Navigation Links
Natural method for clearing cellular debris provides new targets for lupus treatment
Date:2/24/2012

Augusta, Ga. Cells that die naturally generate a lot of internal debris that can trigger the immune system to attack the body, leading to diseases such as lupus.

Now Georgia Health Sciences University researchers report that an enzyme known to help keep a woman's immune system from attacking a fetus also helps block development of these autoimmune diseases that target healthy tissues, such as DNA or joints.

The findings point toward new treatment strategies for autoimmune diseases, which are on the rise in light of a germ-conscious society that regularly destroys many of the previously pervasive microbes that made the immune system more tolerant.

"The basic premise of lupus is you have lost normal tolerance to yourself, your own proteins and DNA," said Dr. Tracy L. McGaha, GHSU immunologist and corresponding author of the study published in Proceedings of the National Academy of Sciences.

They found that IDO, or indoleomine 2,3-dioxegenase, helps promote tolerance to debris generated by natural cell death and that when IDO is removed from the mix, the debris spurs an immune response that can trigger autoimmune disease. In mice genetically programmed to develop lupus, blocking IDO resulted in earlier, more aggressive disease.

"This connects IDO and macrophages. It's a newly described role for IDO in regulation of tolerance toward self," McGaha said. Consequently, increasing IDO production or its downstream effects might be a way to regain lost tolerance, he said.

They studied activity in the spleen, a hard-working immune organ, that constantly filters blood. In a perfectly orchestrated defense, the entrance to the spleen is surrounded by immune cells that scour blood for viruses, bacteria, even fat and cholesterol floating by.

A nearby subset of macrophages, which are essentially scavengers, then capture and consume the undesirables, McGaha said. Interestingly, a lot of what macrophages consume is dead immune cells.

Macrophages also appear to help keep the peace by preventing the immune system from joining the fray. McGaha earlier found that if he destroyed macrophages, then fed the spleen dead cells, there was inflammation instead of calm. "That tells us there is something inherent in this subset of macrophages that is important for the suppressive process," McGaha said referencing the paper published in 2011 in the journal Blood.

The new paper shows IDO is part of that "something." Efficient elimination of cell debris while keeping nearby immune cells quiet is important because some debris is known to grab the attention of the immune system, McGaha said. He noted that it's normal and healthy for damaged cells to become targets.

"We are really interested in this process of normal cell debris removal because in lupus, it's thought to be one of the main drivers of inflammation," he said.

The immune system has points of expansion and regulation where it decides whether or not to act. Knowing key points, such as IDO's regulatory role, provides treatment targets that can interrupt a destructive cascade of immune activity, McGaha said. Previous studies have shown evidence of self-attack is present many years before disease symptoms appear, he said.

Environmental assaults, such as a bad sunburn, can be the initial trigger of the abnormal immune response in diseases like lupus. In healthy individuals, the immune system rises to the occasion of an infection then goes back to baseline. In autoimmune disease, patients tend not to return to normal levels.

GHSU's Drs. Andrew Mellor and David Munn reported in 1998 in the journal Science that the fetus expresses IDO to help avoid rejection by the mother's immune system. Subsequent studies have shown tumors also use it and that it could help transplanted organs escape rejection. They suggested that McGaha look at IDO as a regulatory mechanism used by macrophages.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert

Related medicine news :

1. Natural enzyme provides potential new approach for treating graft-vs.-host disease
2. A natural dye obtained from lichens may combat Alzheimers disease
3. Natural killer cells could be key to anthrax defense
4. New scarless surgery takes out tumors through natural skull opening
5. BU presents approach to access biorelevant structures by remodeling natural products
6. Natural processes can limit spread of arsenic in water, says study
7. Soy-based natural S-equol supplements improve crows feet skin wrinkles in menopausal women
8. For Kids, Natural Disasters Can Whip Up Worries
9. Bodys natural marijuana-like chemicals make fatty foods hard to resist
10. Study shows pine bark naturally improves heart function
11. Cooling system may build eggs natural defenses against salmonella
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2017)... ... May 29, 2017 , ... A New York high tech ... month test of the effectiveness of Artificial Intelligence (AI) in helping nudge men forward ... game,’ said Wayne Hartrick, President of the Canadian Men’s Health Foundation (CMHF), whose mission ...
(Date:5/28/2017)... ... May 28, 2017 , ... ... proud to announce that Sheldon K. Cho, MD, has joined its Winter Haven ... specialty that concentrates on minimally invasive techniques to treat and manage many types ...
(Date:5/27/2017)... ... 2017 , ... From May 21-23, hearing healthcare professionals gained a competitive edge ... the Marriott Syracuse Downtown Hotel in Syracuse, New York. , As EarQ’s technology ... healthcare providers to help them stay ahead in the industry. At the event, EarQ ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... new educational seminar to focus on current legislative activity and the latest regulatory ... at 1 p.m. Sunday, Sept. 10, and will continue through Monday, Sept. 11, ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... the first ever copper, antimicrobial, mesh back 24/7 task chair specifically designed for ... applications. “We are thrilled to partner with Cupron® to provide customers with ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... 22, 2017  As the specialty pharmacy industry ... to make the revolutionary shift from volume-based to ... ensuring positive patient outcomes and shaping the future ... focus away from clinical trials and toward data ... specialty drug therapy utilization in precise patient populations. ...
(Date:5/12/2017)... May 12, 2017  The China and Canada ... that consumes less water, energy and detergent, and features a powerful ... LaughingU, a shoebox-sized washing machine that washes and sanitizes women,s panties ... ... is compact, and does not require an external water inlet. ...
(Date:5/10/2017)... -- Radiology has become the number one diagnostic tool ... to the number one ranking as a result.  More ... as the most complete and reliable method for clinical ... pain an MRI may confirm a suspected herniated disc ... entirely different treatment protocols.  In these circumstances, patients need ...
Breaking Medicine Technology: