Navigation Links
National study of nanomaterial toxicity sets stage for policies to address health risks
Date:5/5/2013

For the first time, researchers from institutions around the country have conducted an identical series of toxicology tests evaluating lung-related health impacts associated with widely used engineered nanomaterials (ENMs). The study provides comparable health risk data from multiple labs, which should help regulators develop policies to protect workers and consumers who come into contact with ENMs.

Researchers have done a great deal of toxicological research on ENMs over the past 10 years, but the results have often been difficult to interpret. This is because ENMs from different sources had different chemical and physical properties, and because investigators used different protocols to conduct the experiments.

"The goal of creating this multicenter consortium was to have multiple labs recreate key studies using the same materials and protocols, so that policy-makers have access to consistent, comparable results from multiple institutions," says Dr. James Bonner, an associate professor of environmental and molecular toxicology at NC State and lead author of a paper describing the work.

For this study, researchers from eight institutions used mouse and rat models to look at pulmonary health effects related to exposure to titanium dioxide nanoparticles and carbon nanotubes.

The researchers found that carbon nanotubes, which are used in everything from bicycle frames to high performance electronics, produced inflammation and inflammatory lesions in the lower portions of the lung. However, the researchers found that the nanotubes could be made less hazardous if treated to remove excess metal catalysts used in the manufacturing process or modified by adding carboxyl groups to the outer shell of the tubes to make them more easily dispersed in biological fluids.

The researchers also found that titanium dioxide nanoparticles also caused inflammation in the lower regions of the lung. Belt-shaped titanium nanoparticles caused more cellular damage in the lungs, and more pronounced lesions, than spherical nanoparticles.

"The findings are significant, but the real take-away message here is that the multicenter consortium concept works and that means this is a starting point for assessing nanomaterials using this approach," Bonner says. "I'm optimistic that this will serve as a blueprint for similar efforts, which will give regulators comparable data across institutions that will be easier for them to interpret."


'/>"/>

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert

Related medicine news :

1. MU receives national award for using mind-body approach to improve health
2. International breast health global summit will focus on supportive care and quality of life
3. International conference to explore health of descendants of transatlantic slave trade
4. National poll: Low cost, lifesaving services missing from most older patients health care
5. UT MD Anderson President Ronald DePinho elected to National Academy of Sciences
6. Kessler Foundation researchers present at first International Congress on Cognition in MS
7. Dr. Yael Mosse will receive first Nachman Award in Pediatric Oncology at national conference
8. Georgetown physician leads national resveratrol study for Alzheimers disease
9. National initiative launched to change the way biology departments approach undergraduate education
10. Boston researcher, surgical oncologist receives national award
11. Internationally known expert in ovarian cancer to be honored at the ASCO Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... ... a part of the city where’s it’s easy to spot the neon lights of chains ... to attract diners with a taste for real food. , On May 13, the ... Grill, an urban casual restaurant focusing on dishes made by hand with wholesome, organic ingredients ...
(Date:5/27/2016)... New Hampshire (PRWEB) , ... May 27, 2016 , ... ... skin care products, announced today that it has been recognized as one of the ... entering parenthood. Badger was named as one of nine small businesses providing progressive benefits ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational ... by inspiring human-interest stories, courtesy of awareness-driven celebrities and thought leaders. It also ... advocates, associations and industry leaders such as Bioness. , As patients feel ...
(Date:5/27/2016)... ... ... Aimed at nurses and employees in the health care world, this installment ... nursing and health care industry. It also provides insight to the developing trends and ... As the nursing industry is coming out of one of the biggest recessions in ...
(Date:5/26/2016)... ... May 26, 2016 , ... There are many ways ... and Sausage Council (NHDSC) suggests that Americans prefer their dogs straight off the grill. ... say grilling is their favorite way to cook a hot dog, far outpacing other ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... May 30, 2016 According ... Testing Services Market by Type (Stability, Raw Materials, ... End User (Pharmaceutical Companies, Medical Device Companies) - ... market witnessed healthy growth during the last decade ... of 11.3% between 2016 and 2021 to reach ...
(Date:5/30/2016)... On 28 May, 194 Member States ... At the 69 th World Health Assembly, governments unanimously ... signalling the greatest global commitment in viral hepatitis to date. ... B and C by 2030 and includes a set of ... deaths by 65% and increase treatment to 80%, saving 7.1 ...
(Date:5/30/2016)... PUNE, India , May 30, 2016 /PRNewswire/ ... Pipeline Review, H1 2016" market research report with ... Colitis, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ... press releases. It also reviews key players involved ...
Breaking Medicine Technology: