Navigation Links
Nanoparticles May Help Attack Cancer More Directly
Date:4/25/2009

Method tested in mice could allow more potent treatment with fewer side effects

SATURDAY, April 25 (HealthDay News) -- Nanoparticles designed to provide more direct delivery of cancer drugs to tumors have been developed by U.S. researchers.

Made from a safe, biodegradable polymer, the nanoparticles are chemically engineered to inhibit the MARK signaling pathway, which is involved in most human tumors, and to carry a higher concentration of anti-cancer drugs to a specific area, according to the scientists at Brigham and Women's Hospital and the Harvard-MIT Division of Health Sciences and Technology.

By inhibiting the MARK signaling pathway, the nanoparticles hinder the multiplication of cancer cells and make the cells more susceptible to chemotherapy drugs. The researchers also modified the polymer used in the nanoparticles to increase drug loading 20-fold to overcome what they describe as a current drawback in nanomedicine -- low efficiency of drug loading.

"Current chemotherapy drugs must be administered in high concentration throughout the body in order to destroy tumor cells, translating to high toxicity and discomfort for the patient, mainly due to the effects on normal cells," co-lead author Rania Harfouche said in a Brigham and Women's news release.

The new nanoparticles would "allow for lower drug concentrations to be used, and provide opportunity for more potent treatments with lesser side-effects for the patient," Harfouche said.

In lab tests, nanoparticles loaded with the cancer drug cisplatin prevented the growth of cancerous skin and lung cells and also triggered cell death. When used in mice, the drug-loaded nanoparticles inhibited tumor growth, the researchers reported.

The research was published online in this week's issue of the Proceedings of the National Academy of Sciences.

"The nanoparticles target pathways involved in multiple cancer types and can be applied to a diverse set of cancers, including hard-to-treat cancers, such as breast, pancreatic and liver cancer," senior author Shiladitya Sengupta said in the news release. "The potential to add homing beacons on the surface of the nanoparticles can increase the efficiency of selectively targeting specific tumors and abolish off-target side effects."

More information

The U.S. National Cancer Institute has more about chemotherapy.



-- Robert Preidt



SOURCE: Brigham and Women's Hospital, news release, April 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Symposium to explore role nanoparticles may play in disease
3. Iowa State University researcher looks to use nanoparticles for food safety
4. Brown chemists create cancer-detecting nanoparticles
5. Magnetic nanoparticles: Suitable for cancer therapy?
6. Nanoparticles aid bone growth
7. Using magenetic nanoparticles to combat cancer
8. Nanoparticles + light = dead tumor cells
9. New disease-fighting nanoparticles look like miniature pastries
10. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
11. Consumers Union Urges FDA to Conduct Full Scale Safety Review of Nanoparticles in Sunscreen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoparticles May Help Attack Cancer More Directly
(Date:4/22/2017)... ... , ... The San Juan Capistrano summer camp team at the Boys and Girls ... summer camps to provide physical activities for all campers. To read the report, click ... With an increase in specialty camps that focus on what the report terms as “sitting ...
(Date:4/21/2017)... ... ... Chicago plastic surgeon, Dr. Anil R. Shah, MD , has found the ... located on the forehead usually attributed to a facial fracture. Their appearance is not ... has discovered an approach that is minimally invasive. He is an expert at this ...
(Date:4/21/2017)... City, Colo. (PRWEB) , ... April 21, 2017 , ... ... of the Flex House, the next project in the company’s esteemed VISION House demonstration ... help homeowners use exactly the amount of resources they need to live affordably and ...
(Date:4/21/2017)... VA (PRWEB) , ... April 21, 2017 , ... ... its first weeklong campaign, AWARE: A Week of Addiction and Recovery Education, from ... evidence in treating and preventing substance use disorders. , The mission of ...
(Date:4/21/2017)... Annapolis, MD (PRWEB) , ... ... ... leading accreditation organization promoting quality-based imaging practices, is seeking candidates to serve ... activities for diagnostic imaging. , “RadSite’s ultimate mission is improving image ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  CVS Pharmacy, ... today unveiled a new store design to enhance ... of healthier food, health-focused products and expanded beauty ... to help customers discover new offerings. Together with ... next evolution of the customer experience at CVS ...
(Date:4/20/2017)... Sweden , April 20, 2017 ... NEVPF) ("NeuroVive") today announced positive preclinical results ... preclinical compound for non-alcoholic steatohepatitis (NASH), in ... NV556 has previously shown ... NASH model. Today, NeuroVive,s scientists present novel ...
(Date:4/19/2017)... , April 19, 2017  IRIDEX Corporation (Nasdaq: ... release financial results for the first quarter 2017 after ... The Company,s management team will host a corresponding conference ... ET. Investors interested in listening to the ... for domestic callers or (703) 326-3030 for international callers, ...
Breaking Medicine Technology: