Navigation Links
Natural method for clearing cellular debris provides new targets for lupus treatment
Date:2/24/2012

Augusta, Ga. Cells that die naturally generate a lot of internal debris that can trigger the immune system to attack the body, leading to diseases such as lupus.

Now Georgia Health Sciences University researchers report that an enzyme known to help keep a woman's immune system from attacking a fetus also helps block development of these autoimmune diseases that target healthy tissues, such as DNA or joints.

The findings point toward new treatment strategies for autoimmune diseases, which are on the rise in light of a germ-conscious society that regularly destroys many of the previously pervasive microbes that made the immune system more tolerant.

"The basic premise of lupus is you have lost normal tolerance to yourself, your own proteins and DNA," said Dr. Tracy L. McGaha, GHSU immunologist and corresponding author of the study published in Proceedings of the National Academy of Sciences.

They found that IDO, or indoleomine 2,3-dioxegenase, helps promote tolerance to debris generated by natural cell death and that when IDO is removed from the mix, the debris spurs an immune response that can trigger autoimmune disease. In mice genetically programmed to develop lupus, blocking IDO resulted in earlier, more aggressive disease.

"This connects IDO and macrophages. It's a newly described role for IDO in regulation of tolerance toward self," McGaha said. Consequently, increasing IDO production or its downstream effects might be a way to regain lost tolerance, he said.

They studied activity in the spleen, a hard-working immune organ, that constantly filters blood. In a perfectly orchestrated defense, the entrance to the spleen is surrounded by immune cells that scour blood for viruses, bacteria, even fat and cholesterol floating by.

A nearby subset of macrophages, which are essentially scavengers, then capture and consume the undesirables, McGaha said. Interestingly, a lot of what m
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Natural enzyme provides potential new approach for treating graft-vs.-host disease
2. A natural dye obtained from lichens may combat Alzheimers disease
3. Natural killer cells could be key to anthrax defense
4. New scarless surgery takes out tumors through natural skull opening
5. BU presents approach to access biorelevant structures by remodeling natural products
6. Natural processes can limit spread of arsenic in water, says study
7. Soy-based natural S-equol supplements improve crows feet skin wrinkles in menopausal women
8. For Kids, Natural Disasters Can Whip Up Worries
9. Bodys natural marijuana-like chemicals make fatty foods hard to resist
10. Study shows pine bark naturally improves heart function
11. Cooling system may build eggs natural defenses against salmonella
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... ... Renowned review site BestMillionaireDatingSites.com recently refreshed its list of the top dating platforms for ... dating service in the segment. , A representative from the site said, “You certainly ... the right dating platform so that they can make the most of it and ...
(Date:8/4/2015)... ... ... Statement by Paul Gionfriddo, President and CEO, Mental Health America , " ... of 2015 by Senators Bill Cassidy and Christopher Murphy. It is another ... “This legislation and H.R. 2646 [The Helping Families in Mental Health Crisis ...
(Date:8/4/2015)... ... August 04, 2015 , ... ... the American Association of Tissue Banks (AATB) as an Affiliate Member. Exsurco ... honor donors, and to save and improve lives by promoting the safety, quality ...
(Date:8/4/2015)... ... August 04, 2015 , ... Rhode Island Medical Imaging (RIMI) is pleased ... Medical Building on Wake Robin Road in Lincoln, RI. This satellite office will ... the most extensive out-patient x-ray hours in the state, which includes evenings and weekends. ...
(Date:8/4/2015)... ... August 04, 2015 , ... Ryadon ... customers. Finding reliable hardware can be difficult and troublesome for companies. ... office together or designing a new facility, it is imperative to include only ...
Breaking Medicine News(10 mins):Health News:BestMillionaireDatingSites.com Publishes Reviews of the Best Dating Sites for Wealthy Singles 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 3Health News:Exsurco Medical Joins AATB as Affiliate Member 2Health News:Rhode Island Medical Imaging Opens Satellite Imaging Center on Wake Robin Road in Lincoln 2Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 2Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 3Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 4
... medical researchers in the United States has discovered what may ... cancer.// ,The scientists from the University of ... halting the activity of a single enzyme called aldose reductase. ... of biochemical signals that promotes inflammation and colon cancer cell ...
... of interest for post menopausal women with breast cancer ... Herceptin (trastuzumab) from Roche// and Arimidex (anastrozole) from AstraZeneca ... time by 4.8 months. ,A Phase III clinical ... the progression by just 2.4 months after which the ...
... people affected by chikungunya, a viral fever caused by mosquitoes//, ... the state government on the nature of the disease. ... not chikungunya. The government is doing its best to contain ... have asked people from other systems of medicines like Ayurveda ...
... an undiagnosed disorder and fighting to stay in Canada, has ... state after three years.// ,"I just hugged them... and ... parents landed at Vancouver airport last week. ,Dhaval ... Gujarat advised him to move after looking at his condition ...
... It was just weeks following the 9/11 attacks in ... offices of the news media and two US senators//. The ... five people and infected 17 others. , ,In a ... University of Georgia, teaming up with scientists at the federal ...
... and at times even forbid birthday cupcakes due to ... bring carrots," said Laura Ott, assistant to the superintendent.,A ... a sticker and a pencil instead of sweets from ... Unified School District, in Orange County, Calif., has restricted ...
Cached Medicine News:Health News:Indian with Rare Disorder Reunited with Family 2Health News:Cell-Wall Carbohydrate in Anthrax Bacterium Holds Promise for New Vaccines 2
(Date:8/4/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/bqfsp3/transdermal_drug ... PharmaBiotech,s new report "Transdermal Drug Delivery ... their offering. This report ... approach used to deliver drugs through the ... to oral,intravascular, subcutaneous and transmucosal routes. Various ...
(Date:8/4/2015)... -- Concord Medical Services Holdings Limited ("Concord Medical", or the ... and operator of the largest network of radiotherapy and diagnostic ... it will release its financial results for the second quarter ... Management will hold a conference call to discuss ... August 18, 2015 (8:00 p.m. in Beijing ...
(Date:8/4/2015)... 4, 2015 P&S Market ... overview, trends, DRO analysis, market segmentation, market size ... and top competitor profiles in: Global ... Development and Demand Forecast to 2020  ... Explore full reports with detailed TOC on Global ...
Breaking Medicine Technology:Transdermal Drug Delivery Report 2015-2024 - Technologies, Markets, and Companies Analysis 2Concord Medical to Report Second Quarter 2015 Financial Results on August 17, 2015 2Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 2Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 3Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 4Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 5
... (OTC Bulletin Board: TBIO ) announced today ... Inc.,s (Nasdaq: CLDA ) diagnostic business with ... company has closed on $6.0 million of financing from ... to fund the cash portion of Transgenomic,s acquisition of ...
... FAIRVIEW, Pa., Dec. 29, 2010 Spectrum Control, Inc. (Nasdaq: ... custom electronic products and systems, announced today that it will ... Monday, January 10, 2011, after the close of the market. ... at 4:45 PM, Eastern Time, to discuss the Company,s operating ...
Cached Medicine Technology:Transgenomic Announces Closing of the Acquisition of Clinical Data's Diagnostic Business and the Closing of a $6 Million Financing 2Transgenomic Announces Closing of the Acquisition of Clinical Data's Diagnostic Business and the Closing of a $6 Million Financing 3Transgenomic Announces Closing of the Acquisition of Clinical Data's Diagnostic Business and the Closing of a $6 Million Financing 4
Gentle curve facilitates less traumatic removal from eye. Increased length ideal for myopic eyes...
Great for small incisions and excision needs...
Cannula: .90mm x 28mm (20 G x 1 1/8 in) Handle: 9.3cm (3 5/8 in) long, Flute, .90 x 28mm, vacuum handle [Charles]...
2.5mm...
Medicine Products: