Natural aorta grafts have few side effects for infection-pron... (graft infections and we were pleased to ...)

Natural aorta grafts have few side effects for infection-prone patients

Date:9/10/2007

graft infections, and we were pleased to see few long-term side effects for patients who have received these grafts.

In addition, the researchers found that natural grafts are not nearly as prone to infection and later failure due to blockage of the graft.

The study examined 180 patients who underwent arterial reconstructions using deep-vein grafting at UT Southwestern. Of those surveyed, 85 percent reported no venous complications flow in the leg. A minority of patients (7.5 percent) reported mild swelling in the leg, and the remaining 7.5 percent reported moderate, but manageable, symptoms.

These results are astounding, particularly when one considers that most of the patients were facing life- or limb-threatening problems when they arrived at our institution, Dr. Modrall said.

In addition to a detailed interview, researchers performed a physical examination, ultrasound testing and venous physiological testing on each limb after deep-vein harvest. Few differences were noted between the legs that had been operated upon and those that had not.

Venous complications in the legs, known as venous insufficiency, can include swelling, skin discoloration and open wounds. We were reassured to find that even mild venous complications are quite unusual after removing the deep veins of the legs to treat these difficult graft infections, Dr. Modrall said. Our hope here is to reassure surgeons who face these complex cases that deep-leg-vein grafts are an acceptable even preferable alternative to replacing a synthetic graft with another synthetic graft.

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Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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