Navigation Links
'Nanomachine' Releases Anticancer Drugs Inside Cells
Date:4/4/2008

In response to light, its pores let loose chemicals targeting disease

FRIDAY, April 4 (HealthDay News) -- A nanomachine that can kill cancer cells has been developed by researchers at the University of California, Los Angeles.

The "nanoimpeller" collects and stores anti-cancer drugs inside tiny pores and releases the drugs into cancer cells in response to light. It's the first light-powered nanomachine able to operate inside a living cell, said the team from the Nano Machine Center at the California NanoSystems Institute at UCLA.

To create the nanoimpeller, the researchers used mesoporous silica nanoparticles and coated the interiors of the pores with azobenzene, a chemical that changes characteristics when exposed to light.

Laboratory tests were conducted using a number of types of human cancer cells, including colon and pancreatic cancer cells. The nanoimpellers were loaded into the cancer cells in the dark. When light was directed at them, the nanoimpellers released their contents into the cells.

"The achievement here is gaining precise control of the amount of drugs that are released by controlling the light exposure. Controlled release to a specific location is the key issue. And the release is only activated by where the light is shining," Fuyu Tamanoi, a professor of microbiology, immunology and molecular genetics and director of the signal transduction and therapeutics group at UCLA's Jonsson Comprehensive Cancer Center, said in a prepared statement.

He and colleague Jeffrey Zink, a professor of chemistry and biochemistry, said this system "has potential applications for precise drug delivery and might be the next generation for novel platform for the treatment of cancers such as colon and stomach cancer. The fact that one can operate the mechanism by remote control means that one can administer repeated small-dosage releases to achieve greater control of the drug's effect."

The research was published online March 31 in the nanoscience journal Small.

More information

The U.S. Food and Drug Administration has more about nanotechnology products.



-- Robert Preidt



SOURCE: University of California, Los Angeles, news release, March 31, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UCLA researchers design nanomachine that kills cancer cells
2. Cleveland Clinic Press Releases Journal-Writing Book Write for Life: Healing Body, Mind, and Spirit Through Journal Writing by Sheppard B. Kominars, Ph.D.
3. Leading Child Abuse Center Releases Back to School Tips to Protect Children From Internet Predators
4. JHA Releases 2007 U.S. Group Disability Mid-Year Market Survey Results
5. Verdict One Releases Directory of Board Certified Attorneys for Consumers
6. Academy releases emergency preparedness tools to enable millions more people to shelter in place
7. Provectus Pharmaceuticals, Inc. releases summary results of phase 1 metastatic melanoma study
8. MITEM Releases Blue Iris eLaborate 8.6
9. Produce for Better Health Foundation Releases Statement on Study Saying Fruit & Vegetable Consumption Not Strongly Associated With Colon Cancer Risk
10. Patient Safety Authority Releases Advisory Focusing on Common Causes of Medication Errors
11. URAC Releases Issue Briefs Examining Stakeholders Views of Care Coordination Along the Healthcare Continuum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... , ... April 21, 2017 , ... ... it’s been named Agency of Record (AOR) for Theravent, Inc. , the ... snoring. Theravent’s parent company, Foundation Consumer Healthcare, is now working to expand distribution ...
(Date:4/21/2017)... ... April 21, 2017 , ... Crossover ... O2X , an active lifestyle company that provides Human Performance Training and ... firefighters, police offers, first responders, military officers and others in service through the ...
(Date:4/21/2017)... , ... April 21, 2017 , ... Alive for ... who wish to overcome their mental health struggles. The Alive team uses advanced ... says: “Our approach in dealing with a mental health struggle is based on ...
(Date:4/21/2017)... ... 21, 2017 , ... Northern California Medical Associates ... Symposium on April 1, 2017 in Santa Rosa. This well-attended annual conference plays ... an opportunity to learn about cutting edge treatments, to collaborate, share research and ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... practices, is seeking candidates to serve on its Accreditation and Standards Committees ... “RadSite’s ultimate mission is improving image quality and reducing patient radiation dose,” ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017  AbbVie (NYSE: ABBV), a global ... of chronic hepatitis C virus (HCV) infected patients ... and compensated cirrhosis (Child-Pugh A) achieved sustained virologic ... with its investigational, pan-genotypic regimen of glecaprevir/pibrentasvir (G/P). ... following 12 weeks of G/P treatment without ribavirin. ...
(Date:4/19/2017)... Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), announces that it ... 2017 at the Sheraton Hotel in Toronto, Ontario ... the Company is scheduled to present on Tuesday, May 2 at ... Chairman of the Board, Tony Holler will also attend ... For more details ...
(Date:4/19/2017)... April 19, 2017 Global Prostate Cancer ... on the prostate cancer therapeutics market analyzes the ... Increasing prevalence of prostate cancer, launch of promising ... development of new drugs & therapeutic biological products, ... due to lesser side effects are some of ...
Breaking Medicine Technology: