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Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals

ational to provide crofelemer for pediatric populations in disaster situations in resource-constrained geographies, pending receipt of a new drug approval for crofelemer from the FDA.


Despite the advent of anti-retroviral (ARV) therapy, chronic diarrhea continues to be a hallmark of HIV/AIDS. More than 1 million people with HIV are currently in the United States, and 15-30% are managing diarrhea chronically.

There are many reasons to treat diarrhea in people with HIV/AIDS, and the documented medical importance for doing so enhances the financial opportunities in such market. These reasons include:

    -- intolerability of chosen course of therapy, resulting in the need to
       switch therapy;
    -- decreased absorption of drugs, and poor adherence to drug regimen due
       to side-effect of diarrhea, indirectly increasing risk of emergence of
       resistant HIV strains;
    -- higher cost of managing HIV/AIDS in those suffering with chronic
    -- difficulty in maintaining nutritional status of patient; and
    -- quality of life issues.

Compared to the limited therapeutic options available for the management of chronic diarrhea, crofelemer has no motility related side-effects, is hardly absorbed systemically (acts locally in the gut), and has an excellent safety profile.


Diarrheal diseases are a major cause of child mortality and morbidity. Each year, 4 billion cases of diarrhea occur worldwide, causing 2-3 million deaths among children under five years. Cholera, the most severe of diarrheal diseases, is an ongoing pandemic and the number of affected countries continues to increase, especially in Africa.

The morbidity caused by diarrheal diseases is increasing. Children under 5 in developing countries suffer on ave

SOURCE Napo Pharmaceuticals, Inc.
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