Navigation Links
Natural secretion marks difference between mole and melanoma
Date:2/7/2008

s, the researchers conducted a genome-wide screen of cells made to express the BRAF mutation (known as BRAFV600E) found in both melanoma and moles. They then disabled other genes in search of those that would allow the cells to begin dividing as they would in cancer.

The screen turned up 17 genes including many of the "usual suspects"genes already known to play a role in the cell cycle and cell death pathways, Green said. But the presence of the secreted protein IGFBP7 among those factors came as a complete surprise.

Expression of BRAFV600E in cells leads to the synthesis and secretion of IGFBP7, they report, which acts on that cell and its neighbors to inhibit the BRAF-driven signal and induce cell senescence and death.

Moreover, they found that IGFBP7 delivered to human melanoma cells could slow their growth. That finding raised the possibility that the protein might fight BRAF mutant tumors as well.

They injected mice with human melanoma cells both with and without the activated BRAF mutation. The mice were then injected at the tumor site with IGFBP7 or a control chemical. The protein substantially suppressed the growth of tumors, they show, but only those with the abnormal form of BRAF.

Lastly, they report that normal skin melanocytes express low but detectable levels of IGFBP7. In contrast, nevi carrying the BRAF mutation express high levels of IGFBP7, consistent with the finding that the mutant BRAF in melanocytes increases the protein's levels. Significantly, they found, expression of IGFBP7 was not detectable in BRAFV600E positive melanomas.

Based on their findings, the researchers proposed that loss of IGFBP7 expression allows escape from BRAFV600E-mediated senescence and is a critical step in the genesis of melanoma.

"Activated BRAF-positive metastatic melanoma is an aggressive disease that is refractory to conventional chemotherapeutic agents and lacks adequate treatment options," the researc
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists Develop Natural Protection for Stored Foods
2. Preparation for Natural Disasters Critical for People With Diabetes, Chronic Medical Conditions
3. SIV infection of natural hosts provides new insights into HIV disease complexity
4. Big Relief for Tiny Itch Mites Found in All Natural Spray Remedy
5. Natural aorta grafts have few side effects for infection-prone patients
6. Fitness Champion Natalie Waples to be Spokesperson for Natural Nutrition International Direct Marketing Campaign
7. New Herbal Water Creating Taste Sensation: Ayalas Herbal Water Has No Calories, No Preservatives and No Artificial Additives. Just All the Natural Benefits of Herbs!
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. The Village Company Unveils Natural Bath and Body Solutions for Everyday Ailments
10. All-Natural Organic Yerba Mate and Organic Aloe Vera Exfoliating Soaps will Help Save Your Skin(TM)
11. New Nutraceutical That Stabilizes Blood Sugar Naturally is Introduced
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014 The American Diabetes Association ... diabetics curb their sweet tooth, but the most recent ... September, suggests that zero-calorie sweeteners may actually be linked ... , The Weizmann Institute of Science in Israel ... to mice, the mice developed glucose intolerance. They then ...
(Date:9/30/2014)... Regenerative Medicine Solutions (RMS) is set ... Nashville, Tennessee. RMS welcomes the launch of an entirely ... of a new treatment center for the Lung Institute. ... Institute to Nashville, the hope is to bring awareness ... diagnosed and undiagnosed. With Nashville being a hub for ...
(Date:9/30/2014)... Sept. 30, 2014 (HealthDay News) -- Medicare should cover ... high risk for the disease, a coalition of more ... coalition, which includes the Lung Cancer Alliance, the Society ... American Cancer Society and the American Society of Clinical ... to the U.S. Centers for Medicare & Medicaid Services ...
(Date:9/30/2014)... Healthcare advocates, patient navigators, healthcare providers and caregivers ... Consultants (#NAHAC) fifth annual conference, “Mastering the Power and ... 30th - Nov. 1st, 2014 in Chicago, Illinois. ... Practices for the Field of Healthcare Advocacy. As ... a set of standards and best practices. NAHAC stepped ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 To mark ... Editorial Board of Living with a Disability magazine ... light on hematological disorders as disabling conditions. ... more than a diagnosis to establish a disability related ... thrombocytomenia, myelofibrosis, hereditary telangiectasia, coagulation defects, polycythemia vera, and ...
Breaking Medicine News(10 mins):Health News:Artificial Sweeteners May be Linked to Greater Diabetes Risk 2Health News:Regenerative Medicine Solutions Expanding 2Health News:Groups Call for Medicare Coverage of Lung Cancer Screening 2Health News:Living with a Disability Magazine Marks National Sickle Cell Health Month with New Article on Hematological Disorders 2Health News:Living with a Disability Magazine Marks National Sickle Cell Health Month with New Article on Hematological Disorders 3
... NAPA, Calif., Feb. 6 Senetek PLC (OTC,Bulletin ... the development,of technologies that target the science of ... new website; http://www.senetekplc.com ., Mr. Frank ... are pleased to bring greater visibility to Senetek ...
... to come, WASHINGTON, Feb. 6 Across five ... people and supplies,are flowing in to provide care to ... 5. In every tornado-affected,community, Red Cross workers are on ... rescue workers, and lending emotional support to,all., More ...
... are both highly effective in treating mild to moderately severe ... Medicine have found the first study to compare the ... skin disorder. , Peels using beta-hydroxy acid (or BHA) had ... longer than did peels using alpha-hydroxy acid (or AHA), the ...
... clinical trial involving the use of gene therapy in combination ... more effective than radiation therapy alone for patients with intermediate ... a $9 million grant from the National Cancer Institute (NCI) ... therapy to treat prostate cancer. , As part ...
... seek restatement of Beth Israel Deaconess,Medical Center audit, ... T. Linde should apply the same Sarbanes-Oxley,standards used by ... on the board of Beth Israel Deaconess Medical Center ... East. Linde is,also the president and CFO of Boston ...
... saving treatment option for people with end-stage liver disease. ... supply. Each year only about one-third of people who ... patients die while waiting. In the February issue of ... for allocating donor organs in the United States affects ...
Cached Medicine News:Health News:Senetek PLC Announces Launch of New Website 2Health News:Massive American Red Cross Tornado Relief Effort Spans Five States 2Health News:Treating acne: 2 different acid peels are both effective, study finds 2Health News:Henry Ford Hospital expands research on gene and radiation therapy for prostate cancer 2Health News:Henry Ford Hospital expands research on gene and radiation therapy for prostate cancer 3Health News:Boston Properties Executive and Board Member Should Use Sarbanes-Oxley Disclosure Rules in Non-Profit Role, Asserts 1199 SEIU 2Health News: Mayo Clinic Proceedings contributors discuss impact of donor organ allocation system 2Health News: Mayo Clinic Proceedings contributors discuss impact of donor organ allocation system 3
(Date:9/30/2014)... WASHINGTON , Sept. 30, 2014  The ... nurse managers to call them at 866-714-6466 if ... admitting Medicare patients, who should have been sent ... The reward potential can be substantial, as the ... Photo - http://photos.prnewswire.com/prnh/20140929/149016 ...
(Date:9/30/2014)... Summary This report presents the ... regarding their Information & Communications Technology (ICT) investment ... allocate their ICT budgets across the core areas ... communications, and consulting. Key Findings ... that X% of respondents anticipate an increase in ...
(Date:9/30/2014)... 2014  eHealth, electronic access of medical records, ... this information, has become a major industry. According ... not translated into user-friendly, effective products. ... http://photos.prnewswire.com/prnh/20140929/149123 For this reason, ... MWD® Health Manager iEHR, a multilingual web-based application ...
Breaking Medicine Technology:Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 2Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 3Corporate Whistleblower Center Urges ER Doctors or Nurse Managers to Call Them if They Have Proof of a Hospital Needlessly Admitting Medicare Patients Instead of Sending Them Home 4ICT investment trends in pharmaceuticals - Enterprise ICT spending patterns through to the end of 2015 2ICT investment trends in pharmaceuticals - Enterprise ICT spending patterns through to the end of 2015 3MWD Challenges the Big eHealth Players With New Software for Your Smartphone 2
... Council on Exercise (ACE), America,s leading authority on fitness ... organization in the world, today announced the launch of ... in America.  As an extension of the organization,s vision ... engage in physical activity and inspire them to make ...
... Hologic, Inc. (Hologic or the Company) (Nasdaq: ... premium diagnostics products, medical imaging systems and surgical products dedicated ... products that are the future of women,s imaging at the ... McCormick Place in Chicago, November 28 through December 2, 2010. ...
Cached Medicine Technology:American Council on Exercise (ACE) Announces Nationwide Effort to Eliminate Obesity in America 2American Council on Exercise (ACE) Announces Nationwide Effort to Eliminate Obesity in America 3Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 2Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 3Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 4Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 5Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 6Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 7Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 8Hologic Encourages Health Professionals to Get the Facts About Women's Imaging at RSNA 2010 9
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: