Navigation Links
Nanomedicine breakthrough could improve chemotherapy for childhood cancer
Date:11/20/2012

In a world-first, researchers from the Australian Centre for Nanomedicine at the University of New South Wales (UNSW) in Sydney have developed a nanoparticle that could improve the effectiveness of chemotherapy for neuroblastoma by a factor of five.

Neuroblastoma is an aggressive childhood cancer that often leaves survivors with lingering health problems due to the high doses of chemotherapy drugs required for treatment. Anything that can potentially reduce these doses is considered an important development.

The UNSW researchers developed a non-toxic nanoparticle that can deliver and release nitric oxide (NO) to specific cancer cells in the body. The findings of their in vitro experiments have been published in the journal Chemical Communications.

"When we injected the chemo drug into the neuroblastoma cells that had been pre-treated with our new nitric oxide nanoparticle we needed only one-fifth the dose," says co-author Dr Cyrille Boyer from the School of Chemical Engineering at UNSW.

"By increasing the effectiveness of these chemotherapy drugs by a factor of five, we could significantly decrease the detrimental side-effects to healthy cells and surrounding tissue."

This synergistic effect between nitric oxide and chemotherapy drugs had previously been reported in other cancer cell lines, but the delivery compounds were potentially toxic and had very poor stability, or shelf life.

In contrast, the UNSW-developed nanoparticle is non-toxic and has a shelf life that has been extended from two days to more than two weeks: "Drug storage is critical and this is a substantial improvement over previous nitric oxide-carrier compounds," says Boyer.

Nitric Oxide is an important cellular signalling molecule involved in many physical and mental processes, and deficiencies have been associated with heightened susceptibility to cancer, liver fibrosis, diabetes, cardiovascular illnesses and neurodegenerative diseases.

"If we can restore nitric oxide with these nanoparticles this could have implications for all the illnesses associated with NO deficiencies, including diabetes and neurodegenerative," he says.

The key medical challenge, says Boyer, has been figuring out a way to deliver appropriate doses to specific sites within the body, without provoking an adverse reaction. The Australian Centre for Nanomedicine which crosses science, engineering and medicine is investigating multi-disciplinary solutions.

Boyer says that while biologists have experimented with nitric oxide, mixing it with cancer cells and observing the reactions, "no one has tried to develop a platform to specifically deliver nitric oxide that is, where you want it, when you want it".

The next step is to test the nanoparticle on other cell lines, such as lung and colon cancer cells, and to proceed to in vivo tests. The team also included researchers from the Children's Cancer Institute Australia based at UNSW's Lowy Cancer Research Centre.


'/>"/>
Contact: Steve Offner
s.offner@unsw.edu.au
61-293-851-583
University of New South Wales
Source:Eurekalert

Related medicine news :

1. First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
2. International Nanomedicine Conference bound for Sydney: July 2-4, 2012
3. Nanomedicines promise fewer side effects in treating cancer
4. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
5. First targeted nanomedicine to enter human clinical studies
6. Breakthrough nanoparticle halts multiple sclerosis
7. Research breakthrough could halt melanoma metastasis
8. Breakthrough treatment reduces post-surgical scarring for glaucoma patients
9. Breakthrough Brings Transparency to Male/Female Relationships
10. Trivedi Beef, LLC Announces Breakthrough Beef Industry Data without the use of Antibiotic Drugs, Hormones or Steroids
11. Ear, Nose & Throat Journal publishes research on breakthrough treatment for tonsil stones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... August 17, 2017 , ... Dr. Charles W. Grimsley’s new ... ($15.99, paperback, 9781498497626; $7.99, eBook, 9781498497633) focuses on the treatment of veterans diagnosed ... achieve forgiveness, through a progressive journey toward healing. This book will help readers ...
(Date:8/17/2017)... , ... August 17, 2017 , ... Advice Media, the industry leader in digital marketing ... in North America and has been included in the Inc. 5000 for the second time ... to be included in the Inc. 5000 rankings for the second year in a row. ...
(Date:8/16/2017)... ... August 16, 2017 , ... Summer days spent with family are priceless. ... put together suggestions for enjoying the season of sunshine. Add trying something new to ... family can join in on the fun. , Try Something New ...
(Date:8/16/2017)... ... August 16, 2017 , ... Ten outstanding teachers in the Greater ... Classroom and will win a visit by a Houston Texans player, two tickets to ... least five years old can visit texanschecking.com/stars to nominate their favorite teacher with an ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... In a ... its appearance with diet and exercise. In fact, cellulite can't always be eliminated by ... and more effective treatment available to select physicians nationwide. Dr. Kenneth Rothaus has recently ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017   Mostyn Law and Gulf Coast ... Houston, Texas . The Mostyn Law family has ... years. That is why Mostyn Law is partnering with ... to show its appreciation. Blood supplies are running low. ... short of hospital needs in August. That is why the blood ...
(Date:8/14/2017)... Israel , Aug. 15, 2017 /PRNewswire/ ... of adult stem cell technologies for neurodegenerative diseases, announced ... 2017. "We are ... Phase 3 trial to investigate NurOwn ® in ... Executive Officer of BrainStorm. "We have agreements with Mass. ...
(Date:8/7/2017)... 7, 2017 Insightin Health, provider of ... and engagement, announced the selection of Michael ... Development, effective as of February 2017. In this role, ... strategy for our clients. Wood brings with him ... and business analytics within the healthcare industry. Wood ...
Breaking Medicine Technology: