Navigation Links
Nanoshell shields foreign enzymes used to starve cancer cells from immune system
Date:6/17/2014

Nanoengineers at the University of California, San Diego have developed a nanoshell to protect foreign enzymes used to starve cancer cells as part of chemotherapy. Their work is featured on the June 2014 cover of the journal Nano Letters.

Enzymes are naturally smart machines that are responsible for many complex functions and chemical reactions in biology. However, despite their huge potential, their use in medicine has been limited by the immune system, which is designed to attack foreign intruders. For example, doctors have long relied on an enzyme called asparaginase to starve cancer cells as a patient undergoes chemotherapy. But because asparaginase is derived from a nonhuman organism, E. Coli, it is quickly neutralized by the patient's immune system and sometimes produces an allergic reaction. In animal studies with asparaginase, and other therapeutic enzymes, the research team found that their porous hollow nanoshell effectively shielded enzymes from the immune system, giving them time to work.

Asparaginase works by reacting with amino acids that are an essential nutrient for cancer cells. The reaction depletes the amino acid, depriving the abnormal cells from the nutrients they need to proliferate.

"Ours is a pure engineering solution to a medical problem," said Inanc Ortac (Ph.D. '13), who developed the technology as part of his doctoral research in the laboratory of nanoengineering professor Sadik Esener at UC San Diego Jacobs School of Engineering.

The nanoshell acts like a filter in the bloodstream. The enzymes are loaded into the nanoparticle very efficiently through pores on its surface and later encapsulated with a shell of nanoporous silica. The shell's pores are too small for the enzyme to escape but big enough for diffusion of amino acids that feed cancer cells in and out of the particle. The enzymes remain trapped inside where they deplete any amino acids that enter.

"This is a platform technology that may find applications in many different fields. Our starting point was solving a problem for cancer therapeutics," said Ortac.


'/>"/>
Contact: Catherine Hockmuth
chockmuth@ucsd.edu
858-822-1359
University of California - San Diego
Source:Eurekalert  

Related medicine news :

1. RF Safe Cell Phone Radiation Shields Prevent Fetal Radiation Exposure
2. Health reform shields young adults from emergency medical costs, study finds
3. Exercise shields children from stress
4. Dartmouth study provides first global evidence that foreign aid boosts public opinion
5. UTA professors new book explores international response time to foreign conflicts
6. Foreign-educated health workers play vital role in US health system
7. Foreign private patients provide a lucrative source of NHS income
8. Foreign Funded Enterprises Lead China Dialysis Industry 2017 Forecasts in New Research Report at RnRMarketResearch.com
9. Foreign Bank Account Owners to Report Financial Account & Assets by June 28th for 2012 or File a FBAR Amnesty to Avoid IRS Financial and Criminal Penalties
10. ‘A Foreign Nurse’s Guide To America’ Helps Nurses Looking To Relocate
11. Scott Sheldon LLC Taps into Foreign-Trade Zone Value for Supply Chain, Partners with Foreign-Trade Zone Corporation (FTZ Corp)
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoshell shields foreign enzymes used to starve cancer cells from immune system
(Date:5/6/2016)... ... May 06, 2016 , ... Fat-Freezing, which ... around the body, is the most popular among body sculpting options, according to ... sense to cosmetic surgeon Dr. Richard Buckley, medical director of MilfordMD Cosmetic Dermatology ...
(Date:5/6/2016)... ... May 06, 2016 , ... From the Speaker Podium to the Exhibit ... share its insights on managing Customers Engagement at SpeechTek 2016 Event, taking place May ... will deliver a Presentation on “5 Customer Engagement Strategies to improve Customer ...
(Date:5/6/2016)... ... 06, 2016 , ... Multiple award winning plumbing company in San ... years. Maintaining core values of exceptional customer service, quality work at reasonable rates, and ... name in San Diego plumbing, and other services including heating & air conditioning and ...
(Date:5/6/2016)... OR (PRWEB) , ... May 06, 2016 , ... This ... but for women everywhere. The 17th annual National Women’s Health Week takes ... Office on Women’s Health are combining forces to empower women to make their health ...
(Date:5/5/2016)... ... May 05, 2016 , ... TransWipe Volume 3 is a set of 30 ... a TransWipe preset between two video clips to instantly add a unique transition to ... with customizable color and orientation options. TransWipe Volume 3 is a Final Cut Pro ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016  As a teenager, ... contracted rheumatic fever, which damaged his heart. He continued ... But by June 2013, Shepherd,s heart was giving out ... death. On June 20, 2013, the Mesa, ... Artificial Heart (TAH-t). Like a heart transplant, the SynCardia ...
(Date:5/3/2016)... May 3, 2016   BIOTRONIK , a ... announced Food and Drug Administration (FDA) approval of ... provides heart failure patients with access to diagnostic ... have remote monitoring with daily automatic transmission and ... rate in response to physiological demands. ...
(Date:5/3/2016)... 3, 2016   BIOTRONIK will be exhibiting ... beyond the implant at the Heart Rhythm Society,s 37 ... San Francisco . "Physicians ... quality of patient care and satisfaction possible. Part of ... and every tomorrow," said Marlou Janssen , President, ...
Breaking Medicine Technology: