Navigation Links
Nanomedicine breakthrough could improve chemotherapy for childhood cancer
Date:11/20/2012

In a world-first, researchers from the Australian Centre for Nanomedicine at the University of New South Wales (UNSW) in Sydney have developed a nanoparticle that could improve the effectiveness of chemotherapy for neuroblastoma by a factor of five.

Neuroblastoma is an aggressive childhood cancer that often leaves survivors with lingering health problems due to the high doses of chemotherapy drugs required for treatment. Anything that can potentially reduce these doses is considered an important development.

The UNSW researchers developed a non-toxic nanoparticle that can deliver and release nitric oxide (NO) to specific cancer cells in the body. The findings of their in vitro experiments have been published in the journal Chemical Communications.

"When we injected the chemo drug into the neuroblastoma cells that had been pre-treated with our new nitric oxide nanoparticle we needed only one-fifth the dose," says co-author Dr Cyrille Boyer from the School of Chemical Engineering at UNSW.

"By increasing the effectiveness of these chemotherapy drugs by a factor of five, we could significantly decrease the detrimental side-effects to healthy cells and surrounding tissue."

This synergistic effect between nitric oxide and chemotherapy drugs had previously been reported in other cancer cell lines, but the delivery compounds were potentially toxic and had very poor stability, or shelf life.

In contrast, the UNSW-developed nanoparticle is non-toxic and has a shelf life that has been extended from two days to more than two weeks: "Drug storage is critical and this is a substantial improvement over previous nitric oxide-carrier compounds," says Boyer.

Nitric Oxide is an important cellular signalling molecule involved in many physical and mental processes, and deficiencies have been associated with heightened susceptibility to cancer, liver fibrosis, diabetes, cardiovascular illnesses and neurodeg
'/>"/>

Contact: Steve Offner
s.offner@unsw.edu.au
61-293-851-583
University of New South Wales
Source:Eurekalert

Page: 1 2

Related medicine news :

1. First-of-its-kind approach nanomedicine design effectively targets cancer with decreased toxicity
2. International Nanomedicine Conference bound for Sydney: July 2-4, 2012
3. Nanomedicines promise fewer side effects in treating cancer
4. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
5. First targeted nanomedicine to enter human clinical studies
6. Breakthrough nanoparticle halts multiple sclerosis
7. Research breakthrough could halt melanoma metastasis
8. Breakthrough treatment reduces post-surgical scarring for glaucoma patients
9. Breakthrough Brings Transparency to Male/Female Relationships
10. Trivedi Beef, LLC Announces Breakthrough Beef Industry Data without the use of Antibiotic Drugs, Hormones or Steroids
11. Ear, Nose & Throat Journal publishes research on breakthrough treatment for tonsil stones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Ticketability.com has Theresa Caputo tickets for ... well-known medium has been thrilling many with her amazing ... cities, with tickets becoming available August 15. , Among ... Albany, Baltimore, Trenton, Erie, Buffalo, Philadelphia, Charlotte, Houston, New ... Diego. The medium’s fans can obtain Theresa Caputo tour ...
(Date:8/20/2014)... The “Human Insulin Market by ... Premixed), Modern Human Insulin (Rapid Acting, Long Acting, ... Tresiba, Others) - Forecast to 2019” provides a ... current market trends,and strategies impacting the global human ... of the revenue and share analysis. , Browse ...
(Date:8/20/2014)... GBK, the luxury lifestyle gift lounge and special events ... at the annual GBK Gift Lounge. This year’s event will ... from 11am – 6pm. GBK will offer guests an opportunity ... , As always, GBK will blend this award show celebration ... lounge. GO Campaign is a grantmaking organization that improves the ...
(Date:8/20/2014)... VA (PRWEB) August 20, 2014 What ... by Getting Locked Out of the Market, **FDAnews Webinar**, ... EDT, http://www.fdanews.com/DoNowforUDI , Hospitals and other buyers ... due to ineffective product tracking systems. , Complying with ... is customer demands to implement UDI as soon as ...
(Date:8/19/2014)... (PRWEB) August 20, 2014 The elegant ... people can upgrade their houses in an environmentally conscious ... made of solid materials and have an aluminum oxide ... them well suited for high-traffic areas. , Recently, the ... strand woven bamboo floorings . These fresh items are ...
Breaking Medicine News(10 mins):Health News:Theresa Caputo Tour Tickets for Sale at Ticketability.com Cause a Buying Frenzy Among Customers Over Their Offering of Deeply Discounted Seats 2Health News:Human Insulin Market by Product Types and Brand Worth $42 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Human Insulin Market by Product Types and Brand Worth $42 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Human Insulin Market by Product Types and Brand Worth $42 Billion by 2019 - New Report by MarketsandMarkets 4Health News:GBK Presents a Luxury Gift Lounge Honoring the Nominees and Presenters of the 2014 Emmy® Awards - August 22nd and 23rd - Beverly Hills 2Health News:GBK Presents a Luxury Gift Lounge Honoring the Nominees and Presenters of the 2014 Emmy® Awards - August 22nd and 23rd - Beverly Hills 3Health News:GBK Presents a Luxury Gift Lounge Honoring the Nominees and Presenters of the 2014 Emmy® Awards - August 22nd and 23rd - Beverly Hills 4Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 2Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 3Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 4Health News:BambooIndustry.com Announces Up To 30% Discount On Its New Click Strand Woven Bamboo Floorings 2
... ... on the medical step-by-step process of Gastric Banding and Roux-en-Y Gastric Banding Bariatric ... ... gain, Western Bariatric Institute, a leader in Bariatric surgery since 2000, is providing ...
... RESTON, Virginia, October 7 Ekahau Inc., the ... today announced that,Southeast Alabama Medical Center (SAMC), a ... Ekahau RTLS to include campuswide monitoring,of its refrigerators ... and Management capabilities offers proof of how,technologically advanced ...
... for Cardiothoracic Surgery have performed countless successful Lung ... diagnosis of lung cancer can be a daunting one. Swift, ... than any other type of cancer, lung cancer is indeed ... to health, a number of different treatments are considered. The ...
... Oct. 6 Speaker Nancy Pelosi and the Democratic Women,s ... outside the Capitol this afternoon to discuss how ... . Women will continue to face discrimination in both coverage ... statement and closing remarks. , On Why ...
... , - Significant variation exists in the quality of ... disease in U.S. hospitals. , - Hospitals receiving performance ... Guidelines (GWTG) quality improvement program appear to have better ... DALLAS, Oct. 6 Hospitals receiving performance awards from ...
... H1N1 virus, experts say , TUESDAY, Oct. 6 (HealthDay News) ... the pandemic H1N1 swine flu, but not enough to prevent ... , In a study of hospital patients during the H1N1 ... those who had had a seasonal flu shot and were ...
Cached Medicine News:Health News:Making Weight Loss Surgery Safer and More Effective 2Health News:Southeast Alabama Medical Center Deploys Ekahau's Wireless Temperature Management Solution 2Health News:Southeast Alabama Medical Center Deploys Ekahau's Wireless Temperature Management Solution 3Health News:The California Center for Cardiothoracic Surgery (heart411.com) Surgeons are Leaders in Lung Cancer Surgery 2Health News:Pelosi: Health Insurance Reform Essential for Women 2Health News:Pelosi: Health Insurance Reform Essential for Women 3Health News:Pelosi: Health Insurance Reform Essential for Women 4Health News:Pelosi: Health Insurance Reform Essential for Women 5Health News:American Heart Association Quality News: Commitment to Quality Results in Lower Mortality Rates for Heart Attack and Heart Failure Patients 2Health News:American Heart Association Quality News: Commitment to Quality Results in Lower Mortality Rates for Heart Attack and Heart Failure Patients 3Health News:Seasonal Flu Vaccine May Lessen Swine Flu Impact 2
(Date:8/19/2014)... -- According to Kalorama Information, electronic medical records (EMR) ... in healthcare a reality, and this a factor that ... Recovery and Reinvestment Act, the U.S. government dedicated $20.6 ... will start applying soon for use of paper records.  ... of the EMR industry, EMR 2014: The Market ...
(Date:8/19/2014)... 2014  Cardiva Medical, Inc. announced today that it ... million Series 3 private equity financing and a $12.5 ... will use the proceeds of the Series 3 private ... for its VASCADE® Vascular Closure System in ... in Series 3 private equity financing was a new ...
(Date:8/19/2014)... , Aug. 19, 2014  Regeneron Pharmaceuticals, Inc. (NASDAQ: ... conferences: , Sanofi and Regeneron will host an IR ... on Tuesday, September 2, 2014 , Baird 2014 ... September 3, 2014 , Citi,s 9 th ... Thursday, September 4, 2014 , Morgan Stanley Global ...
Breaking Medicine Technology:Kalorama: EMR Paves the Way for Big Data 2Kalorama: EMR Paves the Way for Big Data 3Cardiva Medical, Inc. Announces Completion of the first two tranches of Series 3 Private Equity Financing and the Closing of a Senior Secured Debt Facility with GE Capital 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: