Navigation Links
Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy
Date:4/23/2012

kins Wilmer Eye Institute.

Animals treated with dendrimer-borne NAC showed marked improvement in motor control and coordination within five days after birth, nearly reaching the motor skill of healthy rabbits. By comparison, rabbits treated with dendrimer-free NAC showed minimal, if any, improvement, even at doses 10 times higher than the dendrimer-borne version. Animals treated with the dendrimer-delivered drug also showed better muscle tone and less stiffness in the hind leg muscles, both hallmarks of CP.

Brain tissue analysis revealed that rabbits treated with dendrimer-borne NAC had notably fewer "bad" microglia the inflammatory cells responsible for brain damage as well as markedly lower levels of other inflammation markers. They also had better preserved myelin, the protein that sheaths nerves and is stripped or damaged in CP and other neurologic disorders. And even though CP is marked by neuron death in certain brain centers, animals who received dendrimer-borne NAC had higher number of neurons in the brain regions responsible for coordination and motor control, compared with untreated animals and those treated with NAC only.

The findings suggest that the treatment not only reduces inflammation in the cells, but may also prevent cell damage and cell death, the researchers said. The Kannans, who are married, say they plan to follow some treated animals into adulthood to ensure the improvements are not temporary.

A separate study, led by Rangaramanujam Kannan, has already demonstrated the therapeutic benefits of this approach in reversing retinal damage in rats with macular degeneration, the vision-robbing eye disorder that affects millions of older adults.


'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Independence Blue Cross teams with American College of Physicians to improve primary care
2. Care for Mentally Ill Vets at VA Centers May Differ Across U.S.
3. Project leads next decade of aging research across Europe
4. Project leads next decade of ageing research across Europe
5. After Stroke, Crossed Legs a Welcome Sign
6. Kids With ADHD Less Adept at Crossing the Street: Study
7. New hospital mortality rate index to be used across UK
8. 24th ECNP Congress: The most promising data from research across brain disorders
9. States vary in childrens health, gaps exist in insurance, quality care across sectors
10. Leading experts call for urgent action to avoid stroke crisis across Asia-Pacific region
11. Childrens doctors team up across state lines to fight disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... Dr. Amy Reed, who together with her husband, ... use of power morcellators ( http://www.morcellatorlawsuit2015.com ) in uterine ... the launch of their public health campaign. The couple told ... mother of six had recently undergone surgery to remove a ... Reed had been in remission for about a year after ...
(Date:3/6/2015)... Greenwood Village, CO (PRWEB) March 06, 2015 ... reducing infant mortality around the world is traveling to ... meet with survivors of their malnutrition program. , This ... the same region in Angola, demonstrating their commitment to ... five and under. The team will engage with the ...
(Date:3/6/2015)... 2015 Follow us on LinkedIn ... and crowns, abutments and dentures are used to provide ... teeth and missing teeth. The growth in the global ... by an aging global population, expanding number of edentulous ... the 65+ population being edentulous or completely toothless, there ...
(Date:3/6/2015)... 06, 2015 US Sports Football Camps ... camps – two non-contact specialty camps and one contact ... Perfect Performance Training, located at Bowie State University and ... position specific skills, speed and strength of football athletes. ... University with Marvin Graves, former quarterback in the Canadian ...
(Date:3/6/2015)... 2015 Since Medicare began paying for ... has been an overwhelming demand from providers for straightforward ... CCM program. The Centers for Medicare & Medicaid ... , PYA’s updated white paper—“ Providing and Billing Medicare ... a detailed, yet practical “how to” manual for providers ...
Breaking Medicine News(10 mins):Health News:Power Morcellator News: Bernstein Liebhard LLP Comments on Report that Physician Working to Ban Uterine Morcellation Has Cancer Recurrence 2Health News:Power Morcellator News: Bernstein Liebhard LLP Comments on Report that Physician Working to Ban Uterine Morcellation Has Cancer Recurrence 3Health News:Power Morcellator News: Bernstein Liebhard LLP Comments on Report that Physician Working to Ban Uterine Morcellation Has Cancer Recurrence 4Health News:Saving Moses Returns to Angola to Continue Giving Infants and Children a Chance to Live 2Health News:Aging Population & Emphasis on Dental Care Drives the Dental Prosthetic & Implant Consumables Market, According to a New Report by Global Industry Analysts, Inc. 2Health News:Aging Population & Emphasis on Dental Care Drives the Dental Prosthetic & Implant Consumables Market, According to a New Report by Global Industry Analysts, Inc. 3Health News:US Sports Camps to Host Three New Football Camps in Maryland 2Health News:Updated PYA White Paper Meets Demand for Guidance on Providing and Billing Medicare for Chronic Care Management 2
... , , Medtronic Featured as Official ... The American Association of Heart Failure Nurses (AAHFN) is ... February 8-14 .   , The purpose of Heart Failure Awareness ... common and debilitating condition.  AAHFN will achieve this goal through the ...
... but effective treatment, experts say , FRIDAY, Feb. 5 ... can be killed by a type of bacteria that ... maggots to disinfect wounds (maggot debridement therapy) is standard ... dead tissue and ingest bacteria that are killed in ...
... responsible for ,pending epidemic, researchers say , FRIDAY, Feb. ... patients but can cause work-related injuries in surgeons, suggests ... Medicine researchers found that 87 percent of laparoscopic surgeons ... physical symptoms or discomfort. , "We face a pending ...
... NEW YORK , Feb. 5 Hospital for ... today announced its support of the Arthritis Foundation and Ad ... raise awareness of osteoarthritis, increase public health education and support ... our extensive clinical and research resources on raising awareness of ...
... , , BEIJING, CHINA , Feb. 5 ... attention to a certain previously released news announcements namely January 7 ... January 12,2010 , and January 22, 2010 . , These ... these events are now starting to crystallize and are beginning to transform ...
... more likely to misuse prescribed drugs, suffer flareups ... patients who use herbal remedies experience increased symptoms and ... Researchers followed 326 asthma patients for 33 months. Of ... and used prescribed inhaled corticosteroids (ICS) less often than ...
Cached Medicine News:Health News:AAHFN Promotes Heart Failure Awareness Week Through Webinar 2Health News:Wound-Healing Maggots Succumb to Deadly Bacteria 2Health News:HSS Supports Arthritis Foundation Focus on Raising National Awareness of Osteoarthritis 2Health News:HSS Supports Arthritis Foundation Focus on Raising National Awareness of Osteoarthritis 3Health News:HSS Supports Arthritis Foundation Focus on Raising National Awareness of Osteoarthritis 4Health News:Hard to Treat Diseases (HTDS) Update On Various Business Developments Evaluations and Proposals 2Health News:Hard to Treat Diseases (HTDS) Update On Various Business Developments Evaluations and Proposals 3Health News:Hard to Treat Diseases (HTDS) Update On Various Business Developments Evaluations and Proposals 4Health News:Hard to Treat Diseases (HTDS) Update On Various Business Developments Evaluations and Proposals 5Health News:Herbals Not the Answer for Asthma, Study Shows 2
(Date:3/6/2015)... Del. , March 6, 2015 ... and Trademark Office,s publication of U.S. Patent Application ... Disorder."  The ,249 Patent Application features claimed methods of ... be used to treat Binge Eating Disorder (,BED,)," ... material," or "flyer or an advertisement," as well ...
(Date:3/5/2015)... BioLineRx (NASDAQ: BLRX ; ... identifying, in-licensing and developing promising therapeutic candidates, today ... offering of American Depositary Shares ("ADSs"), each representing ... the ADSs in the offering are to be ... is acting as sole book-running manager for the ...
(Date:3/5/2015)... -- IRIDEX Corporation (Nasdaq: IRIX ) today reported financial ... 2015.  , Revenues were $11.8 million in the ... up 11% from $10.6 million in the 2013 fourth quarter. ... 12% from $38.3 million in 2013. , Gross margin ... in the fourth quarter of the prior year. , ...
Breaking Medicine Technology:Lucerne Biosciences Announces Publication of Claimed Methods for Treating Binge Eating Disorder with Lisdexamfetamine Dimesylate 2BioLineRx Announces Underwritten Public Offering of its American Depositary Shares 2BioLineRx Announces Underwritten Public Offering of its American Depositary Shares 3IRIDEX Reports 2014 Fourth Quarter, Year-End Results 2IRIDEX Reports 2014 Fourth Quarter, Year-End Results 3IRIDEX Reports 2014 Fourth Quarter, Year-End Results 4IRIDEX Reports 2014 Fourth Quarter, Year-End Results 5IRIDEX Reports 2014 Fourth Quarter, Year-End Results 6IRIDEX Reports 2014 Fourth Quarter, Year-End Results 7IRIDEX Reports 2014 Fourth Quarter, Year-End Results 8
... step in the evolution of the ... to use, easy to learn ETT ... standard tube, as well as a ... handle intubations of difficult airways, without ...
Indications For Usage: ,Facilitates intubation of tracheal tubes....
Indications For Usage: ,Microlaryngeal surgery....
... the early onset of VAP. (Valles J, ... aspiration of subglottic secretions in preventing ventilator-associated ... Mahul P, Auboyer C, Jospe R, et ... patients: respective role of mechanical subglottic secretions ...
Medicine Products: