Navigation Links
Nanoparticle 'smart bomb' targets drug delivery to cancer cells
Date:2/12/2009

Researchers at North Carolina State University have successfully modified a common plant virus to deliver drugs only to specific cells inside the human body, without affecting surrounding tissue. These tiny "smart bombs" - each one thousands of times smaller than the width of a human hair - could lead to more effective chemotherapy treatments with greatly reduced, or even eliminated, side effects.

Drs. Stefan Franzen, professor of chemistry, and Steven Lommel, professor of plant pathology and genetics, collaborated on the project, utilizing the special properties of a fairly common and non-toxic plant virus as a means to convey drugs to the target cells.

The researchers say that the virus is appealing in both its ability to survive outside of a plant host and its built-in "cargo space" of 17 nanometers, which can be used to carry chemotherapy drugs directly to tumor cells. The researchers deploy the virus by attaching small proteins, called signal peptides, to its exterior that cause the virus to "seek out" particular cells, such as cancer cells. Those same signal peptides serve as "passwords" that allow the virus to enter the cancer cell, where it releases its cargo.

"We had tried a number of different nanoparticles as cell-targeting vectors," Franzen says. "The plant virus is superior in terms of stability, ease of manufacture, ability to target cells and ability to carry therapeutic cargo."

Calcium is the key to keeping the virus' cargo enclosed. When the virus is in the bloodstream, calcium is also abundant. Inside individual cells, however, calcium levels are much lower, which allows the virus to open, delivering the cancer drugs only to the targeted cells.

"Another factor that makes the virus unique is the toughness of its shell," Lommel says. "When the virus is in a closed state, nothing will leak out of the interior, and when it does open, it opens slowly, which means that the virus has time to enter the cell nucleus before deploying its cargo, which increases the drug's efficacy."

The researchers believe that their method will alleviate the side effects of common chemotherapy treatments, while maximizing the effectiveness of the treatment.


'/>"/>

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Developing a modular, nanoparticle drug delivery system
3. ULURU Inc. Announces Issuance of Notice of Allowance for Nanoparticle Aggregate Patent
4. Gold nanoparticle probes may allow earlier cancer detection
5. Symposium to explore role nanoparticles may play in disease
6. Iowa State University researcher looks to use nanoparticles for food safety
7. Brown chemists create cancer-detecting nanoparticles
8. Magnetic nanoparticles: Suitable for cancer therapy?
9. Nanoparticles aid bone growth
10. Smart bomb nanoparticle strategy impacts metastasis
11. Nanoparticle Stops Cancer From Spreading
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... LA (PRWEB) , ... October 12, 2017 , ... Planet ... in the U.S., announced today its plans to open a flagship location in Covington, ... occupy the former Rooms To Go store next to Office Depot in the Holiday ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... 2017  NDS received FDA 510(k) clearance in May 2017 for ... stand specifically designed for endoscopy environments. An innovative secondary monitor solution, ... solution to support the improvement of patient outcomes, procedural efficiency, and ... ... ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, ... more than $100 billion in purchasing power, today announced ... and information. The Newsroom is the online ... industry trends, infographics, expert bios, news releases, slideshows and ... access to a wealth of resources at their fingertips, ...
(Date:10/4/2017)... 2017  South Korean-based healthcare product Development Company I.M. ... on Kickstarter. The device will educate the user about ... better efficiency compared to the dated and pricey CPR ... efficacy of the compression for a more informed CPR ... to raise $5,000. ...
Breaking Medicine Technology: