Navigation Links
Nanoscale gene 'ignition switch' may help spot and treat cancer
Date:12/15/2010

In a proof of principal study in mice, scientists at Johns Hopkins and the Virginia Commonwealth University (VCU) have shown that a set of genetic instructions encased in a nanoparticle can be used as an "ignition switch" to rev up gene activity that aids cancer detection and treatment.

The switch, called a promoter, is a set of chemical letters that interacts with DNA to turn on gene activity. In this case, the scientists used a promoter called PEG-Prom, cloned by VCU researcher Paul Fisher, Ph.D. PEG-Prom is activated only when inside cancer cells, not in normal ones.

"With current imaging devices like CT and PET, we can tell if something is wrong in a patient, but we don't have definitive tools to distinguish cancer from inflammation or infection," says Martin Pomper, M.D., Ph.D., professor of radiology at Johns Hopkins. "It generally takes at least one month after giving patients certain cancer treatments before existing imaging tools can measure the patient's response to the therapy."

To differentiate cancer cells from normal cells, Johns Hopkins scientists connected PEG-Prom to either a gene that produces firefly luciferase, the substance that make fireflies glow, or a gene called HSV1tk, which initiates a chemical reaction with radioactive labels inside the cell that can be detected by imaging devices. Once inside a cancer cell, the PEG-Prom switch is turned on, and it activates either the luciferase or HSV1tk gene.

Then, they stuffed the PEG-Prom/gene combination into tiny spheres about 50,000 times smaller than the head of a pin and intravenously injected the nanoparticles into mice with either metastatic breast cancer or melanoma.

The findings, reported in the December 12 online edition of Nature Medicine, reveal a 30-fold difference in identifying cancer cells containing luciferase and normal cells that did not contain the substance. Similar results were observed in cancer cells filled with
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nanoscale stealth probe slides into cell walls seamlessly, say Stanford engineers
2. Cochlear Appoints Switched on Media to Develop its SEO Across the Asia Pacific Region
3. Researchers create drug to keep tumor growth switched off
4. BCS Global Launches PSVN (Public Switched Video Network), an Initiative to Provide a Framework for Inter-Connecting Business to Business Video Networks
5. Daylight-Saving Time Switch May Leave You Sleepy, U-M Physician Says
6. Researchers discover brain tumors grow-or-go switch
7. Discovery of cellular switch may provide new means of triggering cell death, treating disease
8. UBC graduate student finds a start/stop switch for retroviruses
9. Brains master switch is verified by Iowa State University researcher
10. Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists
11. Memorys master switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... 2015 On April 8th, 2015, Choices ... at the world famous Avalon Hollywood. Organized by Debbie ... in TV and film, the EcoLuxe Lounge is a ... awards ceremonies and festivals throughout the year. A gathering ... and socially conscious products and services, this daylong event ...
(Date:4/21/2015)... Colmar, PA (PRWEB) April 21, 2015 ... Ichthyosis & Related Skin Types, Inc.® (FIRST) will publish ... ichthyosis. The campaign will run throughout the month of ... Voice. It Matters to Someone." The positioning was ... about this rare skin disorder and to help support ...
(Date:4/21/2015)... 21, 2015 Approximately 75 million Americans ... U.S. Environmental Protection Agency (EPA). On top of this, ... smoke increase the level of toxins found in the ... these harmful toxins is to increase consumption of broccoli. ... highest level of glucoraphanin – a long-lasting antioxidant – ...
(Date:4/21/2015)... 21, 2015 As a provider of ... found that their rehabilitation strategy, which involves various treatment ... relapses. In an effort to offer hope and encouragement ... their lives, Best Drug Rehabilitation has featured a series ... many successful graduates of their recovery program. , ...
(Date:4/21/2015)... Zane Benefits, the leader in individual ... publication of a new guide “Health Reimbursement Accounts in ... the health insurance industry, including how employers can use ... what is permitted when implementing an HRA. This simple, ... which HRAs are compliant this year. , According ...
Breaking Medicine News(10 mins):Health News:Hollywood's Santana Dempsey and Choices Recovery South Bend Examine Victory over Personal Struggles 2Health News:May is Ichthyosis Awareness Month. Use Your Voice. 2Health News:New Survey Shows Americans Are Cooking the Health Out of Broccoli 2Health News:New Survey Shows Americans Are Cooking the Health Out of Broccoli 3Health News:Best Drug Rehabilitation Graduate Discusses Making Amends and Rebuilding Relationships 2
... Inc. and TPABenefits, Inc.,of San Antonio, TX announced ... INETICO system and the TPABenefits Web Portal. This ... Pre-Certification,and Wellness data source and allows Payors, TPA,s, ... Case Notes on the,TPABenefits Web Portal., The ...
... Calif., May 8 IRIDEX,Corporation (Nasdaq: IRIX ) ... financial results after the market closes on Tuesday, May ... host a conference,call with the investment community at 5:00 ... the results of the quarter and other business,developments., ...
... Viruses are masters of deception, duping their host,s cells ... has found that human cytomegalovirus (HCMV) can mimic a ... disrupting a cell,s primary anti-cancer mechanism. , Writing in ... University of Wisconsin-Madison and Harvard Medical School report that ...
... disease, osteoarthritis (OA) is the leading cause of disability in ... OA most often strikes the knee, particularly the inner aspect ... this vulnerable joint compartment is the knee adduction moment, an ... increase in the peak knee adduction moment is associated with ...
... More than 8,700 babies born each year in Washington to ... is,one of the best things a woman can do to ... time for Mother,s Day on May 11, the state,Department of ... Line,to provide pregnant women with more help when they,re ready ...
... MADISON, Wis., May 8 Let,s face it,Americans ... prove,positive, like when it promotes greater awareness and ... of cancer, lung cancer,causes almost twice as many ... today launched a national, multi-media public service,announcement (PSA) ...
Cached Medicine News:Health News:INETICO, Inc. Creates Data Interface with TPABenefits, Inc. Offering a Powerful Care and Claims Management Solution 2Health News:Virus mimics human protein to hijack cell division machinery 2Health News:Cane use may reduce risk of knee osteoarthritis progression 2Health News:Cane use may reduce risk of knee osteoarthritis progression 3Health News:Tobacco Quit Line Expands Services for Pregnant Women Who Smoke 2Health News:National Lung Cancer Partnership Launches Campaign to Raise Lung Cancer Awareness Among Women 2
(Date:4/21/2015)... 2015 Gary A. Puckrein , PhD, ... Forum (NMQF), today will present an award to ... Research and Manufacturers of America (PhRMA), for his ... behalf of PhRMA, and in conjunction with NMQF, Castellani ... awareness, start conversations, and increase diversity in clinical trials, ...
(Date:4/21/2015)... -- The North American dermatology diagnostic devices market is ... 2014 to 2019. Although mature markets (the U.S. and ... the dermatology diagnostic devices market, Mexico ... of 9.8% during the forecast period. The growth of ... such as rising incidences of skin disorders, increasing demand ...
(Date:4/21/2015)... April 21, 2015 Softheon, Inc., ... integration and business operation, has confirmed its status ... Centers of Medicare & Medicaid Services (CMS).  Under ... with access to the Federal Data Hub to ... into qualified health insurance plans. ...
Breaking Medicine Technology:National Minority Quality Forum to Award PhRMA President John Castellani for Leadership in Increasing Clinical Trial Diversity 2National Minority Quality Forum to Award PhRMA President John Castellani for Leadership in Increasing Clinical Trial Diversity 3North American Dermatology Diagnostic Devices Market by Diagnostic Device, by Treatment Device, by Application - Forecast to 2019 2North American Dermatology Diagnostic Devices Market by Diagnostic Device, by Treatment Device, by Application - Forecast to 2019 3Softheon Confirms Web Broker Entity (WBE) Status with the Centers of Medicare & Medicaid Services (CMS) 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: