Navigation Links
Nanoballs deliver drugs
Date:10/24/2007

Dutch researcher Cristianne Rijcken has developed a new type of biodegradable nanoparticle. The spherical structures can encapsulate various fat-soluble medicines, which makes it easier to target tumour tissue. These nanoballs are highly promising carriers for the controlled release of anticancer drugs. Rijcken recently gained her doctorate for this research from Utrecht University.

Anticancer drugs sometimes have very harmful side effects because they do not distinguish between tumours and healthy tissue. However by encapsulating these drugs in nanoparticles, they more frequently end up in the right tissue. Due to the biodegradable nature of the nanoparticles, the drug is only released once the particles break down. The breakdown period can be adjusted by using different components for the nanostructures.

Drug packages

The nanoparticles consist of polyethylene glycol (PEG) chains which are attached to recently developed components: lactic acid derivatives of polymethacrylamides. These new chains possess the unique combined property of biodegradability and heat sensitivity. By simply heating up an aqueous polymer solution, compact spherical nanoparticles smaller than 100 nanometres are spontaneously formed. The properties and life span of Rijcken's so-called ' stabilised micelles' can be completely controlled by changing the components.

Experiments have shown that various types of fat-soluble anticancer drugs could be enclosed in the core of these micelles. The enclosed substances were only released after the lactic acid groups in the polymer had been split off, causing the nanoparticles to fall apart. The stabilised nanoballs accumulated to a larger extent in the tumours of tumour-carrying mice than traditional micelles. The new nanostructures exhibited no side effects and are completely biodegradable, whereas the current products with anticancer drugs often also contain other toxic ingredients.

Further research

Further research is needed to determine the blood circulation and tumour accumulation of drug-containing micelles. Additionally, the development of new components as building blocks for the nanoparticles will allow an even more accurate regulation of the specificity and drug release.


'/>"/>

Contact: Dr. Cristianne Rijcken
c.j.f.rijcken@uu.nl
Netherlands Organization for Scientific Research
Source:Eurekalert

Related medicine news :

1. Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery
2. The Effects Of Delaying A Delivery Questioned
3. Metronidazole Increases Risk Of Premature Deliveries.
4. Early delivery can prevent cancer
5. Mothers with periodontitis may deliver premature babies
6. Most Women Unprepared for Operative Deliveries
7. Link between C-section Delivery and Stillbirth
8. Painkilling Patch As Effective As Intravenous Delivery Systems
9. New Method Of Delivering Chemotherapy
10. Post delivery antidepressants do not affect weight loss
11. Research reports that c-section deliveries are rising
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate ... in Latin America . ... ... ... ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: