Navigation Links
Nanosponge drug delivery system more effective than direct injection
Date:6/2/2010

" says Harth. The backbone is a long length of polyester. It is mixed in solution with small molecules called cross-linkers that act like tiny grappling hooks to fasten different parts of the polymer together. The net effect is to form spherically shaped particles filled with cavities where drug molecules can be stored. The polyester is biodegradable, so it breaks down gradually in the body. As it does, it releases the drug it is carrying in a predictable fashion.

"Predictable release is one of the major advantages of this system compared to other nanoparticle delivery systems under development," says Harth. When they reach their target, many other systems unload most of their drug in a rapid and uncontrollable fashion. This is called the burst effect and makes it difficult to determine effective dosage levels.

Another major advantage is that the nanosponge particles are soluble in water. Encapsulating the anti-cancer drug in the nanosponge allows the use of hydrophobic drugs that do not dissolve readily in water. Currently, these drugs must be mixed with another chemical, called an adjuvant reagent, that reduces the efficacy of the drug and can have adverse side-effects.

It is also possible to control the size of nanosponge particles. By varying the proportion of cross-linker to polymer, the nanosponge particles can be made larger or smaller. This is important because research has shown that drug delivery systems work best when they are smaller than 100 nanometers, about the depth of the pits on the surface of a compact disc. The nanosponge particles used in the current study were 50 nanometers in size. "The relationship between particle size and the effectiveness of these drug delivery systems is the subject of active investigation," says Harth.

The other major advantage of Harth's system is the simple chemistry required. The researchers have developed simple, high-yield "click chemistry" methods for making the nanosponge pa
'/>"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. A New Firefox Add-on Revolutionizes the Delivery of Discounts for Online Shoppers
2. Drug now used to treat erectile dysfuncton may enhance delivery of herceptin to certain brain tumors
3. FreshDirect Celebrates Nurse Appreciation Week with Delivery of Complimentary 4-Minute Meals for Nurses at Hospitals in Westchester and Greenwich, CT
4. New Nasal Drug Delivery Device for Chronic Sinusitis Patients Now Available from ASL Pharmacy
5. Magnetic Fields Concentrate Drug Delivery
6. Panel questions VBAC bans, advocates expanded delivery options for women
7. Electronic Health Information Leader Says Physician Practice Redesign is Vital Next Step Towards Safer, More Effective Care Delivery
8. Targeted delivery of losartan reduces liver inflammation and scarring
9. Gourmet Diet Delivery Unites with First Lady's Battle Against Obesity The Fresh Diet Begins Delivering Meals to DC
10. GE Healthcare, Intel and Mayo Clinic explore new models of health care delivery
11. Launch of On Time Air Filters: Home Air Filter Delivery Service Helps Homeowners Replace All-Important Home HVAC Filters On Time
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanosponge drug delivery system more effective than direct injection
(Date:12/20/2014)... 20, 2014 The Doctor’s Office Urgent Care ... better part of a decade. They’ve treated over 40,000 ... faster healthcare alternative to the Paramus area. ... new additions to their staff of top-notch board certified physicians: ... MD. These new doctors will work tirelessly to ...
(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer ... coming Christmas. In the promotion, all buyers worldwide can ... have something special for the women who are looking ... our new collections of 2015 dresses have been unveiled ... greatly discounted prices. Visit our website now before they ...
(Date:12/20/2014)... Today, Balfleet.com, one of the most outstanding dressmakers ... off on its Mother of the Bride Dresses ... the bride dresses from Balfleet.com feature gorgeous looks and ... takes pride in providing high quality dresses to its ... discounts on our mother of the bride dresses, and ...
(Date:12/19/2014)... Energy Textiles is excited to ... Celliant, the world’s leading responsive textile, can now ... There are a number of benefits to wearing ... and balanced body temperature; which can lead to ... enhanced athletic performance; and overall wellness. In addition, ...
(Date:12/19/2014)... 20, 2014 These vanadium reserves are ... nations. Around 151,000 tons of vanadium were produced globally ... vanadium usage increased at 6.7% AAGR during the period ... iron industry, being the largest consumer, accounted for more ... by titanium-vanadium alloy and the chemical industry. , View ...
Breaking Medicine News(10 mins):Health News:The Doctor's Office Urgent Care Adds 3 New Physicians to Their Growing Medical Team 2Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2Health News:Energy Textiles Launches Celliant Revitalizing Bedsheets 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3
... not to cut out good prenatal care Prenatal physical ... in the long runLOS ANGELES, March 18 * ... the benefits of regular exercise during pregnancy and in ... vs. traditional exercise at the gym or running, can ...
... Growth Highlighted with Signing of 1,000th CustomerCARROLLTON, ... leading provider of integrated electronic health records ... announced Cardiovascular Specialty Services of North Texas ... 2008, Greenway,s CCHIT Certified(R) 08 EHR product ...
... March 18 April is Autism Awareness Month and ... announced today the creation of Kids, Brain Trust, a ... cranial osteopathy, a clinically validated specialty. KBT will provide ... to middle-income households. Enrollment is anticipated to begin in ...
... provided by InfantSEE(R) ProgramDES MOINES, Iowa, March 18 ... with eye and vision problems across the United ... devoting appointments to no-cost, comprehensive eye and vision ... of age through InfantSEE(R). InfantSEE(R), a public health ...
... SmoothShapes(R) System in DenverMERRIMACK, N.H., March 18 ... on body shaping, announced today that Refresh Laser Spa, ... center in Denver to offer the SmoothShapes(R) system for ... at an open house at Refresh Laser Spa (6300 ...
... X-ray-guided spinal tap procedure fails more than half of the ... at all, for those patients, according to a new study ... , The study also shows that the X-ray-guided form of ... risk of bleeding for patients older than 80 compared to ...
Cached Medicine News:Health News:Proactive, Low-Cost Prenatal Physical Therapy Reduces Pregnancy Complications, Eases Labor and Delivery and Shortens Recovery Time for Mothers 2Health News:Proactive, Low-Cost Prenatal Physical Therapy Reduces Pregnancy Complications, Eases Labor and Delivery and Shortens Recovery Time for Mothers 3Health News:Proactive, Low-Cost Prenatal Physical Therapy Reduces Pregnancy Complications, Eases Labor and Delivery and Shortens Recovery Time for Mothers 4Health News:Greenway Medical Technologies Continues Fast-Paced Growth With Addition of Cardiovascular Specialty Associates of North Texas (CSANT) 2Health News:Greenway Medical Technologies Continues Fast-Paced Growth With Addition of Cardiovascular Specialty Associates of North Texas (CSANT) 3Health News:Kids' Brain Trust: A New Nonprofit Gives Parents Hope of Defeating Autism 2Health News:Des Moines-Area Optometrists Partner With Sens. Harkin and Grassley; U.S. House Leaders in Improving Infant Eye and Vision Care 2Health News:Des Moines-Area Optometrists Partner With Sens. Harkin and Grassley; U.S. House Leaders in Improving Infant Eye and Vision Care 3Health News:Des Moines-Area Optometrists Partner With Sens. Harkin and Grassley; U.S. House Leaders in Improving Infant Eye and Vision Care 4Health News:Des Moines-Area Optometrists Partner With Sens. Harkin and Grassley; U.S. House Leaders in Improving Infant Eye and Vision Care 5Health News:New Anti-Cellulite Treatment Prepares Women for Warmer Weather and Beyond 2Health News:New Anti-Cellulite Treatment Prepares Women for Warmer Weather and Beyond 3Health News:Spinal taps carry higher risks for infants and elderly, study shows 2Health News:Spinal taps carry higher risks for infants and elderly, study shows 3
(Date:12/17/2014)... 17, 2014  Northstar Global Business Services, Inc. ... (DTC) has made their final decision and has ... Company,s stock effective December 15, 2014, and has ... depository and book entry transfer services. All deposit restrictions ... once again fully "DTC Eligible", and has resumed ...
(Date:12/17/2014)... 17, 2014 , ... a hub of information concerning the biopharmaceutical Group,s national and ... further addition to the recently launched institutional website that is ... been enriched by a new chapter in the fascinating story ... richly detailed and panoramic hub on the world of clinical ...
(Date:12/17/2014)... 17, 2014  RXi Pharmaceuticals Corporation (NASDAQ: ... discovering, developing and commercializing innovative therapies addressing major ... of enrollment in its first Phase 2a study, ... confirmed the 1-month findings that were reported in ... - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , , ...
Breaking Medicine Technology:Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5
... IDAHO FALLS, Idaho, Dec. 12, 2011 International Isotopes ... a conference call to give an update of the ... performance of its core business segments as well as ... depleted uranium de-conversion project.What:  , International Isotopes Inc. General ...
... of Eli Lilly and Company (NYSE: LLY ) ... December 12, 2011. Baicker, 40, is Professor of Health Economics ... Harvard School of Public Health. She is also a research ... elected member of the Institute of Medicine. As a member of ...
Cached Medicine Technology:International Isotopes Inc. Announces Conference Call to Give an Update on the Company's General Business Status 2Katherine Baicker Elected to Lilly Board of Directors 2
... path that allows users to take full ... potential to combine two units offers fully ... stimulating coil. The ability to change pulse ... level of each Magstim 200 allows for ...
... is a surgical approach to glaucoma management ... application. The ciliary body (which produces aqueous ... the anterior or posterior segment, through the ... are easily and accurately identified utilizing endoscopy. ...
... surgical approach to glaucoma management that employs ... ciliary body (which produces aqueous humour) is ... or posterior segment, through the endoscope in ... and accurately identified utilizing endoscopy. This allows ...
... of German Craftsmanship have produced ... the world. Ocutek® now makes ... holders of the coveted Meisterbrief ... apprenticeship, are qualified to become ...
Medicine Products: