Navigation Links
Nanotech researchers' 2-step method shows promise in fighting pancreatic cancer

Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a new technique for fighting deadly and hard-to-treat pancreatic cancer that uses two different types of nanoparticles, the first type clearing a path into tumor cells for the second, which delivers chemotherapy drugs.

The research team, led by Dr. Andre Nel, a UCLA professor of nanomedicine and a member of the California NanoSystems Institute at UCLA, and Dr. Huan Meng, a UCLA adjunct assistant professor of nanomedicine, has shown that this new drug-delivery technique is effective in treating pancreatic cancer in a mouse model.

The results of the study are published online in the journal ACS Nano and will be featured in the November 2013 print issue.

Pancreatic ductal adenocarcinoma, or pancreatic cancer, is a deadly disease that is nearly impossible to detect until it is in the advanced stage. Treatment options are limited and have low success rates. The need for innovative and improved treatment of pancreatic cancer cannot be overstated, the researchers said, as a pancreatic cancer diagnosis has often been synonymous with a death sentence.

Pancreatic ductal adenocarcinoma tumors are made up of cancer cells that are surrounded by other structural elements called stroma. The stroma can be made of many substances, including connective tissue and pericyte cells, which block standard chemotherapy drugs in tumor blood vessels from efficiently reaching the cancer cells, reducing the effectiveness of treatment.

The dual-wave nanotherapy method employed by Nel and Meng uses two different kinds of nanoparticles injected intravenously in a rapid succession. The first wave of nanoparticles carries a substance that removes the pericytes' vascular gates, opening up access to the pancreatic cancer cells; the second wave carries the chemotherapy drug that kills the cancer cells.

Nel and Meng, along with colleagues Dr. Jeffrey Zink, a UCLA professor of chemistry and biochemistry, and Dr. Jeffrey Brinker, a University of New Mexico professor of chemical and nuclear engineering, sought to place chemotherapy drugs into nanoparticles that could more directly target pancreatic cancer cells, but they first needed to find a way to get those nanoparticles through the sites of vascular obstruction caused by pericytes, which restrict access to the cancer cells.

Through experimentation, they discovered they could interfere with a cellular signaling pathway the communication mechanism between cells that governs the pericytes' attraction to the tumor blood vessels. By creating nanoparticles that effectively bind a high load of the signaling pathway inhibitor, the researchers were able to develop a first wave of nanoparticles that would separate the pericytes from the endothelial cells on the blood vessel. This would open the vascular gate for the next wave of nanoparticles, which carry the chemotherapeutic agent to the cancer cells inside the tumor.

To test this nanotherapy, the researchers used immuno-compromised mice in which they grew human pancreatic tumors called xenografts under the skin. With the two-wave method, the xenograft tumors had a significantly higher rate of shrinkage than tumors exposed only to chemotherapy given as a free drug or carried in nanoparticles without first-wave treatment.

"This two-wave nanotherapy is an existing example of how we seek to improve the delivery of chemotherapy drugs to their intended targets using nanotechnology to provide an engineered approach," said Nel, chief of UCLA's division of nanomedicine. "It shows how the physical and chemical principles of nanotechnology can be integrated with the biological sciences to help cancer patients by increasing the effectiveness of chemotherapy while also reducing side effects and toxicity. This two-wave treatment approach can also address biological impediments in nanotherapies for other types of cancer."


Contact: Shaun Mason
University of California - Los Angeles

Related medicine news :

1. Giving transplanted cells a nanotech checkup
2. Furnace Accelerator Startup SiO2 Nanotech Develops Anti-Fogging Technology for Variety of Applications
3. Outlook with Ben Kingsley Exploring Role of Nanotechnology in Medicine for Upcoming Report
4. Nanotech system, cellular heating may improve treatment of ovarian cancer
5. CWRU researchers aim nanotechnology at micrometastases
6. NIH awards $20 million over 5 years to train next generation of global health researchers
7. Researchers develop a new cell and animal model of inflammatory breast cancer
8. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
9. Researchers Find Gene Mutations That May Be a Key to Autism
10. Researchers find evidence of banned antibiotics in poultry products
11. NJ stroke researchers report advances in spatial neglect research at AAN Conference
Post Your Comments:
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... “While riding ... an inventor, from Bronx, N.Y. “I thought there had to be a convenient and ... the PROTECTOR. , The PROTECTOR enables disabled individuals to safely travel during cold or ...
(Date:11/25/2015)... ... November 25, 2015 , ... "When I underwent ... bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In order to ... the patent-pending RECOVERY BRA for added comfort and support. The bra is easier ...
(Date:11/25/2015)... ... November 25, 2015 , ... Bcureful—a ... (TSC), as well as raising public awareness of the disorder while helping to ... third donation of $35,000 to bolster progress at the Tuberous Sclerosis Complex Center ...
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic Software helps practice ... an agreement between the practice owner and the patient that automatically manages all ... projections. Click here to learn more. , According to ...
(Date:11/24/2015)... ... November 24, 2015 , ... Young patients with a wide variety of dental ... Dr. Kedar S. Lele, who are pediatric dentists in Tucson, AZ . Unlike ... iPlus 2.0™ system causes minimal discomfort and bleeding to the patient during treatment and ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , November 24, 2015 ... --> adds Latest Guidebook for ... of 217 pages published in November 2015 to ... online business intelligence library at . ... of the fastest growing global economies with a ...
(Date:11/24/2015)... 24, 2015  Ascendant Solutions, Inc. (Pink Sheets: ASDS ... of Directors has declared a special 1 percent stock dividend ... payable December 14, 2015, to shareholders of record December 7, ... additional shares of common stock. --> ... a strong endorsement of our confidence in Ascendant,s growth strategy ...
(Date:11/24/2015)... Nov. 24, 2015 Diplomat Pharmacy, Inc. (NYSE: DPLO) ... of Clinical Services, Education and Human Resources will be presenting ... Oncology Drugs: Health Plan Strategies for a Dynamic Market" on ... Fenrick , a consultant with the Cambridge Advisory Group, where ... The webinar will discuss the rapid growth ...
Breaking Medicine Technology: