Navigation Links
Natural aorta grafts have few side effects for infection-prone patients

DALLAS Sept. 10, 2007 A vascular surgery technique pioneered at UT Southwestern Medical Center, in which veins are removed from the thigh to repair the aorta does not create blood-flow problems and painful side effects in a majority of patients, researchers report.

Vascular disease is a major contributor to life-threatening conditions such as aneurysms or blockages of the aorta. Inserting synthetic grafts to repair damaged aortas, the largest artery in the body, is typically the first line of treatment.

Some patients, however, are prone to infections in these grafts, which typically requires removal of the infected grafts, a surgery that leaves the patient with no blood flow to the legs. Searching for a solution to this dilemma, surgeons at UT Southwestern, led by Dr. Patrick Clagett, chairman of vascular surgery, developed a technique in the early 1990s that uses veins from a patients own leg to fix and repair infected grafts.

Dr. Clagett and his colleagues recently reviewed the results of those grafts and found that patients had few side effects and fared well in the long-term after receiving grafts from their own bodies. He reports his findings in the September issue of the Journal of Vascular Surgery.

Most patients with synthetic aortic grafts experience favorable outcomes, but for the small percentage of patients who develop chronic infections within the graft that do not respond to antibiotics, they are at risk of losing their legs or dying.

Since the veins of the leg return blood flow to the heart, there was concern that harvesting the deep veins from the thigh to repair synthetic aortic grafts could lead to problems with pooling of blood in the leg, said Dr. Greg Modrall, associate professor of surgery at UT Southwestern and the lead author of the study. Using the deep vein as an arterial graft, which was popularized by the senior author of this study, Dr. Clagett, has revolutionized the way we approach graft infections, and we were pleased to see few long-term side effects for patients who have received these grafts.

In addition, the researchers found that natural grafts are not nearly as prone to infection and later failure due to blockage of the graft.

The study examined 180 patients who underwent arterial reconstructions using deep-vein grafting at UT Southwestern. Of those surveyed, 85 percent reported no venous complications flow in the leg. A minority of patients (7.5 percent) reported mild swelling in the leg, and the remaining 7.5 percent reported moderate, but manageable, symptoms.

These results are astounding, particularly when one considers that most of the patients were facing life- or limb-threatening problems when they arrived at our institution, Dr. Modrall said.

In addition to a detailed interview, researchers performed a physical examination, ultrasound testing and venous physiological testing on each limb after deep-vein harvest. Few differences were noted between the legs that had been operated upon and those that had not.

Venous complications in the legs, known as venous insufficiency, can include swelling, skin discoloration and open wounds. We were reassured to find that even mild venous complications are quite unusual after removing the deep veins of the legs to treat these difficult graft infections, Dr. Modrall said. Our hope here is to reassure surgeons who face these complex cases that deep-leg-vein grafts are an acceptable even preferable alternative to replacing a synthetic graft with another synthetic graft.


Contact: Katherine Morales
UT Southwestern Medical Center

Related medicine news :

1. Unnatural death common in mentally ill
2. Eczema patients lack natural antibiotic in skin
3. Accuracy of Some Natural Family Planning Methods Questioned .
4. Natural formula for protection against vision loss
5. Naturally Occurring Hormone Can Lead To Miscarriage
6. Treating Leukemia With Natural Cells
7. The effects of Curcumin: a natural pigment in turmeric explored for its anti-cancer properties
8. Natural Sulfur Can Treat Pain From Osteoarthritis
9. Chronic Post-Traumatic Stress Disorder (PTSD) Risk In Young Natural Disaster Survivors
10. Tsunami Unplugged: Natural Disasters Favor the Under-privileged
11. Studies Advocate Natural Form Of Vitamin E
Post Your Comments:
(Date:6/27/2016)... Brooklyn, NY (PRWEB) , ... June 27, 2016 ... ... is using cutting edge technology to revolutionize the emergency ambulance transport experience for ... Many are aware of how Uber has disrupted the taxi industry through the ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: