Navigation Links
Natural Secretion Marks Difference Between Ordinary Mole and Melanoma
Date:2/7/2008

IGFBP7 protein may prove a targeted treatment for metastatic cancers, study suggests

THURSDAY, Feb. 7 (HealthDay News) -- An anti-cancer protein that's naturally produced and secreted by the body can make the difference between a common mole and deadly melanoma skin cancer, a new study says.

If this IGFBP7 protein can be produced and delivered to tumors, it may prove effective as a targeted treatment for metastatic melanoma, which is currently untreatable. It may also prove useful in treating other cancers with mutations in the BRAF oncogene, said Michael Green, a Howard Hughes Medical Institute investigator at the University of Massachusetts Medical School.

Mutations that cause permanent activation of BRAF occur in as many as 70 percent of melanoma cases. These mutations, also found in some colorectal, ovarian and lung cancers, are associated with cell proliferation and tumor growth.

But up to 82 percent of benign moles also contain BRAF-activating mutations. Green and his colleagues investigated the differences between benign moles and melanoma in mice and zeroed in on the IGFBP7 protein.

"This is a natural mechanism by which cells try to prevent cancer. The secretion of this protein gets lost in the formation of cancer. But, because it is secreted, it might also be converted to a therapeutic," Green said in a prepared statement.

Last year, melanoma killed more than 8,000 people in the United States.

The study findings were published in the Feb. 8 issue of the journal Cell.

More information

The U.S. National Cancer Institute has more about melanoma.



-- Robert Preidt



SOURCE: Cell Press, news release, Feb. 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Nordic Naturals Professional Exclusive Division Redefines High Potency Omega-3 Supplementation With New Elite Line!
2. Better Nutrition Announces Best Of Beauty Awards Winners Showcasing the Best Natural Beauty Products of 2008
3. Natural Nutrition Operating Subsidiary Reports Record 29% Increase in Revenues for 2007 of $17,460,000
4. Wild Childs Quit Nits Offers a Safe, Natural Alternative to Current Toxic Head Lice Products
5. Natural Nutrition Announces Forward Split of Common Stock
6. Super Food Bowl Animation From NaturalNews.com Teaches Kids to Avoid Junk Foods, Pursue Natural Nutrition
7. Natural Nutrition Launches All Natural FUSION Fruit Bar Line
8. Synthesis of natural molecule could lead to better anti-cancer drugs
9. Natural Harmony Foods Works to Reduce Childhood Obesity
10. Turnaround Partners Sells Minority Ownership in Interactive Nutrition to Natural Nutrition
11. January American Naturalist highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... ... An inventor from Cana, Va., wanted to fulfill the need for a ... , The patent-pending SAFETY STRAP FOR AMPUTEES improves accessibility. It eliminates discrimination. It is ... in a matter of minutes, or even seconds. The SAFETY STRAP FOR AMPUTEES is ...
(Date:12/9/2016)... (PRWEB) , ... December 09, 2016 , ... "I had ... an inventor from Winchester, Va. "I thought that if the nebulizer had a more ... rather than fearing them." , He developed the patent-pending NEBY to avoid the need ...
(Date:12/8/2016)... ... December 08, 2016 , ... After ... officially opened registration today for its 33rd Annual Issues & Research Conference, ... , The theme of the conference is “Persistent Challenges and New Opportunities: Using ...
(Date:12/8/2016)... Reston, Virginia (PRWEB) , ... December 08, 2016 ... ... and services company offering Medication Therapy Management (MTM), adherence, and other pharmacist-delivered patient ... of operations and general counsel and Eric Hoessel to vice president of sales. ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... Premier Fitness ... Chopra FIT , the ultimate weight loss and wellness program, at their world headquarters ... developed to provide immediate and long-term results to anyone seeking weight loss, personal development, ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016  The global biosurgery market is expected to ... period of 2016 to 2021. The market is poised ... 18.21 billion in 2016. The market is primarily driven ... related injuries and spinal problems, increasing clearance of biosurgery ... blood loss management. In this report, the ...
(Date:12/8/2016)... KEY FINDINGS The global medical ... Various reasons for growth of the medical lifting sling ... chronic diseases, high recovery cost of injuries and government ... lifting sling refers to an assistive device that helps ... connect to the lift and hold the patient. It ...
(Date:12/8/2016)... Pharmacy, Inc. (NYSE: DPLO) has been recognized by the Detroit ... Standard. To learn more about Diplomat,s career opportunities, visit ... ... ... LLC, a research firm specializing in organizational health and workplace improvement. ...
Breaking Medicine Technology: