Navigation Links
Naked mole-rats may hold clues to pain relief
Date:9/21/2012

Naked mole-rats evolved to thrive in an acidic environment that other mammals, including humans, would find intolerable. Researchers at the University of Illinois at Chicago report new findings as to how these rodents have adapted to this environment.

The study was published online this week on PLOS ONE.

In the tightly crowded burrows of the African naked mole-rats' world, carbon dioxide builds up to levels that would be toxic for other mammals, and the air becomes highly acidic. These animals freely tolerate these unpleasant conditions, says Thomas Park, professor of biological sciences at UIC and principal investigator of the study -- which may offer clues to relieving pain in other animals and humans.

Much of the lingering pain of an injury, for example, is caused by acidification of the injured tissue, Park said.

"Acidification is an unavoidable side-effect of injury," he said. "Studying an animal that feels no pain from an acidified environment should lead to new ways of alleviating pain in humans."

In the nose of a mammal, specialized nerve fibers are activated by acidic fumes, stimulating the trigeminal nucleus, a collection of nerves in the brainstem, which in turn elicits physiological and behavioral responses that protect the animal -- it will secrete mucus and rub its nose, for example, and withdraw or avoid the acidic fumes.

The researchers placed naked mole-rats in a system of cages in which some areas contained air with acidic fumes. The animals were allowed to roam freely, and the time they spent in each area was tracked. Their behavior was compared to laboratory rats, mice, and a closely related mole-rat species that likes to live in comfy conditions, as experimental controls.

The naked mole-rats spent as much time exposing themselves to acidic fumes as they spent in fume-free areas, Park said. Each control species avoided the fumes.

The researchers were able to qu
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Could the Naked Mole Rat Hold Secrets to Longevity?
2. Genes of Africas Khoe-San Peoples Give Clues to Human Evolution
3. Clues to Ancient Dentistry Found in Human Tooth
4. HIF gene mutation found in tumor cells offers new clues about cancer metabolism
5. New genetic clues to why most bone marrow transplant patients develop graft-versus-host disease
6. Human Airways Brush Mechanism Gives Clues to Lung Diseases
7. More clues about why chimps and humans are genetically different
8. New Clues to How Alcohol May Boost Cancer Risk
9. Genetic Studies Give Clues to Tourette Syndrome, OCD
10. Why Women Outlive Men: Fruit Flies Give Clues
11. New Clues to How HIV Infects Bodys Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Bariatric Eating, a leading supplier of ... will be introducing three additional flavors to its Inspire ... additional flavors include: , Inspire Summer Melon - Natural ... Pomegranate Razz Berry -­ Pomegranate, razz and other berries ... , Bariatric Eating's Inspire protein powders use ...
(Date:7/28/2014)... Amy Norton HealthDay ... Tonsillectomies are commonly done to relieve sleep apnea in children, ... kids, weight gain -- especially if they,re already overweight. ... risk factor for a range of health problems -- including, ... kids who need it. Instead, they said, doctors and ...
(Date:7/28/2014)... dopamine-producing regions in the brain was able to arouse ... In the August issue of Anesthesiology , ... anesthetized with continuous doses of either agent would move, ... to electrical stimulation delivered to the ventral tegmental area ... the substantia nigra, did not induce the animals to ...
(Date:7/28/2014)... Southwestern Medical Center cancer researchers have found a ... activity of a mutated cancer gene common in ... (SML), interferes with the KRAS gene, or Kirsten ... proteins called K-Ras that influence when cells divide. ... dividing uncontrollably and turning cancerous. These mutations ...
(Date:7/28/2014)... July 28, 2014 Mirena IUD lawsuits ... device caused some users to suffer serious injuries after ... uterus continue to mount in U.S. courts, Bernstein Liebhard ... issued last month in New Jersey, at least 924 ... multicounty litigation underway in Bergen County Superior Court. Some ...
Breaking Medicine News(10 mins):Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2Health News:Tonsillectomy for Sleep Apnea May Trigger Weight Gain 2Health News:Tonsillectomy for Sleep Apnea May Trigger Weight Gain 3Health News:Stimulation of brain region restores consciousness to animals under general anesthesia 2Health News:UTSW cancer researchers identify irreversible inhibitor for KRAS gene mutation 2Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 3Health News:Mirena IUD Lawsuit Filings Exceed 920 in New Jersey Litigation, Bernstein Liebhard LLP Reports 4
... Colonic lipomas have been found in related literature. One ... 14 issue of the World Journal of Gastroenterology because ... discussed age and sex factors, clinical and histopathological findings, ... and previously available literature. , The article reported ...
... Food and Drug Administration (FDA) has awarded the ... $1 million Orphan Products Development grant to study ... skin or internal organs., The unique, interdisciplinary, and ... Drolet, M.D., professor of dermatology and pediatrics, at ...
... Researchers at the Board of Governors Gene Therapeutics Research ... first time that it is possible to sustain therapeutic ... to a year, even in the presence of an ... humans. , The researchers demonstrated in an animal ...
... to be a multi-stage, multi-mechanism process by animal and ... Helicobacter pylori (H pylori) in the formation of gastric ... on November 7 in the World Journal of Gastroenterology ... H pylori on gastric cancer. , Gap junctions ...
... long-term outcomes, researchers say , THURSDAY, Oct. 25 (HealthDay News) ... peptide (ANP) can lessen cardiac injuries after heart attack and ... a Japanese study in this week,s issue of The ... damaged heart muscle (infarct) and lessened what,s known as "reperfusion ...
... 26 AMICAS, Inc (Nasdaq: AMCS ),announces the following Webcast: ... Inc Webcast, When: November 1, 2007 @ 8:30 AM ... over the Internet -- Simply log on to the web at ... Contact: Lisa Gould of AMICAS, Inc, 617-779-7892. If you ...
Cached Medicine News:Health News:The largest colonic lipoma to date 2Health News:Medical College of Wisconsin receives FDA grant 2Health News:Medical College of Wisconsin receives FDA grant 3Health News:Helicobacter pylori inhibits intercellular communication of cultured gastric cells 2
(Date:7/28/2014)... Reportlinker.com announces that a new market ... Portugal Pharmaceuticals and Healthcare Report Q3 ... Includes 3 FREE quarterly updates ... last quarter has led us to revise our ... previously, BMI expects Portugal,s ...
(Date:7/28/2014)... CLEVELAND , July 28, 2014  Surgical ... new members to its Business Advisory Board. New ... Senior Vice President for Business Development and New ... (Jim) Fulton , former Senior Vice President and ... unit. Surgical Theater applies flight simulation technology to ...
(Date:7/28/2014)... , July 28, 2014  Serco Inc., a ... the Company has been awarded a re-compete contract ... (NEMSCOM) and its Deployable Medical Systems.  Serco will ... personnel to provide world-class healthcare to meet warfighter ... across the globe. The five year contract has ...
Breaking Medicine Technology:Portugal Pharmaceuticals and Healthcare Report Q3 2014 2Portugal Pharmaceuticals and Healthcare Report Q3 2014 3Portugal Pharmaceuticals and Healthcare Report Q3 2014 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 5Serco Awarded $22.7 Million Contract to Support Deployable Medical Systems 2
... , ATLANTA, Dec. 23 MiMedx Group, Inc. ... launched its first product, Paradis Vaso Shield(TM). In April ... for use as a cover for vessels following anterior vertebral ... hydrogel product protected by multiple patents and patent applications, as ...
... FRANCISCO, Dec. 23 Jennerex Biotherapeutics, a clinical-stage biotherapeutics company developing ... that management will present at the following upcoming investor conferences. , ... January 12, 2010, 9:40 a.m. PT, ... OneMedForum 2010, Wednesday, January 13, 2010, ...
Cached Medicine Technology:MiMedx Group Announces Launch of its Paradis Vaso Shield(TM) Device 2MiMedx Group Announces Launch of its Paradis Vaso Shield(TM) Device 3
...
... Bio-Rad isotopic anemia ... and minimal ,pipetting steps ... information about the processes ... and the benefit to ...
The MESACUP ANA Test Kit is a semi-quantitative enzyme-linked immunosorbent assay,(ELISA) for the detection of specific anti-nuclear antibodies in human serum as an aid in,the determination of autoim...
... a patented HEp-2 cell line that has ... to SS-A/Ro autoantibodies, without affecting the other ... been published worldwide on the HEp-2000 ANA ... autoantibodies when used in place of standard ...
Medicine Products: