Navigation Links
Nanoshell shields foreign enzymes used to starve cancer cells from immune system
Date:6/17/2014

Nanoengineers at the University of California, San Diego have developed a nanoshell to protect foreign enzymes used to starve cancer cells as part of chemotherapy. Their work is featured on the June 2014 cover of the journal Nano Letters.

Enzymes are naturally smart machines that are responsible for many complex functions and chemical reactions in biology. However, despite their huge potential, their use in medicine has been limited by the immune system, which is designed to attack foreign intruders. For example, doctors have long relied on an enzyme called asparaginase to starve cancer cells as a patient undergoes chemotherapy. But because asparaginase is derived from a nonhuman organism, E. Coli, it is quickly neutralized by the patient's immune system and sometimes produces an allergic reaction. In animal studies with asparaginase, and other therapeutic enzymes, the research team found that their porous hollow nanoshell effectively shielded enzymes from the immune system, giving them time to work.

Asparaginase works by reacting with amino acids that are an essential nutrient for cancer cells. The reaction depletes the amino acid, depriving the abnormal cells from the nutrients they need to proliferate.

"Ours is a pure engineering solution to a medical problem," said Inanc Ortac (Ph.D. '13), who developed the technology as part of his doctoral research in the laboratory of nanoengineering professor Sadik Esener at UC San Diego Jacobs School of Engineering.

The nanoshell acts like a filter in the bloodstream. The enzymes are loaded into the nanoparticle very efficiently through pores on its surface and later encapsulated with a shell of nanoporous silica. The shell's pores are too small for the enzyme to escape but big enough for diffusion of amino acids that feed cancer cells in and out of the particle. The enzymes remain trapped inside where they deplete any amino acids that enter.

"This is a platform technology that may find applications in many different fields. Our starting point was solving a problem for cancer therapeutics," said Ortac.


'/>"/>
Contact: Catherine Hockmuth
chockmuth@ucsd.edu
858-822-1359
University of California - San Diego
Source:Eurekalert  

Related medicine news :

1. RF Safe Cell Phone Radiation Shields Prevent Fetal Radiation Exposure
2. Health reform shields young adults from emergency medical costs, study finds
3. Exercise shields children from stress
4. Dartmouth study provides first global evidence that foreign aid boosts public opinion
5. UTA professors new book explores international response time to foreign conflicts
6. Foreign-educated health workers play vital role in US health system
7. Foreign private patients provide a lucrative source of NHS income
8. Foreign Funded Enterprises Lead China Dialysis Industry 2017 Forecasts in New Research Report at RnRMarketResearch.com
9. Foreign Bank Account Owners to Report Financial Account & Assets by June 28th for 2012 or File a FBAR Amnesty to Avoid IRS Financial and Criminal Penalties
10. ‘A Foreign Nurse’s Guide To America’ Helps Nurses Looking To Relocate
11. Scott Sheldon LLC Taps into Foreign-Trade Zone Value for Supply Chain, Partners with Foreign-Trade Zone Corporation (FTZ Corp)
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoshell shields foreign enzymes used to starve cancer cells from immune system
(Date:2/10/2016)... ... 2016 , ... LaserShip, a regional parcel carrier that services the eastern U.S., ... last Friday in order to aid in the Flint water crisis. In 2014, LaserShip ... located in Clio, only 15 miles away from Flint. , “We have deep roots ...
(Date:2/10/2016)... ... February 10, 2016 , ... As part of its ongoing ... February 2016. Each webinar features a dynamic expert and thoughtful presentation to give ... patients and facilities. Both events are free to attend, but registration is ...
(Date:2/10/2016)... ... 10, 2016 , ... The Wickman Agency in Garland, TX ... local community. Pledging to select a new beneficiary every 60 days, the agency ... goal is to bring community awareness to important local causes by forming campaigns ...
(Date:2/10/2016)... ... ... Dr. Jessica Barron, of Barron Family Dental in Thornton, Colorado , is ... the North Metro Denver area. The new dental practice focuses on comfort where patients ... the most relaxing environment. , While some dental visits can create anxiety for patients, ...
(Date:2/10/2016)... ... ... Gout is like no other joint pain. It strikes suddenly, like flicking on ... redness. It is triggered by the crystallization of uric acid within the joints. It ... to the February 2016 issue of Harvard Men's Health Watch. , The large joint ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Inc. (Vanda) (NASDAQ: VNDA ), today announced financial ... year ended December 31, 2015. --> ... for Vanda with the continued growth of HETLIOZ in ... for Non-24," said Mihael H. Polymeropoulos, M.D., Vanda,s President ... product portfolio builds on this success and underscores Vanda,s ...
(Date:2/10/2016)... --> --> This press release is intended for U.S. ... Japan .  --> A separate press release has been prepared for ... continues to strengthen its presence in ... continues to strengthen its presence in Japan ... to strengthen its presence in Japan ...
(Date:2/10/2016)... A new report from business intelligence provider GBI Research - Alzheimer,s ... will more than double from just under $5 billion in 2014 to an ... 11%. Canada , France , ... , the UK, and Japan , and will primarily be ... Canada , France , Germany , ...
Breaking Medicine Technology: