Navigation Links
Nanoparticles disguised as red blood cells will deliver cancer-fighting drugs
Date:6/20/2011

Researchers at the University of California, San Diego have developed a novel method of disguising nanoparticles as red blood cells, which will enable them to evade the body's immune system and deliver cancer-fighting drugs straight to a tumor. Their research will be published next week in the online Early Edition of the Proceedings of the National Academy of Sciences.

The method involves collecting the membrane from a red blood cell and wrapping it like a powerful camouflaging cloak around a biodegradable polymer nanoparticle stuffed with a cocktail of small molecule drugs. Nanoparticles are less than 100 nanometers in size, about the same size as a virus.

"This is the first work that combines the natural cell membrane with a synthetic nanoparticle for drug delivery applications." said Liangfang Zhang, a nanoeningeering professor at the UC San Diego Jacobs School of Engineering and Moores UCSD Cancer Center. "This nanoparticle platform will have little risk of immune response".

Researchers have been working for years on developing drug delivery systems that mimic the body's natural behavior for more effective drug delivery. That means creating vehicles such as nanoparticles that can live and circulate in the body for extended periods without being attacked by the immune system. Red blood cells live in the body for up to 180 days and, as such, are "nature's long-circulation delivery vehicle," said Zhang's student Che-Ming Hu, a UCSD Ph.D. candidate in bioengineering, and first author on the paper.

Stealth nanoparticles are already used successfully in clinical cancer treatment to deliver chemotherapy drugs. They are coated in a synthetic material such as polyethylene glycol that creates a protection layer to suppress the immune system so that the nanoparticle has time to deliver its payload. Zhang said today's stealth nanoparticle drug delivery vehicles can circulate in the body for hours compared to the minutes
'/>"/>

Contact: Catherine Hockmuth
chockmuth@ucsd.edu
858-822-1359
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Research creates nanoparticles perfectly formed to tackle cancer
2. Good cholesterol nanoparticles seek and destroy cancer cells
3. Research provides new findings on drug delivery with nanoparticles
4. Nanoparticles increase survival after blood loss
5. Nanoparticles may enhance circulating tumor cell detection
6. New nanoparticles make blood clots visible
7. Special sugar, nanoparticles combine to detect cholera toxin
8. Delivering a potent cancer drug with nanoparticles can lessen side effects
9. Einstein-Montefiore researcher will test nanoparticles against pancreatic cancer
10. Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
11. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... On Monday, August 18th, The ... suffered by Community Health Systems, which operates over ... million records containing Personally Identifiable Information (PII) like names, ... who was engaged to investigate the incident, the belief ... of cyber attackers based in China, who they say ...
(Date:8/23/2014)... August 23, 2014 Pixel Film Studios, a ... today the release of ProIntro Vol.3, a customizable title ... and professional tile just by dragging ProIntro Vol.3 in their ... Vol.3 is a definite time saver and i think our ... with 30 beautifully designed titles made with Final Cut Pro ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 Teen drug ... Carolina. It’s no different in Wilmington, NC. Substance abuse ... are falling victim to drug and alcohol dependency in ... are looking to overcome substance abuse, but don’t know ... adolescent treatment facility can be a challenge because most ...
(Date:8/22/2014)... IT manager of Top10BestSEOHosting.com is a web professional who ... recently announced that GoDaddy ( http://www.top10bestseohosting.com/go/GoDaddy.com/ ) is one ... is a popular supplier of cheap web hosting, and ... affordable rates. It offers three Linux shared hosting plans. ... the length of the contract. The longest contract length ...
(Date:8/22/2014)... UT (PRWEB) August 22, 2014 Today, ... a new guide on Account-Based Health Plans. , According ... (ABHPs) as a strategy to lower the cost of ... types of medical spending accounts, however, can be confusing. ... chart to learn the four main types of ABHPs. ...
Breaking Medicine News(10 mins):Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 2Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 3Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 4Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2
... 4 Clarient, Inc. (Nasdaq: CLRT ), a ... pharmaceutical industry, today announced that it has rescheduled the release ... December 31, 2008 to Wednesday, March 11th in order to ... with the filing of its Form 10-K for the year ...
... the CDC website can be a frightening experience for ... two million patients will acquire a hospital infection this ... as a result. CDC studies found that hospital infections ... additional days to a hospital stay on average, costing ...
... MOUNTAIN VIEW, Calif., March 4 Based ... and biotechnology market, Frost & Sullivan presents ... American Frost & Sullivan Award for Entrepreneurial ... the company,s success in achieving its growth ...
... quarter net service revenues increased 84% to $66.2 million; ... million- Fourth quarter Visiting Nurse (VN) segment net revenues ... revenues rose 80% to $173.0 million- Fourth quarter net ... income increased 114% to $16.3 million- Fourth quarter diluted ...
... TouchOut Cancer, the first cancer news iPhone application, features daily cancer ... The Leukemia & Lymphoma Society and I,m Too Young For This ... Bryan Clay and more. , ... Chicago, IL (PRWEB) ...
... a leader in the healthcare documentation training industry, will release a ... of March. This program was developed in collaboration with industry experts ... growing medical coding and billing industry. , ... Springville, ...
Cached Medicine News:Health News:Clarient Reschedules Fourth Quarter and Year-End 2008 Financial Results Release To Wednesday, March 11th; Conference Call and Webcast Rescheduled For 5:00 PM EDT That Day 2Health News:Mercy Hospital at Folsom Acquires Advanced Germicidal Technology to Battle MRSA, C. diff, Acinetobacter and Other Drug-Resistant Pathogens 2Health News:Frost & Sullivan Lauds OVATION Pharmaceuticals for Its Business Model and Ability to Sustain Growth 2Health News:Frost & Sullivan Lauds OVATION Pharmaceuticals for Its Business Model and Ability to Sustain Growth 3Health News:Frost & Sullivan Lauds OVATION Pharmaceuticals for Its Business Model and Ability to Sustain Growth 4Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 2Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 3Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 4Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 5Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 6Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 7Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 8Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 9Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 10Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 11Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 12Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 13Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 14Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 15Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 16Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 17Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 18Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 19Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 20Health News:MedicinePhone Launches TouchOut Cancer on Apple App Store 2Health News:MedicinePhone Launches TouchOut Cancer on Apple App Store 3Health News:Career Step Launches New Training Program for Careers in Secure Healthcare Industry 2
(Date:8/22/2014)... 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today announced ... of common stock and warrants at a price of ... prior to deducting underwriting discounts and commissions and offering ... are immediately separable and will be issued separately.  The ... on The NASDAQ Stock Market under the ticker symbol ...
(Date:8/21/2014)... HOUSTON , Aug. 21, 2014   Memorial Hermann ... Anderson Cancer Center today announced a new partnership to ... network of community breast care centers in the greater ... November, MD Anderson will become the exclusive provider of professional ... care centers, located in Memorial City, The Woodlands ...
(Date:8/21/2014)... Ill. , Aug. 21, 2014 ... Baxter International Inc. today announced positive results from ... 855, an investigational, extended half-life recombinant factor VIII ... [Antihemophilic Factor (Recombinant)], which met its primary endpoint ... prophylaxis arm compared to the on-demand arm. ...
Breaking Medicine Technology:WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5
... LLC is pleased to announce that it has been ... Human Research Protection Programs (AAHRPP) at the September meeting ... in the Kansas City metro area, Mid*Lands is an ... welfare of research study participants. Mid*Lands IRB specializes in ...
... More than 1,700 medical device and diagnostics ... 24 countries and 33 states – attended the ... MedTech Conference this week in Washington, D.C. ... (Photo:   http://www.newscom.com/cgi-bin/prnh/20101022/DC86995-a ) ...
Cached Medicine Technology:Mid*Lands IRB, LLC - First Independent IRB in Kansas and the Kansas City Area Awarded Accreditation for Protecting Research Participants 2AdvaMed 2010 Sets New Attendance Record: More than 1,700 Device and Diagnostics Leaders from Across the Country and Around the World Came to Washington, D.C. 2
... An Precise placement integrated with the CRW ... offers a unique off-board cable drive mechanism ... drive without the problem of fluid leakage. ... for future upgrades and simplified removal during ...
... The OEV-203 Monitors are designed exclusively for ... use with all Olympus endoscopy systems. When ... equipment, the OEV-203 provides sharp, high-resolution images ... with the view - and details - ...
... It features over 600 TV lines of resolution ... four color temperature selections, scanning size selection and ... allows the user to easily set up and ... for brightness, chroma, phase, contrast, volume and aperture ...
... flat panel is designed for medical imaging. The 18 ... radiology and ultrasound. It can be mounted on a ... arm. It allows for RGB, s-video and composite inputs ... built in VGA input. In VGA mode, its resolution ...
Medicine Products: