Navigation Links
Nanoparticle Stops Cancer From Spreading

'Smart bomb' curbs metastasis with fewer side effects, study finds

FRIDAY, July 11 (HealthDay News) -- California researchers say they have developed molecular "smart bombs" that stop pancreatic and kidney cancer from spreading in mice while causing fewer side effects and damage to healthy surrounding tissues than traditional chemotherapy.

A team from the University of California, San Diego, designed a "nanoparticle" anti-cancer drug delivery system that zooms in on a protein marker called integrin avB3, which is found on the surface of certain tumor blood vessels. The marker is tied to the development of new blood vessels and malignant tumor growth.

While the system had little impact on primary tumors, it halted the metastasis of pancreatic and kidney cancers throughout the bodies of mice. Cancer metastasis normally is much harder to treat than the primary tumor, and it usually leads to the patient's death.

The findings were published in this week's online issue of the Proceedings of the National Academy of Sciences.

According to the report, the system works with a lower dose of chemotherapy because it attacks the cancer with such precision. In most chemo treatments, the destruction of healthy tissue is a side effect as it floods the body with cancer-killing toxins.

"We were able to establish the desired anti-cancer effect while delivering the drug at levels 15 times below what is needed when the drug is used systemically," study leader David Cheresh, vice chairman of pathology at UCSD, said in a university news release. "Even more interesting is that the metastatic lesions were more sensitive to this therapy than the primary tumor."

UCSD engineers and oncologists together designed the nanoparticle -- a microscopic particle made of lipid-based polymers -- to work with the cancer-killing drug doxorubicin.

"Doxorubicin is known to be an effective anti-cancer drug but has been difficult to give patients an adequate dose without negative side effects," Cheresh said. "This new strategy represents the first time we've seen such an impact on metastatic growth, and it was accomplished without the collateral damage of weight loss or other outward signs of toxicity in the patient."

"Traditional cancer therapies are often limited or non-effective over time, because the toxic side effects limit the dose we can safely deliver to the patient," he said. "This new drug delivery system offers an important advance in treating metastatic disease."

More information

The National Cancer Institute has more about nanotechnology uses in cancer treatment.

-- Kevin McKeever

SOURCE: University of California, San Diego, Health Sciences, news release, July 7, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Developing a modular, nanoparticle drug delivery system
3. ULURU Inc. Announces Issuance of Notice of Allowance for Nanoparticle Aggregate Patent
4. Gold nanoparticle probes may allow earlier cancer detection
5. Symposium to explore role nanoparticles may play in disease
6. Iowa State University researcher looks to use nanoparticles for food safety
7. Brown chemists create cancer-detecting nanoparticles
8. Magnetic nanoparticles: Suitable for cancer therapy?
9. Nanoparticles aid bone growth
10. Smart bomb nanoparticle strategy impacts metastasis
11. Vaccine Stops Alzheimers Brain Tangles
Post Your Comments:
(Date:11/30/2015)... , ... November 30, 2015 , ... ... Beard and Brooke Bennett are collaborating with brands across various categories through traditional ... influential figures make up an elite group of Gold Medal Moms who can ...
(Date:11/30/2015)... ... December 01, 2015 , ... The National ... 2015-2016 inductee into its VIP Woman of the Year Circle. She is recognized ... networking organization exclusively for professional women, boasting 850,000 members and over 200 operating ...
(Date:11/30/2015)... ... 30, 2015 , ... During the National Family Caregivers Month, ... two webinars on topics of ‘Medical and Palliative Care Decisions,’ and ‘Self-Care for ... . , With a loved one's diagnosis of mesothelioma, the closest family member ...
(Date:11/30/2015)... ... November 30, 2015 , ... MOSI recently added two state-of-the-art augmented reality ... to the Jurassic to their collection of interactive exhibits within the Kids In Charge! ... will allow guests to get closer than ever to a range of animals as ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... across the United States to access life-saving information provided directly from top ... will consist of three individual conferences in three major cities: Houston, San Francisco, ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 2015 --> --> ... Market by Product (Soft Tissue, All Tissue, Dental Welding Lasers), ... and Geography - Global Forecast to 2020", published by MarketsandMarkets, ... a CAGR of 5.2% during the forecast period from 2015 ... and 62 Figures spread through 167 P ages and ...
(Date:11/30/2015)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ), a clinical-stage ... delivery systems, announced today it has signed definitive licensing ... of Technologies Co., Ltd. ("HTIT") for exclusive rights to ... China , Hong Kong ... signed at the Israel Knesset (Parliament). ...
(Date:11/30/2015)... , Nov. 30, 2015   Nuance Communications, Inc. ... National Decision Support Company (NDSC) today jointly announced ... collaboration capabilities that utilize the American College of Radiology,s ... provider organizations to comply with current and emerging ... --> By combining clinical decision support, ...
Breaking Medicine Technology: