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Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals
Date:12/10/2008

of severe cholera, and in increasing pain-discomfort-free days in diarrhea-predominant IBS patients, were released earlier this year. Crofelemer has demonstrated an excellent safety profile across all indications, both with chronic and acute administration. Crofelemer is sustainably harvested from the Amazonian tree, Croton lechleri, in several countries in South America.

Crofelemer product labeling by Salix (or its affiliates, sub-licensees or distributors as defined in the Collaboration Agreement) will include a reference to Napo as the licensor and will include Napo's logo and refer to the sustainable supply of crofelemer, to the extent legally allowed.

This collaboration allows Napo to proceed with its mission to provide global access to novel, branded pharmaceuticals. Diarrheal diseases are a major cause of child mortality and morbidity. Each year, 4 billion cases of diarrhea occur worldwide, causing 2-3 million deaths among children under five years.

Crofelemer is also licensed to Glenmark Pharmaceuticals, Ltd. of Mumbai, India in 140 emerging and developing countries for diarrhea indications; and to AsiaPharm, Ltd. in greater China for diarrhea indications. In conjunction with this license to Salix, Glenmark and Salix have entered into a commercial supply agreement for crofelemer API (active pharmaceutical ingredient).

Lisa Conte, Napo founder and CEO, commented, "Salix is an important force in providing solutions and expertise in the gastro-intestinal field. We are thrilled to have their leadership, skill, and committed resources to bring crofelemer first to the HIV community in the US. Ultimately, this license and Salix's international network in the gastro-intestinal field can provide global access of crofelemer to all populations for all indications."

Earlier this year, Napo announced, as part of the Crofelemer Access Program, an alliance with Direct Relief Intern
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SOURCE Napo Pharmaceuticals, Inc.
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