Navigation Links
Nanoparticles May Help Attack Cancer More Directly
Date:4/25/2009

Method tested in mice could allow more potent treatment with fewer side effects

SATURDAY, April 25 (HealthDay News) -- Nanoparticles designed to provide more direct delivery of cancer drugs to tumors have been developed by U.S. researchers.

Made from a safe, biodegradable polymer, the nanoparticles are chemically engineered to inhibit the MARK signaling pathway, which is involved in most human tumors, and to carry a higher concentration of anti-cancer drugs to a specific area, according to the scientists at Brigham and Women's Hospital and the Harvard-MIT Division of Health Sciences and Technology.

By inhibiting the MARK signaling pathway, the nanoparticles hinder the multiplication of cancer cells and make the cells more susceptible to chemotherapy drugs. The researchers also modified the polymer used in the nanoparticles to increase drug loading 20-fold to overcome what they describe as a current drawback in nanomedicine -- low efficiency of drug loading.

"Current chemotherapy drugs must be administered in high concentration throughout the body in order to destroy tumor cells, translating to high toxicity and discomfort for the patient, mainly due to the effects on normal cells," co-lead author Rania Harfouche said in a Brigham and Women's news release.

The new nanoparticles would "allow for lower drug concentrations to be used, and provide opportunity for more potent treatments with lesser side-effects for the patient," Harfouche said.

In lab tests, nanoparticles loaded with the cancer drug cisplatin prevented the growth of cancerous skin and lung cells and also triggered cell death. When used in mice, the drug-loaded nanoparticles inhibited tumor growth, the researchers reported.

The research was published online in this week's issue of the Proceedings of the National Academy of Sciences.

"The nanoparticles target pathways involved in multiple cancer types and can be applied to a diverse set of cancers, including hard-to-treat cancers, such as breast, pancreatic and liver cancer," senior author Shiladitya Sengupta said in the news release. "The potential to add homing beacons on the surface of the nanoparticles can increase the efficiency of selectively targeting specific tumors and abolish off-target side effects."

More information

The U.S. National Cancer Institute has more about chemotherapy.



-- Robert Preidt



SOURCE: Brigham and Women's Hospital, news release, April 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Symposium to explore role nanoparticles may play in disease
3. Iowa State University researcher looks to use nanoparticles for food safety
4. Brown chemists create cancer-detecting nanoparticles
5. Magnetic nanoparticles: Suitable for cancer therapy?
6. Nanoparticles aid bone growth
7. Using magenetic nanoparticles to combat cancer
8. Nanoparticles + light = dead tumor cells
9. New disease-fighting nanoparticles look like miniature pastries
10. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
11. Consumers Union Urges FDA to Conduct Full Scale Safety Review of Nanoparticles in Sunscreen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoparticles May Help Attack Cancer More Directly
(Date:5/24/2016)... ... May 24, 2016 , ... ... Cifolelli has joined the company as Vice President of Sales. Cifolelli’s primary ... and international sales in the rapidly expanding field of organizational social engineering. ...
(Date:5/24/2016)... ... May 24, 2016 , ... i2i, ... identity and website at its “Transforming Outcomes” User Conference in Las Vegas on ... i2i’s ongoing success to set the market standard for meaningful population health management. ...
(Date:5/24/2016)... ... May 24, 2016 , ... Educational opportunities, ... housing, with more advantaged communities providing richer opportunities. Recognizing the key role of ... school improvement policies; (b) school choice policies; (c) school desegregation policies; (d) wealth-focused ...
(Date:5/24/2016)... Georgia (PRWEB) , ... May 24, 2016 , ... Mental ... 1969 by the Church of Scientology and renowned professor of psychiatry Thomas Szasz, is ... of its “Psychiatry: An Industry of Death” exhibit in Atlanta, Georgia. The opening of ...
(Date:5/24/2016)... NY (PRWEB) , ... May 24, 2016 , ... ... treatment for physical disease or injury that focuses on repairing the musculoskeletal and ... , With an emphasis on functional restoration, NYDNRehab began providing treatments for physical ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LAWRENCE, Mass. , May 24, 2016  NxStage ... medical technology company focused on advancing renal care, today ... Officer, plans to participate in the following schedule of ... will be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, ...
(Date:5/24/2016)... May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior vice president ... today. In his new role, Marziani will lead the company,s business development and sales ... improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... , May 24, 2016 ... doble terapia del mundo, introduce catéteres para la ... OrbusNeich, una compañía global especializada en el ... ha expandido su cartera incluyendo productos para tratar ... y Scoreflex™ PTA son los dispositivos de primera ...
Breaking Medicine Technology: