Navigation Links
Nanoballs deliver drugs
Date:10/24/2007

Dutch researcher Cristianne Rijcken has developed a new type of biodegradable nanoparticle. The spherical structures can encapsulate various fat-soluble medicines, which makes it easier to target tumour tissue. These nanoballs are highly promising carriers for the controlled release of anticancer drugs. Rijcken recently gained her doctorate for this research from Utrecht University.

Anticancer drugs sometimes have very harmful side effects because they do not distinguish between tumours and healthy tissue. However by encapsulating these drugs in nanoparticles, they more frequently end up in the right tissue. Due to the biodegradable nature of the nanoparticles, the drug is only released once the particles break down. The breakdown period can be adjusted by using different components for the nanostructures.

Drug packages

The nanoparticles consist of polyethylene glycol (PEG) chains which are attached to recently developed components: lactic acid derivatives of polymethacrylamides. These new chains possess the unique combined property of biodegradability and heat sensitivity. By simply heating up an aqueous polymer solution, compact spherical nanoparticles smaller than 100 nanometres are spontaneously formed. The properties and life span of Rijcken's so-called ' stabilised micelles' can be completely controlled by changing the components.

Experiments have shown that various types of fat-soluble anticancer drugs could be enclosed in the core of these micelles. The enclosed substances were only released after the lactic acid groups in the polymer had been split off, causing the nanoparticles to fall apart. The stabilised nanoballs accumulated to a larger extent in the tumours of tumour-carrying mice than traditional micelles. The new nanostructures exhibited no side effects and are completely biodegradable, whereas the current products with anticancer drugs often also contain other toxic ingredients.

Further research

Further research is needed to determine the blood circulation and tumour accumulation of drug-containing micelles. Additionally, the development of new components as building blocks for the nanoparticles will allow an even more accurate regulation of the specificity and drug release.


'/>"/>

Contact: Dr. Cristianne Rijcken
c.j.f.rijcken@uu.nl
Netherlands Organization for Scientific Research
Source:Eurekalert

Related medicine news :

1. Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery
2. The Effects Of Delaying A Delivery Questioned
3. Metronidazole Increases Risk Of Premature Deliveries.
4. Early delivery can prevent cancer
5. Mothers with periodontitis may deliver premature babies
6. Most Women Unprepared for Operative Deliveries
7. Link between C-section Delivery and Stillbirth
8. Painkilling Patch As Effective As Intravenous Delivery Systems
9. New Method Of Delivering Chemotherapy
10. Post delivery antidepressants do not affect weight loss
11. Research reports that c-section deliveries are rising
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... , ... April 29, 2016 , ... Dr. Robert Mondavi, ... treatments to improve smiles. Cosmetic dentistry is a fast-growing field as more patients are ... allows patients to learn more about the options currently available to them and which ...
(Date:4/29/2016)... ... April 29, 2016 , ... Innovations with Ed Begley ... upcoming episode, airing third quarter 2016 via Discovery Channel. Dates and show times ... Dairy Products, located in Greenwood, Wisconsin applies product research and development and continuous ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... their animal line of probiotics, Petbiotics ™, as they fondly call them. ... animal rescue groups networking for their non-profit organizations. Animal rescues across the nation ...
(Date:4/29/2016)... ... April 29, 2016 , ... Intellitec ... held May 16th to 18th at the Broward County Convention Center. The event ... to collaborate on best practices in public facility management. Intellitec Solutions will highlight ...
(Date:4/29/2016)... ... April 29, 2016 , ... In its efforts of bringing ... continues its successful franchise development and expansion as it welcomes Ferdie Vasquez of the ... administrative experience in his 32 years of working in various industries. He had ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... April 28, 2016 , Net Sales of ... basis over the prior year period, and an increase of ... , Diluted EPS for the first quarter were $0.52 reported, ... $2.00 adjusted, an increase of 29.9% over the prior year ... adjusted earnings guidance for 2016 Zimmer Biomet Holdings, ...
(Date:4/28/2016)... April 28, 2016 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral drug delivery ... upcoming PIONEERS 2016 conference, presented by Joseph Gunnar ... New York . Nadav Kidron , ... conference. Presentation Details:   PIONEERS ...
(Date:4/28/2016)... Calif. , April 28, 2016 /PRNewswire/ ... Validation Lifecycle Management Solutions (VLMS) today announced ... and services for sufferers of chronic kidney ... System to manage their corporate validation process. ... seeking a software solution to manage their ...
Breaking Medicine Technology: