Navigation Links
Natural Secretion Marks Difference Between Ordinary Mole and Melanoma
Date:2/7/2008

IGFBP7 protein may prove a targeted treatment for metastatic cancers, study suggests

THURSDAY, Feb. 7 (HealthDay News) -- An anti-cancer protein that's naturally produced and secreted by the body can make the difference between a common mole and deadly melanoma skin cancer, a new study says.

If this IGFBP7 protein can be produced and delivered to tumors, it may prove effective as a targeted treatment for metastatic melanoma, which is currently untreatable. It may also prove useful in treating other cancers with mutations in the BRAF oncogene, said Michael Green, a Howard Hughes Medical Institute investigator at the University of Massachusetts Medical School.

Mutations that cause permanent activation of BRAF occur in as many as 70 percent of melanoma cases. These mutations, also found in some colorectal, ovarian and lung cancers, are associated with cell proliferation and tumor growth.

But up to 82 percent of benign moles also contain BRAF-activating mutations. Green and his colleagues investigated the differences between benign moles and melanoma in mice and zeroed in on the IGFBP7 protein.

"This is a natural mechanism by which cells try to prevent cancer. The secretion of this protein gets lost in the formation of cancer. But, because it is secreted, it might also be converted to a therapeutic," Green said in a prepared statement.

Last year, melanoma killed more than 8,000 people in the United States.

The study findings were published in the Feb. 8 issue of the journal Cell.

More information

The U.S. National Cancer Institute has more about melanoma.



-- Robert Preidt



SOURCE: Cell Press, news release, Feb. 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Nordic Naturals Professional Exclusive Division Redefines High Potency Omega-3 Supplementation With New Elite Line!
2. Better Nutrition Announces Best Of Beauty Awards Winners Showcasing the Best Natural Beauty Products of 2008
3. Natural Nutrition Operating Subsidiary Reports Record 29% Increase in Revenues for 2007 of $17,460,000
4. Wild Childs Quit Nits Offers a Safe, Natural Alternative to Current Toxic Head Lice Products
5. Natural Nutrition Announces Forward Split of Common Stock
6. Super Food Bowl Animation From NaturalNews.com Teaches Kids to Avoid Junk Foods, Pursue Natural Nutrition
7. Natural Nutrition Launches All Natural FUSION Fruit Bar Line
8. Synthesis of natural molecule could lead to better anti-cancer drugs
9. Natural Harmony Foods Works to Reduce Childhood Obesity
10. Turnaround Partners Sells Minority Ownership in Interactive Nutrition to Natural Nutrition
11. January American Naturalist highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... ... Footwear Foundation, the national charitable foundation serving the footwear industry, has broken all ... representing more than 130 companies across 23 states during the months of April ...
(Date:4/29/2016)... ... April 29, 2016 , ... Our bodies are bombarded daily by environmental ... deal with these stressors is to adopt a more healthful diet, but too many ... Groux, a certified Holistic Nutritionist and the creator of the Newport Beach Cleanse and ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. Bernie ... best seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to Death live ... thereafter . Dr. Bernie Siegel, author of a plethora of essential books-to-read ...
(Date:4/29/2016)... ... April 29, 2016 , ... Coast Dental Fort Stewart is ... its new location in the Exchange Furniture Mall at 112 Vilseck Road in Fort ... Samsung Smart TV. Plus attendees will have the opportunity to meet general dentists Thomas ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... that student team BioCellection won the $30,000 Perlman Grand Prize of the 2016 ... Gloeckner Undergraduate Award, the Michelson People’s Choice Award, and the Committee Award for ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... NEW YORK , April 28, 2016 ... of online consumer insights on healthcare, announced today that ... in their report Cool Vendor in Life Sciences, ... , April 15, 2016.  The report focuses on life-science- ... to gain insight from patients and doctors, confirm medication ...
(Date:4/28/2016)... Dr. Vivek Ahuja , ... phen Schmidt Join the Growing ... solutions for life sciences, today announced key new leaders have joined ... to a growing business.  This will bolster the company,s safety business ... joined ArisGlobal in the position of Vice President - Safety. George ...
(Date:4/28/2016)...   Acsis , a leading provider of supply ... research and advisory firm IDC has named it a ... Pharmaceutical Track and Trace Software 2016 Vendor Assessment (doc ... of the capabilities and business strategies of 10 vendors ... Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
Breaking Medicine Technology: