Natural aorta grafts have few side effects for infection-pron...( DALLAS Sept. 10 2007 A vascular su...),Health

DALLAS Sept. 10, 2007 A vascular surgery technique pioneered at UT Southwestern Medical Center, in which veins are removed from the thigh to repair the aorta does not create blood-flow problems and painful side effects in a majority of patients, researchers report.

Vascular disease is a major contributor to life-threatening conditions such as aneurysms or blockages of the aorta. Inserting synthetic grafts to repair damaged aortas, the largest artery in the body, is typically the first line of treatment.

Some patients, however, are prone to infections in these grafts, which typically requires removal of the infected grafts, a surgery that leaves the patient with no blood flow to the legs. Searching for a solution to this dilemma, surgeons at UT Southwestern, led by Dr. Patrick Clagett, chairman of vascular surgery, developed a technique in the early 1990s that uses veins from a patients own leg to fix and repair infected grafts.

Dr. Clagett and his colleagues recently reviewed the results of those grafts and found that patients had few side effects and fared well in the long-term after receiving grafts from their own bodies. He reports his findings in the September issue of the Journal of Vascular Surgery.

Most patients with synthetic aortic grafts experience favorable outcomes, but for the small percentage of patients who develop chronic infections within the graft that do not respond to antibiotics, they are at risk of losing their legs or dying.

Since the veins of the leg return blood flow to the heart, there was concern that harvesting the deep veins from the thigh to repair synthetic aortic grafts could lead to problems with pooling of blood in the leg, said Dr. Greg Modrall, associate professor of surgery at UT Southwestern and the lead author of the study. Using the deep vein as an arterial graft, which was popularized by the senior author of this study, Dr. Clagett, has revolutionized the way we approach
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