Navigation Links
Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
Date:6/15/2012

Researchers from the University of Notre Dame have engineered nanoparticles that show great promise for the treatment of multiple myeloma (MM), an incurable cancer of the plasma cells in bone marrow.

One of the difficulties doctors face in treating MM comes from the fact that cancer cells of this type start to develop resistance to the leading chemotherapeutic treatment, doxorubicin, when they adhere to tissue in bone marrow.

"The nanoparticles we have designed accomplish many things at once," says Başar Bilgier, assistant professor of chemical and biomolecular engineering and chemistry and biochemistry, and an investigator in Notre Dame's Advanced Diagnostics and Therapeutics (AD&T) initiative.

"First, they reduce the development of resistance to doxorubicin. Second, they actually get the cancer cells to actively consume the drug-loaded nanoparticles. Third, they reduce the toxic effect the drug has on healthy organs."

A sequence of images showing multiple myeloma cells internalizing the engineered nanoparticles

The nanoparticles are coated with a special peptide that targets a specific receptor on the outside of multiple myeloma cells. These receptors cause the cells to adhere to bone marrow tissue and turn on the drug resistance mechanisms. But through the use of the newly developed peptide, the nanoparticles are able to bind to the receptors instead and prevent the cancer cells from adhering to the bone marrow in the first place.

The particles also carry the chemotherapeutic drug with them. When a particle attaches itself to an MM cell, the cell rapidly takes up the nanoparticle, and only then is the drug released, causing the DNA of cancer cell to break apart and the cell to die.

"Our research on mice shows that the nanoparticle formulation reduces the toxic effect doxorubicin has on other tissues, such as the kidneys and liver," adds Tanyel Kiziltepe, a research assistant professor with the Department of Chemical and Biomolecular Engineering and AD&T.

"We believe further research will show that the heart is less affected as well. This could greatly reduce the harmful side-effects of this chemotherapy."

The group had to tackle three important problems associated with all nanoparticle-based therapies, explains Jonathan Ashley, one of the leading researchers of the project.

"There was some complex bioengineering involved in developing the particles. We were able to precisely control the number of drug and targeting elements on each nanoparticle, achieve homogeneous nanoparticle size distribution and eliminate the batch-to-batch variability in particle production."

Before advancing to human clinical trials, the team plans further research and testing to improve the design of the nanoparticles and to find the optimum amount and combination of chemotherapy drugs for this new treatment.

The research is described in greater detail in a recent edition of Nature's Blood Cancer Journal. It was supported by funding from the Indiana Clinical and Translational Sciences Institute.


'/>"/>

Contact: Başar Bilgier
bbilgicer@nd.edu
574-631-1429
University of Notre Dame
Source:Eurekalert

Related medicine news :

1. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
2. Early Study Finds Some Promise for Lung Cancer Vaccine
3. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
4. Nonsurgical Method to Measure Brain Pressure Shows Promise
5. Immunotherapy for elderly cancer patients finds new promise in drug combination
6. Experimental Pill for Multiple Sclerosis Shows Promise
7. Mechanical tissue resuscitation technology shows promise
8. Brain Tumor Vaccine Shows Promise in Early Trial
9. New Method to Reveal Alzheimers Marker Shows Promise
10. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
11. New Drug Shows Promise for Myeloma Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ... March 30, 2017 , ... An inventor and manicurist from Greet, S.C., wants to ... I try to help customers maintain clean and healthy feet, so I know the importance ... their feet at home, I designed the FOOT-TRAN SYSTEM." , The FOOT-TRAN SYSTEM enables a ...
(Date:3/29/2017)... ... March 29, 2017 , ... During the last week ... free screening colonoscopies to eligible individuals in the local community. , Colon cancer ... regular screenings can detect colon cancer while it is small, confined and easier to ...
(Date:3/29/2017)... ... March 29, 2017 , ... Full Contact K9, an Atlanta-based ... Pet Protect Law that assists dog owners in creating legally-enforceable pet trusts for ... taking the natural next step to protect their new companion. Says Evan Dunbar, CEO ...
(Date:3/29/2017)... Petersburg, FL (PRWEB) , ... March 30, 2017 , ... ... called the "Spice of Life" or "Wonder Spice", it has been used for thousands ... use in the East," says Heshelow, author of " Turmeric: How to Use it ...
(Date:3/29/2017)... ... March 29, 2017 , ... The Wall Centre ... to new patients from Burnaby, BC. Patients in need of experienced orthodontics, laser ... can see the esteemed team at Wall Centre Dental. Drs. Parviz Roshan, Siamak ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... Mar. 29, 2017 Research and Markets ... Market Size & Forecast By Type (Insource IONM, Outsource IONM), ... report to their offering. ... The global Intraoperative Neuromonitoring (IONM) market ... intraoperative neuromonitoring market is anticipated to witness significant growth in ...
(Date:3/29/2017)... , Mar. 29, 2017 Research and Markets ... Market 2017-2021" report to their offering. ... The global energy-based aesthetic devices market ... The report, Global Energy-Based Aesthetic Devices Market 2017-2021, ... from industry experts. The report covers the market landscape and its ...
(Date:3/29/2017)... SAN DIEGO , March 29, 2017 Avelas Biosciences, ... care from diagnosis through treatment, today announced that Carmine N. ... of the company at the Needham & Company 16 th ... EDT (8:20 a.m. PDT) at the Westin Grand Central Hotel in ... Biosciences ...
Breaking Medicine Technology: