Navigation Links
Nanomedicine breakthrough could improve chemotherapy for childhood cancer
Date:11/20/2012

In a world-first, researchers from the Australian Centre for Nanomedicine at the University of New South Wales (UNSW) in Sydney have developed a nanoparticle that could improve the effectiveness of chemotherapy for neuroblastoma by a factor of five.

Neuroblastoma is an aggressive childhood cancer that often leaves survivors with lingering health problems due to the high doses of chemotherapy drugs required for treatment. Anything that can potentially reduce these doses is considered an important development.

The UNSW researchers developed a non-toxic nanoparticle that can deliver and release nitric oxide (NO) to specific cancer cells in the body. The findings of their in vitro experiments have been published in the journal Chemical Communications.

"When we injected the chemo drug into the neuroblastoma cells that had been pre-treated with our new nitric oxide nanoparticle we needed only one-fifth the dose," says co-author Dr Cyrille Boyer from the School of Chemical Engineering at UNSW.

"By increasing the effectiveness of these chemotherapy drugs by a factor of five, we could significantly decrease the detrimental side-effects to healthy cells and surrounding tissue."

This synergistic effect between nitric oxide and chemotherapy drugs had previously been reported in other cancer cell lines, but the delivery compounds were potentially toxic and had very poor stability, or shelf life.

In contrast, the UNSW-developed nanoparticle is non-toxic and has a shelf life that has been extended from two days to more than two weeks: "Drug storage is critical and this is a substantial improvement over previous nitric oxide-carrier compounds," says Boyer.

Nitric Oxide is an important cellular signalling molecule involved in many physical and mental processes, and deficiencies have been associated with heightened susceptibility to cancer, liver fibrosis, diabetes, cardiovascular illnesses and neurodegenerative diseases.

"If we can restore nitric oxide with these nanoparticles this could have implications for all the illnesses associated with NO deficiencies, including diabetes and neurodegenerative," he says.

The key medical challenge, says Boyer, has been figuring out a way to deliver appropriate doses to specific sites within the body, without provoking an adverse reaction. The Australian Centre for Nanomedicine which crosses science, engineering and medicine is investigating multi-disciplinary solutions.

Boyer says that while biologists have experimented with nitric oxide, mixing it with cancer cells and observing the reactions, "no one has tried to develop a platform to specifically deliver nitric oxide that is, where you want it, when you want it".

The next step is to test the nanoparticle on other cell lines, such as lung and colon cancer cells, and to proceed to in vivo tests. The team also included researchers from the Children's Cancer Institute Australia based at UNSW's Lowy Cancer Research Centre.


'/>"/>
Contact: Steve Offner
s.offner@unsw.edu.au
61-293-851-583
University of New South Wales
Source:Eurekalert

Related medicine news :

1. First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
2. International Nanomedicine Conference bound for Sydney: July 2-4, 2012
3. Nanomedicines promise fewer side effects in treating cancer
4. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
5. First targeted nanomedicine to enter human clinical studies
6. Breakthrough nanoparticle halts multiple sclerosis
7. Research breakthrough could halt melanoma metastasis
8. Breakthrough treatment reduces post-surgical scarring for glaucoma patients
9. Breakthrough Brings Transparency to Male/Female Relationships
10. Trivedi Beef, LLC Announces Breakthrough Beef Industry Data without the use of Antibiotic Drugs, Hormones or Steroids
11. Ear, Nose & Throat Journal publishes research on breakthrough treatment for tonsil stones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... ... Doctors on Liens is continuing its steady expansion of medical specialties throughout ... North Valley Eye Medical Group in Mission Hills . Eye injuries and vision ... cases. These injuries have a major impact on the quality of life of ...
(Date:2/22/2017)... ... February 22, 2017 , ... The first-ever ... as organizations, advocates, and individuals join together to increase recognition about the risks ... save lives. , “Today we mark a nationwide movement to raise awareness about ...
(Date:2/22/2017)... ... 22, 2017 , ... Bellus Medical, a leader in medical ... delivery of Platelet Rich Plasma (PRP). PRP systems are used by physicians in ... synthesis and provide a faster and more efficient healing process. There are many ...
(Date:2/22/2017)... ... 22, 2017 , ... The SeniorCare Investor will host an important webinar— Seniors ... 2017, at 1:00 PM ET. A recording of the webinar will also be made ... , If you want to find out what really happened in the seniors housing ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... suffer from combat-related PTSD. , Established in 1977, our organization was at the ... of military returning to civilian life were evident and served as the catalyst ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb. 22, 2017 IRIDEX Corporation ... will release financial results for the fourth quarter and ... 8, 2017.  The Company,s management team will host a ... 5:00 p.m. ET. Investors interested in listening ... (844) 707-0665 for domestic callers or (703) 326-3030 for ...
(Date:2/22/2017)... astic drugs develop from traditional single antineoplastic drug towards ... at multiple links. Research and development of antineoplastic drugs ... Download the full report: https://www.reportbuyer.com/product/4696059/ ... new tumors in China every ... industrialization and lifestyles changed by factors like urbanization, malignant ...
(Date:2/22/2017)... Summary Provides understanding and access ... agreements entered into by the worlds leading healthcare companies. ... Description The Global Non-Small Cell Lung Cancer Partnering Terms ... to partnering deals and agreements entered into by the ... partnering deals - Top deals by value ...
Breaking Medicine Technology: