMedics Inc. Announces Pricing of $16.0 Million Public Offering of Common Stock and Warrants 3
... REDBANK, New Jersey and MELBOURNE, Australia, November 4, 2011 ... safety solutions lands CE Mark for GAMMEX® Powder-Free Gloves ... its introduction in Australia, Ansell today announced it is ... GAMMEX® Powder-Free glove with AMT Antimicrobial Technology. ...
... PALM BEACH, Fla., Nov. 4, 2011 China Nuvo ... Inc. has signed an agreement with Bluewater Surgical, Inc. ... SurgLine products for spine surgery, sports medicine, trauma surgery ... surgery centers as an alternative to the high priced ...
Cached Medicine Technology:Ansell Extends Success of AMT Antimicrobial Technology for Surgical Gloves With Introduction in Europe 2China Nuvo Solar Energy, Inc. Announces Third-Party Distribution Agreement With Bluewater Surgical, Inc. 2China Nuvo Solar Energy, Inc. Announces Third-Party Distribution Agreement With Bluewater Surgical, Inc. 3
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
Medicine Products: