Navigation Links
NYUCD awarded $2.2 million NIH grant to decode genome of caries-causing bacteria
Date:11/3/2011

Severe early childhood caries can destroy most of a child's teeth by age three, and disproportionately affects underserved populations, including American Indians and Alaskan natives. Although the link between Lactobacilli bacteria (Lb) and severe early childhood caries has been known for almost a century, progress in delineating which of 140 Lb species are responsible for the disease has remained elusive.

The recent development of whole genome sequencing has made it much easier to identify destructive bacteria. Now, an New York University dental research team has received a four-year, $2.2 million dollar grant from the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (NIH), to use whole genome sequencing to identify those strains of Lb that contribute to the development of severe early childhood caries.

The study's principal investigators, Dr. Page W. Caufield, professor of cariology and comprehensive care, and Dr. Yihong Li, professor of basic science and craniofacial biology, will analyze several hundred bacteria samples from children with severe early childhood caries and their parents, and from caries-free children and their parents. Sampling and collection will take place at Bellevue Hospital Center in New York.

Sequencing will be conducted by co-investigators at University College in Ireland and at the Wellcome Trust Sanger Institute in the United Kingdom. Drs. Caufield and Li will collaborate with experts on bacterial genome evolution at the American Museum of Natural History to identify sequences common to children with severe early childhood caries and to their parents.

Earlier research led by Drs. Caufield and Li identified virulent strains of Streptoccocus mutans, another group of bacteria commonly associated with severe early childhood caries. Dr. Caufield, a microbiologist and infectious disease specialist, and Dr. Li, a molecular epidemiologist, demonstrated that these bacteria are transmitted from mother to infant during intimate contact.

"The findings from our new study, as well as the earlier research on Streptoccocus mutans, will help propel the development of a diagnostic test that dentists can administer chairside to identify those at risk," said Dr. Caufield.

"Severe early childhood caries is one of the most prevalent chronic diseases in underprivileged populations," added Dr. Li. "Much still needs to be learned about how the disease develops, and how it can be prevented. Our study will help to fill those gaps."

Co-investigators on the Lb study include Dr. Silvia Argimon, research scientist in cariology and comprehensive care; Dr. Charles Larsen, clinical assistant professor of pediatric dentistry, Dr. Untray T. Brown, clinical associate professor of pediatric dentistry; Dr. Robert Norman, research associate professor of epidemiology & health promotion; and Dr. Peter Catapano, Jr., clinical associate professor of pediatric dentistry, all of the NYU College of Dentistry. Dr. Catapano is also a clinical associate professor of pediatrics at the NYU School of Medicine and director of the pediatric dental clinic at Bellevue Hospital Center.

Additional co-investigators include Dr. Paul O'Toole, senior scientist at University College, Ireland; Dr. Julian Parkhill, senior scientist at the Wellcome Trust Sanger Institute; Dr. Rob Desalle, curator of the Sackler Institute for Comparative Genomics of the American Museum of Natural History; and Dr. Paul J. Planet, a research associate at the American Museum of Natural History and a fellow in the pediatric infectious disease division of the Columbia College of Physicians and Surgeons Children's Hospital of New York.

Drs. Caufield and Li are also focusing on how severe early childhood caries affects children living on American Indian reservations. They are participating in a series of outreaches to Indian reservations, under the auspices of the American Dental Association, and will incorporate their observations into the NIH study.


'/>"/>

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University
Source:Eurekalert

Related medicine news :

1. BUSM researcher awarded 2 NIH grants totaling over $11 million
2. National Jewish Health researchers awarded $13 million to evaluate treatments for toxic gases
3. OU professors awarded $2.8 million for 4-year study on biodiversity in warmer climates
4. UIC awarded $14 million to study tobacco pricing and media
5. Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
6. LSUHSC awarded NIH grant to develop pneumonia vaccine
7. Cothenius Medal awarded to Arizona State University social insect scientist for lifes work
8. Penn veterinarian Ralph Brinster awarded National Medal of Science
9. Lung cancer research team awarded $1.43 million to study cancer in Eastern Kentucky
10. UT awarded NIH grants to study prevention and treatment of neurodegenerative and vascular diseases
11. Major grant awarded for HIV prevention study in Africa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s ... design of the shoulder pad. The shoulder pad provides optimal support and full ... while using cold therapy. By utilizing ice and water that is circulated from an ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s ... the 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... (HLA), the nation's first interactive health literacy software tool, and the Cancer Patient ... aspects of cancer patient education, today announce a new strategic alliance. , ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... at the University of California Berkeley, and other leading institutions in announcing the ... power of institutions to change the way animals are raised for food. , ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
Breaking Medicine Technology: