Navigation Links
National Jewish Health researchers awarded $13 million to evaluate treatments for toxic gases
Date:10/13/2011

National Jewish Health researchers have received nearly $13 million from the National Institutes of Health to evaluate potential rescue medications for victims of terrorist attacks, wartime use of toxic gases, and/or inhalation disasters. The gases of greatest interest in these studies will be 'mustard gas' (sulfur mustard) and chlorine gas.

"The excitement about these studies is that they are designed to provide rescue treatments," said Carl White, MD, principal investigator of the grant.

The grant, part of the NIH's Countermeasures Against Chemical Threats Research Network (CounterACT), is for 5 years. The rescue agents to be given greatest study in these trials will include fibrinolytics ('clot busters'), anticoagulants, catalytic antioxidants, and flavonoids (specific herbal remedies). Researchers will evaluate models of damage to the lungs and airways and to skin.

"We have already found very encouraging preliminary data in which some of our agents can be effective even when given several hours after the toxic inhalation," said Dr. White. "This is important because real world conditions can cause minutes to hours of delay in getting to victims of such tragedies."

The work involves collaborations between two teams of investigators at National Jewish Health and one from the University of Colorado School of Pharmacy, as well as a collaborating center at the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD).

"The drugs we are testing work through several different mechanisms so that they may prevent or limit progressive damage to airways or skin, as well as prevent or clear blockage of airways," said Dr. White. "It is also exciting that some of the treatments we develop may also carry over to other difficult lung diseases of childhood and adults."

The initial focus of the research is on the acute injury to lungs and skin occurring in the first 24-48 hours of exposure. As the studies progress over the next several years, researchers hope to evaluate the ability of our relatively early interventions to prevent lung fibrosis and bronchiolitis obliterans that can result from such exposures.


'/>"/>
Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Related medicine news :

1. NationalCreditReport.com Reminds Consumers of Ways to Improve Credit Report and Score in 2010
2. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
3. National Wildlife Federation Says Outdoor Time for Kids Can Help First Lady Achieve Her “Let's Move” Goal
4. Howard Dean to Speak at the 2010 DTC National Conference
5. International Diabetes Federation awards $2 million to 9 global diabetes research projects
6. Jion Beijing Great Wall International Travel Agency Immediate Exposure to China Expo 2010
7. U.S. National Guard Connects Nationwide with Desktop Alert's Command and Control Mass Notification Systems and Common Alerting Protocol (CAP)
8. H1N1 international symposium to be hosted by Emory-UGA Influenza Center
9. The Alliance for a Healthier Generation Names Celtics Captain Paul Pierce National Athlete Spokesperson in the Fight Against Childhood Obesity
10. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
11. Protecting patients: Study shows that Johns Hopkins flu vaccination rates twice national average
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... Salt Lake City, UT (PRWEB) , ... April 28, 2017 , ... ... that exist in some of their formulas. This begins with the popular ClearLungs Extra ... impacted, they will be changing the formula in the following ways:, ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... http://www.foodsthathealdaily.com , http://www.wiredlifesolutions.com , “Computers are everywhere and they’re here to ... of Water, Global Climate Change and Your Health on Voice America sponsored by ...
(Date:4/28/2017)... ... April 28, 2017 , ... Children and ... more adverse experiences than children in the general population. That’s because foster care ... or other family challenges. While no fault of their own, youth who have ...
(Date:4/28/2017)... ... , ... People are starting to accept that hearing aids can be helpful ... stigma it had when great-grandpa wore his hearing aids years ago,” said Dr. Maura ... North American Speaker Series (NASS) segment. “He probably wore an iPod-size hearing aid ...
(Date:4/28/2017)... ... April 28, 2017 , ... Phytomer ... East region. Côté has 20+ years of experience within the beauty industry, ranging ... with an array of high-end cosmetic brands, retail brands and outlets in Canada ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... LONDON , April 19, 2017 ... to stimulate an immune response in pets such ... vaccine products are of various types such as ... Vaccines, Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. ... such as virus or bacteria, which have been ...
(Date:4/18/2017)... Ohio , April 18, 2017  Cardinal Health ... Non-GAAP 1 fiscal 2017 earnings per share (EPS) ... and 2019.  This is in conjunction with this morning,s ... Deep Vein Thrombosis and Nutritional Insufficiency businesses. ... from continuing operations will be at the bottom of ...
(Date:4/18/2017)... -- Astute Medical, Inc., developer of biomarkers for better healthcare, ... the 2017 National Kidney Foundation (NKF) Spring Clinical ... 22. Physicians will present data on two biomarkers, ... acute kidney injury (AKI) during the management of patients ... Elevated levels of TIMP-2 and IGFBP-7 have been shown ...
Breaking Medicine Technology: