Navigation Links
Nanoparticles aid bone growth
Date:6/13/2008

In the first study of its kind, bioengineers and bioscientists at Rice University and Radboud University in Nijmegen, Netherlands, have shown they can grow denser bone tissue by sprinkling stick-like nanoparticles throughout the porous material used to pattern the bone.

The research is available online and slated to appear in the journal Bone. It's the latest breakthrough from the burgeoning field of tissue engineering. The new discipline combines the latest research in materials science and biomedical engineering to produce tissues that can be transplanted without risk of rejection.

To grow new bone, tissue engineers typically place bone cells on porous, biodegradable materials called scaffolds, which act as patterns. With the right chemical and physical cues, the cells can be coaxed into producing new bone. As the scaffold degrades, it is replaced by new bone.

"Ideally, a scaffold should be highly porous, nontoxic and biodegradable, yet strong enough to bear the structural load of the bone that will eventually replace it," said lead researcher Antonios Mikos, Rice's J.W. Cox Professor in Bioengineering, professor of chemical and biomolecular engineering and the director of Rice's Center for Excellence in Tissue Engineering. "Previous research has shown that carbon nanotubes give added strength to polymer scaffolds, but this is the first study to examine the performance of these materials in an animal model."

In the experiments, the researchers implanted two kinds of scaffolds into rabbits. One type was made of a biodegradable plastic called poly(propylene fumarate), or PPF, which has performed well in previous experiments. The second was made of 99.5 percent PPF and 0.5 percent single-walled carbon nanotubes. Nanotubes are about 80,000th the width of a hair. While they are normally about a thousand times longer than they are wide, the researchers used shorter segments that have fared well in prior cytocompatibility studies.

Half the samples were examined four weeks after implantation and half after 12 weeks. While there was no notable difference in performance at four weeks, the nanotube composites exhibited up to threefold greater bone ingrowth after 12 weeks than the PPF. Furthermore, the researchers found the 12-week composite scaffolds contained about two-thirds as much bone tissue as the nearby native bone tissue, while the PPF contained only about one-fifth as much.

Mikos said the nanocomposites performed better than anticipated. In fact, the results indicate that they may go beyond passive guides and take an active role in promoting bone growth.

"We don't yet know the exact mechanism of this enhanced bone formation, but we have intensive studies under way to find out," Mikos said. "It could be related to changes in surface chemistry, strength or other factors."


'/>"/>

Contact: B.J. Almond
balmond@rice.edu
713-348-6770
Rice University
Source:Eurekalert

Related medicine news :

1. Magnetic nanoparticles: Suitable for cancer therapy?
2. Brown chemists create cancer-detecting nanoparticles
3. Iowa State University researcher looks to use nanoparticles for food safety
4. Symposium to explore role nanoparticles may play in disease
5. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
6. Insulet Corporation to Present at the William Blair & Company 28th Annual Growth Stock Conference on June 19, 2008
7. Primary tumors can drive the growth of distant cancers
8. Primary Tumors Fuel Growth of Cancer Cells
9. Cancer-killing viruses influence tumor blood-vessel growth
10. Medco to Present at the William Blair & Company, L.L.C. 28th Annual Growth Conference
11. SAIC to Webcast Presentation at William Blair Growth Stock Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... MA (PRWEB) , ... June 23, 2017 , ... ... Care Reconciliation Act (BCRA), their proposed healthcare bill to repeal and replace the ... May, the Senate bill would make significant cuts to Medicaid, a public health ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference when ... read it, and some people don't like it at all. FindaTopDoc took a look ... , Erotic literature can give readers a taste of their deepest, darkest fantasies and ...
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and South Asia Leaders Selected ... from government, business and civil society in 11 countries across the Middle East and ... in a transformative exchange of knowledge and ideas with the leading minds in their ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ulster University, Magee Campus in Northern Ireland is ... 3 pm to present to graduate students exciting new and innovative hope research based ... led by The Health Improvement Service of the Western Health & Social Care Trust ...
(Date:6/23/2017)... ... June 23, 2017 , ... Moore Insurance, an eastern Texas ... to asset protection and financial planning services, is teaming up with the For ... of children with cancer and other chronic diseases. , The For A Day ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... 2017 The Cincinnati location ... Inc. (NYSE: DPLO), has been awarded a Top Workplaces ... Results are based on an employee survey administered by ... workplace improvement. The survey measures several aspects of workplace culture, ... ...
(Date:6/3/2017)... -- Eli Lilly and Company (NYSE: LLY ... 3 MONARCH 2 study showed that abemaciclib, a ... with fulvestrant, significantly improved progression-free survival (PFS) compared ... hormone-receptor-positive (HR+), human epidermal growth factor receptor 2-negative ... progressed after endocrine therapy (median PFS, 16.4 vs. ...
(Date:6/1/2017)... , June 1, 2017 Nutriceutical Holdings (NH), ... Recommended Solutions (VRS), and KD Pharma Group have decided ... Holdings by KD Pharma Group. KD Pharma Group will ... option to acquire the entire company. "We ... They are committed to growing the NH companies by ...
Breaking Medicine Technology: