Navigation Links
'Nanomachine' Releases Anticancer Drugs Inside Cells

In response to light, its pores let loose chemicals targeting disease

FRIDAY, April 4 (HealthDay News) -- A nanomachine that can kill cancer cells has been developed by researchers at the University of California, Los Angeles.

The "nanoimpeller" collects and stores anti-cancer drugs inside tiny pores and releases the drugs into cancer cells in response to light. It's the first light-powered nanomachine able to operate inside a living cell, said the team from the Nano Machine Center at the California NanoSystems Institute at UCLA.

To create the nanoimpeller, the researchers used mesoporous silica nanoparticles and coated the interiors of the pores with azobenzene, a chemical that changes characteristics when exposed to light.

Laboratory tests were conducted using a number of types of human cancer cells, including colon and pancreatic cancer cells. The nanoimpellers were loaded into the cancer cells in the dark. When light was directed at them, the nanoimpellers released their contents into the cells.

"The achievement here is gaining precise control of the amount of drugs that are released by controlling the light exposure. Controlled release to a specific location is the key issue. And the release is only activated by where the light is shining," Fuyu Tamanoi, a professor of microbiology, immunology and molecular genetics and director of the signal transduction and therapeutics group at UCLA's Jonsson Comprehensive Cancer Center, said in a prepared statement.

He and colleague Jeffrey Zink, a professor of chemistry and biochemistry, said this system "has potential applications for precise drug delivery and might be the next generation for novel platform for the treatment of cancers such as colon and stomach cancer. The fact that one can operate the mechanism by remote control means that one can administer repeated small-dosage releases to achieve greater control of the drug's effect."

The research was published online March 31 in the nanoscience journal Small.

More information

The U.S. Food and Drug Administration has more about nanotechnology products.

-- Robert Preidt

SOURCE: University of California, Los Angeles, news release, March 31, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UCLA researchers design nanomachine that kills cancer cells
2. Cleveland Clinic Press Releases Journal-Writing Book Write for Life: Healing Body, Mind, and Spirit Through Journal Writing by Sheppard B. Kominars, Ph.D.
3. Leading Child Abuse Center Releases Back to School Tips to Protect Children From Internet Predators
4. JHA Releases 2007 U.S. Group Disability Mid-Year Market Survey Results
5. Verdict One Releases Directory of Board Certified Attorneys for Consumers
6. Academy releases emergency preparedness tools to enable millions more people to shelter in place
7. Provectus Pharmaceuticals, Inc. releases summary results of phase 1 metastatic melanoma study
8. MITEM Releases Blue Iris eLaborate 8.6
9. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
10. Patient Safety Authority Releases Advisory Focusing on Common Causes of Medication Errors
11. URAC Releases Issue Briefs Examining Stakeholders Views of Care Coordination Along the Healthcare Continuum
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Element Blue ... introduced a new company, RightSensor™ LLC, an Internet of Things (IoT) hardware supplier ... provides a fully-managed approach for customers requiring sensor hardware for critical data environments. ...
(Date:10/13/2015)... ... 13, 2015 , ... Relay (, a technology company that ... significant contract that will provide its award-winning private messaging solution to Independence Blue ... success of its Relay program, IBX Wire™, which now has over 550,000 members ...
(Date:10/13/2015)... ... October 13, 2015 , ... e-con Systems Inc., a leading embedded design ... the industry’s first RGB-IR pixel format camera with a USB 3.0 interface and ... See3CAM family of UVC USB 3.0 cameras, is based on the 1/3-inch OV4682 - ...
(Date:10/13/2015)... Tenn. (PRWEB) , ... October 13, 2015 , ... A ... and that’s why SmileCareClub , the leading remote invisible aligner system, has joined ... who would otherwise go without it. For each aligner treatment plan purchased, SmileCareClub will ...
(Date:10/13/2015)... ... October 13, 2015 , ... Protein is essential to good health. You ... and blood. But how much protein does the average man need in order to ... to the October 2015 issue of Harvard Men's Health Watch . Most Americans ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015   Micell Technologies ... DESSOLVE I and II trials of its MiStent Sirolimus ... ® ) were presented at the 27th Annual ... San Francisco , October 11-15. TCT ... cardiovascular medicine. MiStent SES was designed to optimize vessel ...
(Date:10/13/2015)... -- Health Gorilla ( ) today announced the launch ... secure platform for clinical data and communications poised to change ... healthcare in the US. The launch follows the closing of ... of $4.4M raised to date, with Data Collective ... Harris Barton , Orfin Ventures and ...
(Date:10/13/2015)... 2015 China Jo-Jo Drugstores, Inc. ... "), a leading China-based retail, wholesale and online distributor ... online and retail pharmacies, announced preliminary half year fiscal ... pharmacy through , growing 438% year over ... China Jo-Jo,s online sales are ...
Breaking Medicine Technology: