Navigation Links
Nanoparticle Stops Cancer From Spreading
Date:7/11/2008

'Smart bomb' curbs metastasis with fewer side effects, study finds

FRIDAY, July 11 (HealthDay News) -- California researchers say they have developed molecular "smart bombs" that stop pancreatic and kidney cancer from spreading in mice while causing fewer side effects and damage to healthy surrounding tissues than traditional chemotherapy.

A team from the University of California, San Diego, designed a "nanoparticle" anti-cancer drug delivery system that zooms in on a protein marker called integrin avB3, which is found on the surface of certain tumor blood vessels. The marker is tied to the development of new blood vessels and malignant tumor growth.

While the system had little impact on primary tumors, it halted the metastasis of pancreatic and kidney cancers throughout the bodies of mice. Cancer metastasis normally is much harder to treat than the primary tumor, and it usually leads to the patient's death.

The findings were published in this week's online issue of the Proceedings of the National Academy of Sciences.

According to the report, the system works with a lower dose of chemotherapy because it attacks the cancer with such precision. In most chemo treatments, the destruction of healthy tissue is a side effect as it floods the body with cancer-killing toxins.

"We were able to establish the desired anti-cancer effect while delivering the drug at levels 15 times below what is needed when the drug is used systemically," study leader David Cheresh, vice chairman of pathology at UCSD, said in a university news release. "Even more interesting is that the metastatic lesions were more sensitive to this therapy than the primary tumor."

UCSD engineers and oncologists together designed the nanoparticle -- a microscopic particle made of lipid-based polymers -- to work with the cancer-killing drug doxorubicin.

"Doxorubicin is known to be an effective anti-cancer drug but has been difficult to give patients an adequate dose without negative side effects," Cheresh said. "This new strategy represents the first time we've seen such an impact on metastatic growth, and it was accomplished without the collateral damage of weight loss or other outward signs of toxicity in the patient."

"Traditional cancer therapies are often limited or non-effective over time, because the toxic side effects limit the dose we can safely deliver to the patient," he said. "This new drug delivery system offers an important advance in treating metastatic disease."

More information

The National Cancer Institute has more about nanotechnology uses in cancer treatment.



-- Kevin McKeever



SOURCE: University of California, San Diego, Health Sciences, news release, July 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Developing a modular, nanoparticle drug delivery system
3. ULURU Inc. Announces Issuance of Notice of Allowance for Nanoparticle Aggregate Patent
4. Gold nanoparticle probes may allow earlier cancer detection
5. Symposium to explore role nanoparticles may play in disease
6. Iowa State University researcher looks to use nanoparticles for food safety
7. Brown chemists create cancer-detecting nanoparticles
8. Magnetic nanoparticles: Suitable for cancer therapy?
9. Nanoparticles aid bone growth
10. Smart bomb nanoparticle strategy impacts metastasis
11. Vaccine Stops Alzheimers Brain Tangles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... (PRWEB) , ... March 27, 2017 , ... ... the GTEC Orange facility from 8:00am-10:00am on Monday, April 3rd to commemorate the ... will be an opportunity for area-residents to celebrate two great years while also ...
(Date:3/27/2017)... ... March 27, 2017 , ... The homeowner improvement and repair market ... utilizing DIY and unlicensed contractors for renovations is also on the rise. Per a ... 2015, and of those, 42% failed to use a licensed contractor.(2) The risks associated ...
(Date:3/26/2017)... ... March 26, 2017 , ... ... the RealSelf 100 Award, a prestigious award honoring the top influencers on RealSelf—the ... find and connect with doctors and clinics. , In 2016, more than 82 ...
(Date:3/25/2017)... ... ... Norland at Swissray is pleased to announce the release of the ELITE DXA, a ... an active scan window, which is more than double that of existing bone densitometers. ... not undergo an accurate total body bone density or body composition study. The ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... military at the same time by providing Prehospital Trauma Life Support (PHTLS) course ... the world’s premier prehospital trauma education developed in cooperation with the American College ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... March 27, 2017  iCAD (Nasdaq: ICAD), an ... and radiation therapy for the early identification and ... Detection received Premarket Approval (PMA) from the U.S. ... is a first-of-its-kind, concurrent-read computer aided detection solution ... latest innovation available on the PowerLook® Breast Health ...
(Date:3/27/2017)... 27, 2017  PhaseRx, Inc. (NASDAQ: PZRX), a ... liver diseases in children, today reported financial results ... December 31, 2016 and provided an update on ... to make progress during the fourth quarter of ... our non-human primate safety study, and with our lead ...
(Date:3/24/2017)... PUNE, India , March 24, 2017 Abdominal Aortic ... reach $2,614 million by 2022, Globally, registering a CAGR of 5.1% from 2016 to ... and is projected to dominate the market during the study period. ... ... ...
Breaking Medicine Technology: