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Nanoemulsion vaccines show increasing promise
Date:2/26/2008

ulsion smallpox vaccine effective in people, it could be a safer way to protect citizens and health care workers in the event of a bioterrorism attack involving smallpox, Baker says.

That would allay concerns about the current vaccines safety which arose in 2002. On the eve of the Iraq War, the Bush administration proposed a voluntary program to vaccinate military personnel and 500,000 health care workers with the existing vaccine to prepare for the possible use of smallpox virus as a biological weapon.

Relatively few health care workers volunteered to get the vaccine, amid concerns that the live vaccinia virus used in the vaccine can be transmitted to other people for a time and can pose a serious risk to people with weakened immune systems and certain skin conditions. As of mid-2007, more than 1.2 million military personnel received smallpox shots. Small percentages of those vaccinated subsequently have had heart and neurological adverse effects.

Early HIV study tests mucosal immunity

Bakers team has published results from a preliminary test of a nanoemulsion vaccines effectiveness against HIV in the February issue of AIDS Research Human Retroviruses.

It is becoming widely acknowledged that standard approaches to vaccines against HIV have not worked. Baker says the HIV nanoemulsion vaccine tested in the noses of mice in the study represents a different approach in the way it produces immunity and the type of immunity produced.

Vaccines administered in the nose are also able to induce mucosal immunity in the genital mucosa. Evidence is growing that HIV virus can infect the mucosal immune system.

Therefore, developing mucosal immunity may be very important for protection against HIV, Baker says, adding that previous vaccine approaches have not aimed to do that.

In the study, the nanoemulsion HIV vaccine showed it was able to induce mucosal immunity, cellular immunity and neutralizing
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Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

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