Navigation Links
Nanoparticles help Mayo Clinic researcher deliver steroids to retina
Date:12/13/2011

ROCHESTER, Minn. -- Hitching a ride into the retina on nanoparticles called dendrimers offers a new way to treat age-related macular degeneration and retinitis pigmentosa. A study by investigators at Mayo Clinic, Wayne State University and Johns Hopkins Medicine shows that steroids attached to the dendrimers target the damage-causing cells associated with neuroinflammation, leaving the rest of the eye unaffected and preserving vision. The findings appear in the journal Biomaterials.

Dry age-related macular degeneration and retinitis pigmentosa are caused by neuroinflammation, which progressively damages the retina and can lead to blindness. Macular degeneration is the primary cause of vision loss in older Americans, affecting more than 7 million people, according to the National Institutes of Health. Retinitis pigmentosa encompasses many genetic conditions affecting the retina and impacts 1 in 4,000 Americans, the NIH estimates.

"There is no cure for these diseases," says Mayo Clinic ophthalmologist Raymond Iezzi, M.D., a lead author of the study. "An effective treatment could offer hope to hundreds of millions of patients worldwide."

Iezzi and fellow principal author Rangaramanujam Kannan, Ph.D., an ophthalmology professor at The Wilmer Eye Institute of Johns Hopkins, developed an intracellular, sustained-release drug delivery system. The research, conducted in part at Wayne State University's Kresge Eye Institute with collaboration from Wayne State's College of Engineering and Ligon Research Center of Vision, tested the dendrimer delivery system in rats that develop neuroinflammation.

The target was microglial cells, inflammatory cells in charge of cleaning up dead and dying material in the eye, Dr. Iezzi says. When activated as "trash collectors," the cells cause damage via neuroinflammation -- a hallmark of each disease. The microglial cells gobble up the dendrimers, and the drug then shuts down the cells' activit
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nanoparticles help researchers deliver steroids to retina
2. New device uses gold nanoparticles to test for lung cancer
3. Study indicates nanoparticles could help pain-relieving osteoarthritis drugs last longer
4. Consumers close encounters with nanoparticles
5. UGA researchers use gold nanoparticles to diagnose flu in minutes
6. Gold nanoparticles bring scientists closer to a treatment for cancer
7. Gold nanoparticles help earlier diagnosis of liver cancer
8. Nanoparticles disguised as red blood cells will deliver cancer-fighting drugs
9. Research creates nanoparticles perfectly formed to tackle cancer
10. Good cholesterol nanoparticles seek and destroy cancer cells
11. Research provides new findings on drug delivery with nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2015)... (PRWEB) April 19, 2015 HealthPostures, LLC ... announces that it will exhibit it’s pioneering ergonomics products ... and the Iowa-Illinois Safety Council Professional Development Conference and ... the TaskMate EZ are used in volume by call ... , Built to clamp to a desk, the ...
(Date:4/18/2015)... Carinsurancequotesinfo.com has released a new blog post ... caused by a car accident. , Car ... vehicle. A policy can pay for car repairs and ... always carry appropriate coverage when they are driving. ... with several important riders that offer extra coverage options. ...
(Date:4/18/2015)... 18, 2015 "I wanted to ... create a healthful juice that contained essential vitamins, ... Md. "It increases my energy, improves skin elasticity ... He developed Tapp's Juice to contain fruits, vegetables ... prevent physical and mental fatigue. It features a ...
(Date:4/18/2015)... April 18, 2015 Lower-auto-insurance.com has released ... accurate auto insurance quotes . , Drivers ... by comparing quotes. A professional insurance brokerage website can ... quotes, in a simple, convenient way. The whole process ... anyone. , Comparing online car insurance quotes is ...
(Date:4/18/2015)... More than 2000 styles of newly designed ... #1 online store carrying celebrity inspired special occasion dresses. ... their perfect dresses for their prom. For those who ... at TheCelebrityDresses.com would be an ideal choice. , ... dresses inspired by the most loved styles seen at ...
Breaking Medicine News(10 mins):Health News:HealthPostures' TaskMate Products to be Exhibited at the Wisconsin and Iowa-Illinois Safety Conferences 2Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2
... percent of the U.S. population. Nearly one-third of affected ... bowel movements do not work well. Those who suffer ... research shows biofeedback treatment can successfully retrain muscles. ... laxatives, diet and exercise or another treatment (sham) that ...
... use by young adults significantly boost their risk of stroke, ... to a research. ,In the study, available online in ... than 8,300 stroke patients – ranging in age from 18 ... years 2000 through 2003. ,An analysis of ...
... Psychiatry and Allied Science (RINPAS), one of India's premier mental ... services to reach out to more people. ... attached with the institute," RINPAS director P.K. Chakravarty said Thursday. ... well as hospital inmates. ,RINPAS was set up ...
... a medical care crisis as numbers of students studying geriatric ... of Cincinnati. ,It is estimated that by the ... over the age of 65 in the United States. ... the number of certified geriatricians in the United States has ...
... The amount of prostate-specific antigen (PSA) in a man’s ... or its rate of change over the course of ... according to a study in the April 4 Journal ... with untreated localized prostate cancer have high long-term survival ...
... common antiviral drugs during a recent influenza B epidemic ... resistance to the drugs//, according to a study. ... a type of drugs known as neuraminidase inhibitors, have ... has been documented evidence of the emergence of oseltamivir-resistant ...
Cached Medicine News:Health News:Biofeedback Treats One Type Of Chronic Constipation 2Health News:Biofeedback Treats One Type Of Chronic Constipation 3Health News:Amphetamine, Cocaine Use Increase Risk of Stroke in Young Adults 2Health News:Number of Students Taking Up Geriatric Medicine on the Decline 2Health News:PSA Not a Good Predictor of Lethal Prostate Cancer 2Health News:Study Suggests Some Drug Resistance to Influenza B Medications 2
(Date:4/17/2015)...  Regulatory leaders in the pharmaceutical industry continue to ... "21 st Century Cures." This ... by Congress soon and if enacted into law, it ... developed and marketed in the United States ... to consider how the proposed changes could impact their ...
(Date:4/17/2015)... 17, 2015 Nonin Medical, a global leader ... Chief Operating Officer Steve Bucholz will retire ... expanding his role as Chief Executive Officer. In addition, ... Technology Officer. Operations will transition to David Noel ... has been instrumental to Nonin Medical,s growth," Mr. ...
(Date:4/17/2015)... DUBLIN , Apr. 17, 2015 Research and ... addition of the "Medical Equipment Rental and Leasing ... offering. This report analyzes the worldwide markets ... The report provides separate comprehensive analytics for the US, ... , and Rest of World. Annual estimates ...
Breaking Medicine Technology:21st Century Cures: A Regulatory Game-Changer for the Pharmaceutical Industry 2Nonin Medical's Philip Isaacson Expands CEO Role; President and COO Steve Bucholz to Retire May 1 2Medical Equipment Rental and Leasing Market 2015-2020 - Global Strategic Business Report - Healthcare Spending Slowdown Bodes Well for Medical Equipment Leasing 2
... today launched a new program to help county residents deal ... with the National Association of Counties (NACo), the free Prescription ... offers an average of 24 percent savings off the retail ... be used by those who do not have insurance or ...
... Perrigo Company (Nasdaq: PRGO ; TASE) today ... quarter fiscal 2012 on Thursday, October 27, 2011 at approximately ... at 10:00 a.m. (ET) hosted by Joseph C. Papa, Perrigo,s ... will be available live via webcast to interested parties on ...
Cached Medicine Technology:Yamhill County Introduces Prescription Discount Card to Help Alleviate High Costs 2
... two plastic parts that clamp a corneal ... the patient's cornea like a standard graft. ... since the 1960s and has gradually been ... About 600 implantations have been performed. It ...
A comprehensive CPT surgical, radiological and anesthesia coding reference....
Provides quick access to information needed to make diagnoses and treatment decisions....
PDA application containing all 7,000+ Physicians' Current Procedural Terminology codes developed by the American Medical Association....
Medicine Products: