Navigation Links
NYU researchers develop compound to block signaling of cancer-causing protein
Date:7/17/2011

Researchers at New York University's Department of Chemistry and NYU Langone Medical Center have developed a compound that blocks signaling from a protein implicated in many types of cancer. The compound is described in the latest issue of the journal Nature Chemical Biology.

The researchers examined signaling by receptor tyrosine kinase (RTK). Abnormal RTK signaling is a major underlying cause of various developmental disorders and diseases, including many forms of cancer. RTK signaling pathway employs interactions between proteins Sos and Ras, and accounts for a broad range of molecular changes that underlie various cancers and other diseases. Disrupting the Sos-Ras interaction, then, is crucial to stemming the production of cancer cells.

However, interactions between large protein molecules such as Ras and Sos have been difficult to modulate with artificial means. Through a series of experimental and computational analyses, the scientists hypothesized that by mimicking a key portion of Sos, they might disrupt its interactions with Ras. Specifically, they observed that Sos activates Ras through a helixa critical portion of Sos that makes contact with Ras. Creation of this Sos mimetic required a method for locking correct helical shapes in synthetic strings of amino acids a method previously developed at NYU School of Medicine.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Page: 1

Related medicine news :

1. Mayo researchers: Genetic mutation linked to Parkinsons disease
2. Researchers Closer to Developing Universal Meningitis B Vaccine
3. Novel Virus Jumped From Monkeys to Humans, Researchers Find
4. Dentists can identify people with undiagnosed diabetes, Columbia researchers show
5. UAB researchers present a study on the psychological adaptation of adopted children
6. Researchers identify key role of microRNAs in melanoma metastasis
7. A change of heart: Penn researchers reprogram brain cells to become heart cells
8. Researchers identify early biomarker for future atopy in asymptomatic children
9. Berkeley Lab researchers apply NMR/MRI to microfluidic chromatography
10. Leeds researchers test benefit of fish oil in bowel cancer spread
11. Fox Chase researchers identify new mechanism used by cells to reverse silenced genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... As health ... medicine known as “patient engagement.” The patient is doing more than filling out a ... , “There is an increasing emphasis in health care and research on the ...
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... ... 13, 2017 , ... Many families have long-term insurance that covers care for ... a waiver for care if the client has a cognitive impairment diagnosis. , ... care, is often waived, so the benefits from their insurance start immediately,” said Mechell ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Diplomat Pharmacy, ... 8th Day Software and Consulting, LLC , and named ... 8th Day Software, based in Tennessee , ... 8th Day expands EnvoyHealth,s service offerings for health care ... "In an interoperable ...
(Date:10/2/2017)... The Rebound mobile app is poised to become a vital ... prescription drug addiction. The app empowers users to develop an ... their dosage in a safe, controlled manner while maximizing well-being. ... 100,000 people to sign up will enjoy 3 months of ... ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. ... big data solutions, today announced that its MyDario product is expected to ... TV listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, ... ...
Breaking Medicine Technology: