Navigation Links
Nanoparticles disguised as red blood cells will deliver cancer-fighting drugs
Date:6/20/2011

Researchers at the University of California, San Diego have developed a novel method of disguising nanoparticles as red blood cells, which will enable them to evade the body's immune system and deliver cancer-fighting drugs straight to a tumor. Their research will be published next week in the online Early Edition of the Proceedings of the National Academy of Sciences.

The method involves collecting the membrane from a red blood cell and wrapping it like a powerful camouflaging cloak around a biodegradable polymer nanoparticle stuffed with a cocktail of small molecule drugs. Nanoparticles are less than 100 nanometers in size, about the same size as a virus.

"This is the first work that combines the natural cell membrane with a synthetic nanoparticle for drug delivery applications." said Liangfang Zhang, a nanoeningeering professor at the UC San Diego Jacobs School of Engineering and Moores UCSD Cancer Center. "This nanoparticle platform will have little risk of immune response".

Researchers have been working for years on developing drug delivery systems that mimic the body's natural behavior for more effective drug delivery. That means creating vehicles such as nanoparticles that can live and circulate in the body for extended periods without being attacked by the immune system. Red blood cells live in the body for up to 180 days and, as such, are "nature's long-circulation delivery vehicle," said Zhang's student Che-Ming Hu, a UCSD Ph.D. candidate in bioengineering, and first author on the paper.

Stealth nanoparticles are already used successfully in clinical cancer treatment to deliver chemotherapy drugs. They are coated in a synthetic material such as polyethylene glycol that creates a protection layer to suppress the immune system so that the nanoparticle has time to deliver its payload. Zhang said today's stealth nanoparticle drug delivery vehicles can circulate in the body for hours compared to the minutes
'/>"/>

Contact: Catherine Hockmuth
chockmuth@ucsd.edu
858-822-1359
University of California - San Diego
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Research creates nanoparticles perfectly formed to tackle cancer
2. Good cholesterol nanoparticles seek and destroy cancer cells
3. Research provides new findings on drug delivery with nanoparticles
4. Nanoparticles increase survival after blood loss
5. Nanoparticles may enhance circulating tumor cell detection
6. New nanoparticles make blood clots visible
7. Special sugar, nanoparticles combine to detect cholera toxin
8. Delivering a potent cancer drug with nanoparticles can lessen side effects
9. Einstein-Montefiore researcher will test nanoparticles against pancreatic cancer
10. Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
11. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... June 19, 2013 Middle market merger ... across all industries as cash rich buyers seek to ... across industries, all M&A transactions have a good deal ... to verify the history and quality of the target ... , But when due diligence involves a middle market ...
(Date:6/18/2013)... June 19, 2013 oBand Surgery Centers, ... are holding complimentary weight loss seminars in Los Angeles ... can be accessed at their official website. oBand Surgery ... recovery time. Their highly skilled panel of surgeons and ... , A senior executive working with oBand Surgery ...
(Date:6/18/2013)... PA, June 19, 2013 Recent studies linking ... of bullying-related suicide among young people, led the ... assemble an expert panel to focus on these ... the complex relationship between youth involvement in bullying ... among youth is a significant public health problem, ...
(Date:6/18/2013)... June 18, 2013 Cheap Concert Tickets has ... the tournament which gets underway in July. Soccer fans ... CONCACAF ticket order. , The popularity and hype ... the globe.    In fact, the hype of the game triggered the ... also trickled down the veins of fans from the Caribbean. ...
(Date:6/18/2013)... The Drug Delivery Partnering Terms and ... the drug delivery partnering deals and agreements entered into ... report provides a detailed understanding and analysis of how ... majority of deals are discovery or development stage whereby ... to license the license drug delivery technology. These deals ...
Breaking Medicine News(10 mins):Health News:Newport Board Group, a National Business Advisory Firm of CEOs Cautions Buyers on 5 Questions to Ask Before Acquiring a Technology-Based Middle Market Company 2Health News:Newport Board Group, a National Business Advisory Firm of CEOs Cautions Buyers on 5 Questions to Ask Before Acquiring a Technology-Based Middle Market Company 3Health News:oBand Surgery Centers Will Hold Complimentary Weight Loss Seminars in Los Angeles in June 2Health News:Bullying and suicide among youth is a public health problem 2Health News:CONCACAF Tickets Have Been Released for Martinique, Mexico, Panama, El Salvador, Trinidad, Tobago, Haiti, Honduras, Costa Rica, Cuba, Belize, US, Canada, Honduras & Cuba 2Health News:CONCACAF Tickets Have Been Released for Martinique, Mexico, Panama, El Salvador, Trinidad, Tobago, Haiti, Honduras, Costa Rica, Cuba, Belize, US, Canada, Honduras & Cuba 3Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 2Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 3Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 4
... police officers, school leaders, in addition to the East ... break out. // Officials belonging to these departments are ... department everywhere has to be at the forefront while ... epidemics in the past which had devastated whole civilizations. ...
... of Biological Sciences, University of Southampton have reported that ... to inhibit the growth of Influenza A virus. In ... copper reduced the Plaque Forming Units (PFU) of Influenza ... there is an increased world wide threat of bird ...
... suffer from asthmatic symptoms, carrying a girl foetus are more ... a male foetus, // according to a recent study. Michael ... studied 702 pregnant women throughout southern New England who were ... selected points in pregnancy. ,Lung function and ...
... to India for the sake of low priced cosmetic ... waistline, rhinoplasty, and breast improvements are very expensive. // ... UK every year. ,Recent figures released ... that breast enlargement topped the list of cosmetic operations ...
... Lords committee report has revealed that about 90% of ... not actually been tested on children. Drugs like thyrozine, ... to children in spite of them not being licensed ... given to children have not undergone proper tests with ...
... Researchers belonging to the Oxford University in England have revealed ... their own treatment and taught to scale down the risk ... be avoided. Those patients who change the doses of warfarin, ... blood run the risk of dying within two years, which ...
Cached Medicine News:Health News:More People Come To India For Cosmetic Surgery 2
(Date:6/18/2013)... 2013  Decision Resources, one of the world,s ... healthcare issues, announces that its Market Access Tracker ... Middle East and Africa ... and opportunities to gaining and maintaining favorable market ... countries. The countries covered by Market Access Tracker ...
(Date:6/18/2013)... -- Today, Wall Street Reports announced new research ... Health Management Associates Inc. (NYSE: HMA ), IDEXX ... (NASDAQ: ISIS ), and Trius Therapeutics Inc. (NASDAQ: ... - including full price targets, industry analysis and analyst ratings ... Research Report On June 7, 2013, Gilead Sciences ...
(Date:6/18/2013)... BASKING RIDGE, N.J. , June 18, 2013 /PRNewswire/ ... Adrian Peterson and professional family expert ... are partnering with Mylan Specialty L.P., the fully integrated ... MYL ), to raise awareness of this significant health ... of the U.S. Food and Drug Administration (FDA) approval ...
Breaking Medicine Technology:Decision Resources' Market Access Tracker Now Covers the Middle East and Africa 2Decision Resources' Market Access Tracker Now Covers the Middle East and Africa 3Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 2Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 3Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 4Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 5Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 6Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 2Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 3Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 4Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 5Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 6Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 7Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 8
... /PRNewswire-Asia/ -- Golden Meditech Holdings Limited ("Golden ... - 801.HK; 910801.TW), a leading healthcare enterprise in China, ... China Holdings Limited, the Group,s associate, for US$15 million. ... FunTalk China will be reduced 19.8%.  The Group will ...
... Medical Alarm Concepts Holding, Inc. (OTCQB:MDHI), manufacturer of the ... the users to speak and listen directly through the ... corporate activities. The following comments are from Medical Alarm ... the past several months we have been relatively quiet ...
Cached Medicine Technology:Golden Meditech Disposes of 2.0% Stake in FunTalk China for US$15 Million 2Medical Alarm Concepts Investor Update - Several Initiatives in Place Designed to Significantly Accelerate Growth 2Medical Alarm Concepts Investor Update - Several Initiatives in Place Designed to Significantly Accelerate Growth 3
High intensity lamp with built-in, switchable spare lamp. Low-noise fan with reduced air turbulence....
... of two plastic parts that clamp a ... into the patient's cornea like a standard ... development since the 1960s and has gradually ... 1992. About 600 implantations have been performed. ...
PDA application providing complex evaluation and management coding rule interactive templates....
PDA-version of the complete ICD-9 diagnosis codes....
Medicine Products: