Navigation Links
Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy
Date:4/23/2012

ptoms and improving quality of life, but can neither reduce nor reverse neurologic damage and loss of motor function.

Neuro-inflammatory damage occurs when two types of brain cells called microglia and astrocytes normally deployed to protect the brain during infection and inflammation actually damage it by going into overdrive and destroying healthy brain cells along with damaged ones.

Directly treating cells in the brain has long proven difficult because of the biological and physiological systems that have evolved to protect the brain from blood-borne infections. The quest to deliver the drug to the brain also involved developing a technique to get past the brain-blood barrier, spare healthy brain cells and deliver the anti-inflammatory drug exclusively inside the rogue cells.

To do all this, the scientists used a globular, tree-like synthetic molecule, known as a dendrimer. Its size 2,000 times smaller than a red blood cell renders it fit for travel across the blood-brain barrier. Moreover, the dendrimer's tree-like structure allowed scientists to attach to it molecules of an anti-inflammatory NAC. The researchers tagged the drug-laced dendrimers with fluorescent tracers to monitor their journey to the brain and injected them into rabbits with cerebral palsy six hours after birth. Another group of newborn rabbits received an injection of NAC only.

Not only did the drug-loaded dendrimers make their way inside the brain but, once there, were rapidly swallowed by the overactive astrocytes and microglia.

"These rampant inflammatory cells, in effect, gobbled up their own poison," Kannan says.

"The dendrimers not only successfully crossed the blood-brain barrier but, perhaps more importantly, zeroed in on the very cells responsible for neuro-inflammation, releasing the therapeutic drug directly into them," says senior investigator Rangaramanujam Kannan, Ph.D., of the Center for Nanomedicine at the Johns Hop
'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Independence Blue Cross teams with American College of Physicians to improve primary care
2. Care for Mentally Ill Vets at VA Centers May Differ Across U.S.
3. Project leads next decade of aging research across Europe
4. Project leads next decade of ageing research across Europe
5. After Stroke, Crossed Legs a Welcome Sign
6. Kids With ADHD Less Adept at Crossing the Street: Study
7. New hospital mortality rate index to be used across UK
8. 24th ECNP Congress: The most promising data from research across brain disorders
9. States vary in childrens health, gaps exist in insurance, quality care across sectors
10. Leading experts call for urgent action to avoid stroke crisis across Asia-Pacific region
11. Childrens doctors team up across state lines to fight disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Familylifeinsurancequotes.org has released a new blog ... citizens. , Senior citizens can qualify for affordable ... to seniors who are over 50 years old. Some ... a medical examination. , Term life insurance with a ... can qualify. Having life insurance during retirement is important ...
(Date:10/1/2014)... CA (PRWEB) October 01, 2014 Bedros ... Fit Body Boot Camp fitness boot camps, he’s also ... personal training , with sold out business summits, a ... as marketing consultant to a recent Spike TV reality ... says that now is the time for personal trainers ...
(Date:10/1/2014)... Hillsboro, Oregon (PRWEB) October 01, 2014 ... curing solutions , continues to expand the business worldwide. ... engineering along with additional capacity for manufacturing efforts. The ... over the last five years and expects this growth ... UV LED curing technology gains worldwide adoption. , ...
(Date:10/1/2014)... MO (PRWEB) October 01, 2014 Join the ... Castlewood Eating Disorder Treatment Center’s first ever charity golf tournament ... for people with eating disorders who cannot afford treatment. The ... Golf Club in Eureka, Mo. , The day-long event ... noon. A reception and award dinner will begin at 5 ...
(Date:10/1/2014)... October 01, 2014 Between 23 million ... the U.S., according to figures from the National Institutes ... Association (AARDA), and many of them have something else ... having undiagnosed celiac disease. Gluten Free Therapeutics, makers ... of undiagnosed celiac disease by publishing a series of ...
Breaking Medicine News(10 mins):Health News:Affordable Term Life Insurance - Senior Citizens Can Qualify for Coverage! 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 3Health News:Phoseon Technology Continues to Drive Growth Worldwide 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3
... Financial contracts to care for sick or aging relatives ... new interest as everyday Americans wrestle with the time and ... legal expert says. , Law professor Richard L. Kaplan says ... a groundswell, and most people still bristle at the notion ...
... 27 Warner Chilcott Limited (Nasdaq: WCRX ) ... has filed for standard review the new drug application (NDA) ... NDA for WC 3016 was submitted by its subsidiary, Warner ... Warner Chilcott , Warner Chilcott is a leading ...
... Today, the Children,s Health Fund (CHF) announced a ... support a new health care clinic in the South ... Starr International Foundation grant will support the clinic,s medical ... The homeless health care clinic is part of the ...
... Inc. (OTC Bulletin Board: NVLX), an emerging healthcare ... distribute Infinitink (the world,s first permanent tattoo ink ... Zealand. The distribution agreement grants Jayhur Enterprises (Sydney, ... market, distribute and sell ...
... Kandahar, Afghanistan could help surgeons prepare for civilian disasters, ... two tours at the hospital. Dr. Vivian McAlister ... the Schulich School of Medicine & Dentistry at The ... the London Health Sciences Centre. He spent two months ...
... can lead to healthier livesST. LOUIS, May 27 ... rollout a new consumer health tool that will complement ... customers. Nurse Response will offer the Healthwise Knowledgebase, an ... Response consumers to access over 7,000 health topics online. ...
Cached Medicine News:Health News:Contracts adding legal twist to family health care 2Health News:Contracts adding legal twist to family health care 3Health News:Warner Chilcott Announces FDA Acceptance of NDA Submission for Low Dose Oral Contraceptive 2Health News:Warner Chilcott Announces FDA Acceptance of NDA Submission for Low Dose Oral Contraceptive 3Health News:Children's Health Fund Receives $500,000 from the Starr International Foundation to Support South Bronx Homeless Health Care Clinic 2Health News:Nuvilex Signs Agreement with Jayhur Enterprises to Distribute Infinitink - the World's First Permanent, But Easier to Remove Tattoo Ink - in Australia and New Zealand 2Health News:Nuvilex Signs Agreement with Jayhur Enterprises to Distribute Infinitink - the World's First Permanent, But Easier to Remove Tattoo Ink - in Australia and New Zealand 3Health News:Sharing surgical lessons from the Canadian field hospital in Afghanistan 2
(Date:9/30/2014)... 2014 STUDY OBJECTIVES The objective ... provide an overview of the current and future ... The key objective is to present a comprehensive ... an important tool in the treatment of various ... strategies within the protein therapeutics market, which includes ...
(Date:9/30/2014)... 30, 2014 Aileron Therapeutics, Inc. - ... Global Markets Direct,s, ,Aileron Therapeutics, Inc. - Product ... the Aileron Therapeutics, Inc.,s pharmaceutical research and development ... the current therapeutic developmental pipeline of Aileron Therapeutics, ... therapeutics assessment by drug target, mechanism of action ...
(Date:9/30/2014)... Group finds that the Asia Pacific dental ... , India , Japan ... implant procedure volumes will grow as physicians are increasingly trained on ... findings from Decision Resources Group,s coverage of the Asia ... implant penetration: Penetration of dental implants among the Asia ...
Breaking Medicine Technology:Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 4Aileron Therapeutics, Inc. - Product Pipeline Review - 2014 2Aileron Therapeutics, Inc. - Product Pipeline Review - 2014 3Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3
... International Corporation (NASDAQ: PRXL ), a leading ... provide a live webcast of its Investor Day on ... p.m. (EDT). All interested parties are invited ... von Rickenbach, Chief Financial Officer Jim Winschel and five ...
... - Atu027, a First in Class RNAi Therapy, Demonstrates ... Possible Biomarker Identified Silence Therapeutics to Announce New ... At 2012 ASCO Annual Meeting Silence Therapeutics plc ... interference (RNAi) therapeutics company, today announces that top line data ...
Cached Medicine Technology:Parexel Invites Public To Listen To Live Webcast Of Its Investor Day May 31, 2012 2New Data from Silence's Atu027 Anticancer Trial Published at ASCO 2New Data from Silence's Atu027 Anticancer Trial Published at ASCO 3New Data from Silence's Atu027 Anticancer Trial Published at ASCO 4New Data from Silence's Atu027 Anticancer Trial Published at ASCO 5
... Our popular Back-Aid Apron ... improved Universal Back-Saver Belt that ... take more weight off your ... shoulder strap redistribute weight from ...
Freedom of movement - plus full circle, maximum radiation protection. No other full circle radiation protection design approaches the level of comfort of the VestSkirt, which divides weight between t...
... Cryo System is the first in portability and performance. ... surgeons who need a flexible, portable system with the ... CTU attaches easily to an "E" size tank and ... cryo to where it is needed.,The CTU Travel Case ...
... System is an easy-to-use, workflow-based system designed to ... Inspirex consists of the SleepWorks software and either ... and durable systems can be used for a ... - including full EEG recording - and have ...
Medicine Products: