Navigation Links
Nanoparticles May Help Attack Cancer More Directly
Date:4/25/2009

Method tested in mice could allow more potent treatment with fewer side effects

SATURDAY, April 25 (HealthDay News) -- Nanoparticles designed to provide more direct delivery of cancer drugs to tumors have been developed by U.S. researchers.

Made from a safe, biodegradable polymer, the nanoparticles are chemically engineered to inhibit the MARK signaling pathway, which is involved in most human tumors, and to carry a higher concentration of anti-cancer drugs to a specific area, according to the scientists at Brigham and Women's Hospital and the Harvard-MIT Division of Health Sciences and Technology.

By inhibiting the MARK signaling pathway, the nanoparticles hinder the multiplication of cancer cells and make the cells more susceptible to chemotherapy drugs. The researchers also modified the polymer used in the nanoparticles to increase drug loading 20-fold to overcome what they describe as a current drawback in nanomedicine -- low efficiency of drug loading.

"Current chemotherapy drugs must be administered in high concentration throughout the body in order to destroy tumor cells, translating to high toxicity and discomfort for the patient, mainly due to the effects on normal cells," co-lead author Rania Harfouche said in a Brigham and Women's news release.

The new nanoparticles would "allow for lower drug concentrations to be used, and provide opportunity for more potent treatments with lesser side-effects for the patient," Harfouche said.

In lab tests, nanoparticles loaded with the cancer drug cisplatin prevented the growth of cancerous skin and lung cells and also triggered cell death. When used in mice, the drug-loaded nanoparticles inhibited tumor growth, the researchers reported.

The research was published online in this week's issue of the Proceedings of the National Academy of Sciences.

"The nanoparticles target pathways involved in multiple cancer types and can be applied to a diverse set of cancers, including hard-to-treat cancers, such as breast, pancreatic and liver cancer," senior author Shiladitya Sengupta said in the news release. "The potential to add homing beacons on the surface of the nanoparticles can increase the efficiency of selectively targeting specific tumors and abolish off-target side effects."

More information

The U.S. National Cancer Institute has more about chemotherapy.



-- Robert Preidt



SOURCE: Brigham and Women's Hospital, news release, April 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Symposium to explore role nanoparticles may play in disease
3. Iowa State University researcher looks to use nanoparticles for food safety
4. Brown chemists create cancer-detecting nanoparticles
5. Magnetic nanoparticles: Suitable for cancer therapy?
6. Nanoparticles aid bone growth
7. Using magenetic nanoparticles to combat cancer
8. Nanoparticles + light = dead tumor cells
9. New disease-fighting nanoparticles look like miniature pastries
10. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
11. Consumers Union Urges FDA to Conduct Full Scale Safety Review of Nanoparticles in Sunscreen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanoparticles May Help Attack Cancer More Directly
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and ... women in the world, and the most handsome men, look naturally attractive. Plastic ...
(Date:6/24/2016)... ... 24, 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. ... service members that have been wounded in battle and their families. Venture Construction Group ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
Breaking Medicine Technology: