Navigation Links
Nanoparticles detect biochemistry of inflammation
Date:9/18/2012

Inflammation is the hallmark of many human diseases, from infection to neurodegeneration. The chemical balance within a tissue is disturbed, resulting in the accumulation of reactive oxygen species (ROS) such as hydrogen peroxide, which can cause oxidative stress and associated toxic effects.

Although some ROS are important in cell signaling and the body's defense mechanisms, these chemicals also contribute to and are indicators of many diseases, including cardiovascular dysfunction. A non-invasive way of detecting measurable, low levels of hydrogen peroxide and other ROS would provide a viable way to detect inflammation. Such a method would also provide a way to selectively deliver drugs to their targets.

Adah Almutairi, PhD, associate professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences, the Department of NanoEngineering, and the Materials Science and Engineering Program at the University of California, San Diego, and colleagues have developed the first degradable polymer that is extremely sensitive to low but biologically relevant concentrations of hydrogen peroxide.

Their work is currently published in the online issue of the Journal of the American Chemical Society.

These polymeric capsules, or nanoparticles, are taken up by macrophages and neutrophils immune system cells that rush to the site of inflammation. The nanoparticles then release their contents when they degrade in the presence of hydrogen peroxide produced by these cells.

"This is the first example of a biocompatible way to respond to oxidative stress and inflammation," said Almutairi, director of the UC San Diego Laboratory of Bioresponsive Materials. "Because the capsules are tailored to biodegrade and release their cargo when encountering hydrogen peroxide, they may allow for targeted drug delivery to diseased tissue."

Almutairi is looking to test this method in a model of atherosclerosis. "Cardiologists have long needed a non-invasive method to determine which patients are vulnerable to a heart attack caused by ruptured plaque in the arteries before the attack," she said. "Since the most dangerous of plaques is inflamed, our system could provide a safe way to detect and treat this disease."


'/>"/>

Contact: Debra Kain
619-543-6163
University of California - San Diego
Source:Eurekalert  

Related medicine news :

1. Improved nanoparticles deliver drugs into brain
2. UCSB scientists examine effects of manufactured nanoparticles on soybean crops
3. New nanoparticles shrink tumors in mice
4. Researchers find gold nanoparticles capable of unzipping DNA
5. Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
6. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
7. Technique using CT linked with improved detection of lymph node metastasis in patients with melanoma
8. Pharmacists provide additional line of defense for detecting knee osteoarthritis
9. Unexpected findings at multi-detector CT scans: Less reason to worry
10. Virus detector harnesses ring of light in whispering gallery mode
11. Sensor detects glucose in saliva and tears for diabetes testing
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoparticles detect biochemistry of inflammation
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... integration of the CareFusion NOX-T3 portable sleep monitor with its Somnoware Sleep Device ... consistent, browser-based interface for diagnostic device operations. With this platform, initializing devices and ...
(Date:5/26/2017)... ... May 26, 2017 , ... On May 24, the Congressional ... passed the U.S. House on May 4, would result in 23 million Americans losing ... implementation of the 2010 Patient Protection and Affordable Care Act (ACA). , “It ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... Rob Lowe ... An upcoming production of the series is on hiking in American. Viewers can reconnect ... of the great benefits of hiking. , Many consumers have looked for an inventive ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... be this year’s recipient of proceeds from its 14th Annual Clays for Kids ... E. County Road 30, Bennett, Colorado. , As part of BluSky’s partnership ...
(Date:5/24/2017)... ... 24, 2017 , ... Last month, representatives from Rendina Healthcare ... town officials to celebrate the grand opening of the 87,000 square foot medical ... of its ongoing relationship with RWJBarnabas Health, New Jersey’s largest health system. Two ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of the ... based on extensive data analysis from GHI,s hospitals database ... database for the region. The GHI database covers 86% of ... more than 130 data points for each institution in key ...
(Date:5/9/2017)... 9, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... today announced it has earned a spot on ... The Company was ranked among 500 U.S. employers as ... Healthcare Equipment and Services. The annual ... anonymous, independent survey of over 30,000 employees across 25 ...
(Date:5/8/2017)... YORK , May 8, 2017 ... the transition from fee for service reimbursement. Black Book ... 2017. 1.       The Market for MIPS ... 77% of physician practices with 3 or more ... Technology Solutions by Q4. "Given the magnitude of the ...
Breaking Medicine Technology: