Navigation Links
Nanowire coating for bone implants, stents
Date:8/27/2007

FAYETTEVILLE, Ark. - University of Arkansas researchers have found a simple, inexpensive way to create a nanowire coating on the surface of biocompatible titanium that can be used to create more effective surfaces for hip replacement, dental reconstruction and vascular stenting. Further, the material can easily be sterilized using ultraviolet light and water or using ethanol, making it useful in hospital settings and meat-processing plants

Wenjun Dong, Tierui Zhang, Lisa Cooney, Hong Wang, Yanbin Li, Andrew Cogbill, Vijay Varadan and Z. Ryan Tian of the University of Arkansas, Ying-Bing Jiang of the University of New Mexico, and Joshua Epstein of the University of Arkansas for Medical Sciences report their findings in an upcoming issue of the journal Chemistry of Materials.

The researchers used an alkali and heat to create titanium oxide-based ceramic nanowires that coat the surface of a titanium medical device.

"We can control the length, the height, the pore openings and the pore volumes within the nanowire scaffolds" by varying the time, temperature and alkali concentration in the reaction, said Z. Ryan Tian, assistant professor of chemistry and biochemistry in the J. William Fulbright College of Arts and Sciences. "This process is also extremely sustainable," requiring only that the device be rinsed in reusable water after the heating process.

Reconstructive bone surgeries, such as hip replacements, use titanium implants. However, muscle tissue may not adhere well to titanium's smooth surface, causing the implant to fail after a decade or so and requiring the patient to undergo a second surgery.

Tian and his colleagues created a nanowire-coated joint and placed it in mice. After four weeks, the researchers found that tissue had adhered to the joint.

"We saw beautiful tissue growth - lots of muscle fibers," Tian said. "We've added one more function to the currently-in-use titanium implant."

Because the researchers can control the size and shape of the pores in the nanowire scaffold, the material also could be coated onto stents used in patients with coronary artery disease and in potential stroke victims. Conventional stents sometimes become reclogged with fat after implantation. The most recent stent used to address this problem, called the drug-eluting stent, consists of a polymer coating mixed with the drugs, but the coating may be vulnerable to biodegradation, and may not function for long. The nanowire coating without the degradation problem could be used to carry drugs that would help keep the arteries clear over a long period of time.

"This drug release could be applied to the angioplasty catheter's surface," Tian said.

In addition to these biomedical applications, the nanofiber scaffold has a property that may make it useful in both hospitals and food processing plants: The material, when rinsed in water and exposed to ultraviolet light, kills more than 99 percent of bacteria on its surface. This effect occurs because photons from the light cause a charge separation on the material, splitting water molecules into free radicals that destroy the bacteria. Alternatively, immersion in 70 percent ethanol completely sterilizes the material, allowing growth of cells/tissues in the laboratory prior to implantation.

This property could prove extremely useful in bacteria-prone environments, performing such functions as sterilizing on-site surgery hospitals used during military actions or cleaning surfaces in meat-processing plants.

"You could just use water to rinse and UV light to sterilize surfaces," Tian said.

The researchers have applied for a provisional patent for the multifunctional nanowire bioscaffolds on titanium or titanium-containing alloys such as Nitinol.


'/>"/>
Contact: Melissa Lutz Blouin
blouin@uark.edu
479-575-5555
American Chemical Society
Source:Eurekalert

Related medicine news :

1. Aloe Vera Coating For Fruits And Vegetables Preservation
2. Anti-Microbial Coating For Use Over Biomedical Devices Developed
3. Antiviral Coating On Bank Notes, Photocopiers Could Help Check Epidemics
4. Edible Food Coating Kills Bacteria And Adds Flavor
5. Drug Eluting Nanostructured Coatings Enable Targeted Drug Therapy for Orthopedic Patients
6. Analyzing The Side Effects Of Sirolimus Stents
7. Stronger Backing for Drug-Coated Stents
8. Drug-Coated Stents – Proven to be More Effectiv
9. The Efficacy Of Newer Stents Questioned
10. Expandable metal stents used in digestive cancers
11. Stents That Release Medication To Check Artery Narrowing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... December 03, 2016 , ... The Lymphoma Research Foundation (LRF) ... and serving the lymphoma community through a comprehensive series of education programs, outreach ... in New York City, with long-time partners The Paul Foundation, on November 10, ...
(Date:12/4/2016)... ... December 03, 2016 , ... Penrose Senior Care Auditors® was ... Tuesday evening at the 26th Annual SMU Cox Dallas 100™ Awards Ceremony and ... Institute for Entrepreneurship. Dallas 100™, co-founded by the Caruth Institute, honors the ingenuity, ...
(Date:12/4/2016)... ... December 04, 2016 , ... Responsible dental care hinges on regular brushing ... achieve optimal results. This important necessity inspired an inventor from Las Vegas, Nev., to ... ensure that people break or avoid bad techniques of brushing the teeth in order ...
(Date:12/2/2016)... ... December 02, 2016 , ... On Dec. 2, 2016, CURE® magazine ... San Diego honoring the 2016 MPN Heroes—eight individuals who have made a difference in ... and beyond the standard of care, demonstrating leadership within the MPN community and/or a ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... announces the launch of its 60-day free trial program for all of the ... make the offer a truly hassle free experience. , FlexiSpot’s unique desktop risers ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... highly innovative, personalized cell-based treatment for a high-risk form of the most ... Children,s Hospital of Philadelphia today reported new results ... The physician-scientists presented findings at the annual meeting of the ... Continue Reading ... ...
(Date:12/2/2016)... 2, 2016 bioLytical Laboratories, un líder mundial en test ... INSTI HIV Self Test , a los miembros de la Kenya Pharmaceutical Association. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por ...
(Date:12/2/2016)... , Dec 2, 2016 Research and Markets ... Share, Development, Growth and Demand Forecast to 2022" report to their ... , , ... $6 billion in 2015, and it is expected to grow at a ... is expected to witness faster growth during the forecast period, a CAGR ...
Breaking Medicine Technology: