Navigation Links
Nanowire coating for bone implants, stents
Date:8/27/2007

FAYETTEVILLE, Ark. - University of Arkansas researchers have found a simple, inexpensive way to create a nanowire coating on the surface of biocompatible titanium that can be used to create more effective surfaces for hip replacement, dental reconstruction and vascular stenting. Further, the material can easily be sterilized using ultraviolet light and water or using ethanol, making it useful in hospital settings and meat-processing plants

Wenjun Dong, Tierui Zhang, Lisa Cooney, Hong Wang, Yanbin Li, Andrew Cogbill, Vijay Varadan and Z. Ryan Tian of the University of Arkansas, Ying-Bing Jiang of the University of New Mexico, and Joshua Epstein of the University of Arkansas for Medical Sciences report their findings in an upcoming issue of the journal Chemistry of Materials.

The researchers used an alkali and heat to create titanium oxide-based ceramic nanowires that coat the surface of a titanium medical device.

"We can control the length, the height, the pore openings and the pore volumes within the nanowire scaffolds" by varying the time, temperature and alkali concentration in the reaction, said Z. Ryan Tian, assistant professor of chemistry and biochemistry in the J. William Fulbright College of Arts and Sciences. "This process is also extremely sustainable," requiring only that the device be rinsed in reusable water after the heating process.

Reconstructive bone surgeries, such as hip replacements, use titanium implants. However, muscle tissue may not adhere well to titanium's smooth surface, causing the implant to fail after a decade or so and requiring the patient to undergo a second surgery.

Tian and his colleagues created a nanowire-coated joint and placed it in mice. After four weeks, the researchers found that tissue had adhered to the joint.

"We saw beautiful tissue growth - lots of muscle fibers," Tian said. "We've added one more function to the currently-in-use titanium implant."

Because the researchers can control the size and shape of the pores in the nanowire scaffold, the material also could be coated onto stents used in patients with coronary artery disease and in potential stroke victims. Conventional stents sometimes become reclogged with fat after implantation. The most recent stent used to address this problem, called the drug-eluting stent, consists of a polymer coating mixed with the drugs, but the coating may be vulnerable to biodegradation, and may not function for long. The nanowire coating without the degradation problem could be used to carry drugs that would help keep the arteries clear over a long period of time.

"This drug release could be applied to the angioplasty catheter's surface," Tian said.

In addition to these biomedical applications, the nanofiber scaffold has a property that may make it useful in both hospitals and food processing plants: The material, when rinsed in water and exposed to ultraviolet light, kills more than 99 percent of bacteria on its surface. This effect occurs because photons from the light cause a charge separation on the material, splitting water molecules into free radicals that destroy the bacteria. Alternatively, immersion in 70 percent ethanol completely sterilizes the material, allowing growth of cells/tissues in the laboratory prior to implantation.

This property could prove extremely useful in bacteria-prone environments, performing such functions as sterilizing on-site surgery hospitals used during military actions or cleaning surfaces in meat-processing plants.

"You could just use water to rinse and UV light to sterilize surfaces," Tian said.

The researchers have applied for a provisional patent for the multifunctional nanowire bioscaffolds on titanium or titanium-containing alloys such as Nitinol.


'/>"/>
Contact: Melissa Lutz Blouin
blouin@uark.edu
479-575-5555
American Chemical Society
Source:Eurekalert

Related medicine news :

1. Aloe Vera Coating For Fruits And Vegetables Preservation
2. Anti-Microbial Coating For Use Over Biomedical Devices Developed
3. Antiviral Coating On Bank Notes, Photocopiers Could Help Check Epidemics
4. Edible Food Coating Kills Bacteria And Adds Flavor
5. Drug Eluting Nanostructured Coatings Enable Targeted Drug Therapy for Orthopedic Patients
6. Analyzing The Side Effects Of Sirolimus Stents
7. Stronger Backing for Drug-Coated Stents
8. Drug-Coated Stents – Proven to be More Effectiv
9. The Efficacy Of Newer Stents Questioned
10. Expandable metal stents used in digestive cancers
11. Stents That Release Medication To Check Artery Narrowing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
Breaking Medicine Technology: