Navigation Links
Nanomedicine system engineered to enhance therapeutic effects of injectable drugs
Date:3/3/2008

HOUSTON - (March 2, 2008) - In an article featured on the cover of the March issue of Nature Nanotechnology, Mauro Ferrari, Ph.D., of The University of Texas Health Science Center at Houston presented a proof-of-concept study on a new multistage delivery system (MDS) for imaging and therapeutic applications. This discovery could go a long way toward making injectable drugs more effective. The study is included in the March 2 Advance Online Publication on Nature Nanotechnologys Web site (http://www.nature.com/nnano/index.html)

This is next generation nanomedicine, said Ferrari, the senior author. Now, were engineering sophisticated nanostructures to elude the bodys natural defenses, locate tumors and other diseased cells, and release a payload of therapeutics, contrasting agents, or both over a controlled period. Its the difference between riding a bicycle and a motorcycle.

The study - Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications - was conducted with researchers from The University of Texas M. D. Anderson Cancer Center and Rice University.

Nanotechnology offers new and powerful tools to design and to engineer novel drug delivery systems and to predict how they will work once inside the body. The field of therapeutic nanoparticles began with tiny drug-encapsulated fat bubbles called liposomes, now commonly used in cancer clinics worldwide. Targeting molecules were later added to liposomes and other nanovectors to assist in directing them to diseased cells, Ferrari said.

Getting intravenous agents to their intended targets is no easy task. Its estimated that approximately one of every 100,000 molecules of agent reaches its desired destination. Physicians are faced with the quandary of increasing the dosage, which can lead to side effects or reducing the dosage, which can limit the therapeutic benefits.

The multistage approach, according to Ferrari, is needed to circumvent the bodys natural defenses or biobarriers, which act as obstacles to foreign objects injected in the blood stream. To overcome this problem, we hypothesized and developed a multifunctional MDS comprising stage 1 mesoporous particles loaded with one or more types of stage 2 nanoparticles, which can in turn carry either active agents or higher-stage particles. We have demonstrated the loading, controlled release and simultaneous in vitro delivery of quantum-dots and carbon nanotubes to human vascular cells, the authors write.

In addition to circumventing biobarriers, Ferraris team is working on the biochemical modifications required to efficiently deliver the MDS to a specific cancer lesion. We have preliminary data that show that we can localize a payload of diagnostic agents, therapeutic agents or combination of both to target cells. Once on site, the molecules can be released in a controlled way and then the MDS will degrade in 24 to 48 hours, be transformed into orthosilicic acid and leave no trace in the body, Ferrari said.

Lead author Ennio Tasciotti, Ph.D., senior postdoctoral fellow in the NanoMedicine Research Center at the UT Health Science Center at Houston, said the proof-of-concept study would have not been possible without a multidisciplinary effort including contributions from mathematicians, physicists, engineers, chemists and biologists.

We are dealing with objects that are in the billionth of a meter size range and to study such objects we used cutting edge technologies, Tasciotti said. The characterization of the particles was performed using scanning electron and atomic force microscopy, dynamic light scattering, fluorimetry and flow cytometry. The interaction of particles with cells was studied using fluorescence and confocal microscopy as well as a series of assays intended to determine cell viability and internalization rate of the nanoparticles.


'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert  

Related medicine news :

1. UCLA, Tokyo University nanobiotechnology symposium at UCLA to highlight advances in nanomedicine
2. St. Louis University Hospital Purchases Second CyberKnife(R) System
3. Valley Baptist Health System Leveraging TITAN Technology Partners Hosting and Managed Services
4. NutriSystem and Celebrities Team Up to Benefit the American Heart Association
5. IDC X-Series DR system selected for use in leading edge RSA clinical trial application
6. Groundbreaking Sign Chi Do Stress Management System Introduced by Dr. Anne Borik Now Available to the Public
7. Cardiva Medical, Inc. to Present Highlights of the Boomerang Catalyst(TM) II System at the Investment in Innovation (In3) West Conference on February 29, 2008 in Las Vegas, NV
8. Medication Management Systems Names New President and COO
9. RemoteScan - Scanner Connectivity Software for EMR (Electronic Medical Record) Systems
10. Brain stress system presents possible treatment
11. Plexus Systems, Inc. Names Stosz to Solutions Engineer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanomedicine system engineered to enhance therapeutic effects of injectable drugs
(Date:2/10/2016)... ... February 10, 2016 , ... Sherly Sulaiman, certified ... series of therapeutic sessions to help Los Angeles-area actors cope with rejection, improve ... The series, known as “Mindfulness for Actors and Artists,” has been featured in ...
(Date:2/10/2016)... ... February 10, 2016 , ... LaserShip, a regional parcel carrier that services ... of Eastern Michigan last Friday in order to aid in the Flint water crisis. ... include a facility located in Clio, only 15 miles away from Flint. , “We ...
(Date:2/10/2016)... California (PRWEB) , ... February 10, 2016 , ... ... are working together to expand dental health services to the developmentally disabled in ... We Care Dental’s operations to a new facility at 71-949 Highway 111, Suite ...
(Date:2/10/2016)... ... 10, 2016 , ... As part of its ongoing series of aquatic therapy ... webinar features a dynamic expert and thoughtful presentation to give attendees a better sense ... Both events are free to attend, but registration is required. , Rehabilitation ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... American Academy of Emergency Medicine , an emergency medicine professional association, ... practice management services . , The American Academy of Emergency Medicine, or AAEM, ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... YORK , Feb. 10, 2016 Immune ... biopharmaceutical company, announced today that it has filed a ... Leukemia and other cancers. --> ... treating cancer by administration of Ceplene (histamine dihydrochloride) in ... provides methods of predicting the efficacy of Ceplene and ...
(Date:2/10/2016)... , Feb. 10, 2016  The ALS Association, in partnership ... Grand Challenge to generate a biomarker to track TDP43 aggregation. ... up to a $1 million investment. ... disease that affects nerve cells in the brain and the ... initiate and control muscle movement, which often leads to total ...
(Date:2/10/2016)... 10, 2016 Convergence scenarios are ... various technologies that results in diverse solutions ... opportunities create a cyclical system where technology ... the development of new technologies. ... technology convergences, which are constantly fostering new ...
Breaking Medicine Technology: