Navigation Links
NYU researchers develop compound to block signaling of cancer-causing protein
Date:7/17/2011

Researchers at New York University's Department of Chemistry and NYU Langone Medical Center have developed a compound that blocks signaling from a protein implicated in many types of cancer. The compound is described in the latest issue of the journal Nature Chemical Biology.

The researchers examined signaling by receptor tyrosine kinase (RTK). Abnormal RTK signaling is a major underlying cause of various developmental disorders and diseases, including many forms of cancer. RTK signaling pathway employs interactions between proteins Sos and Ras, and accounts for a broad range of molecular changes that underlie various cancers and other diseases. Disrupting the Sos-Ras interaction, then, is crucial to stemming the production of cancer cells.

However, interactions between large protein molecules such as Ras and Sos have been difficult to modulate with artificial means. Through a series of experimental and computational analyses, the scientists hypothesized that by mimicking a key portion of Sos, they might disrupt its interactions with Ras. Specifically, they observed that Sos activates Ras through a helixa critical portion of Sos that makes contact with Ras. Creation of this Sos mimetic required a method for locking correct helical shapes in synthetic strings of amino acids a method previously developed at NYU School of Medicine.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Page: 1

Related medicine news :

1. Mayo researchers: Genetic mutation linked to Parkinsons disease
2. Researchers Closer to Developing Universal Meningitis B Vaccine
3. Novel Virus Jumped From Monkeys to Humans, Researchers Find
4. Dentists can identify people with undiagnosed diabetes, Columbia researchers show
5. UAB researchers present a study on the psychological adaptation of adopted children
6. Researchers identify key role of microRNAs in melanoma metastasis
7. A change of heart: Penn researchers reprogram brain cells to become heart cells
8. Researchers identify early biomarker for future atopy in asymptomatic children
9. Berkeley Lab researchers apply NMR/MRI to microfluidic chromatography
10. Leeds researchers test benefit of fish oil in bowel cancer spread
11. Fox Chase researchers identify new mechanism used by cells to reverse silenced genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... PORT RICHEY, Fla. (PRWEB) , ... March 27, ... ... U.S. drug overdose deaths soared 167%,(1) with opioids alone responsible for over 33,000 ... Assemblyman Kevin McCarty has sponsored Assembly Bill (AB) 1512, which proposes a tax ...
(Date:3/25/2017)... ... March 25, 2017 , ... Getting earned media coverage meaningful for Garden ... , All through the year, Garden Media aims to provide material helpful to clients’ ... and pitching client’s key messages to gain coveted media placements, Garden Media ...
(Date:3/24/2017)... NY (PRWEB) , ... March 24, 2017 , ... ... “Fighting Infection,” which will spark a conversation on the current obstacles facing infection ... number of completely preventable deaths caused by these infections. , The print ...
(Date:3/24/2017)... Texas (PRWEB) , ... March 24, 2017 , ... According ... Office score is invalid because it does not obey the rules Congress has directed ... full-time equivalent jobs, which the GOP reform would restore. Yet, it estimates a reduction ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... Arizona’s Premier Center for Shamanic Healing and Spiritual Awakening, proudly presents her ... 9--24, 2017. This sacred and spiritual journey during the Summer Solstice will ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... SAN DIEGO , March 24, 2017  GenomeDx ... (Genomics Resource Information Database) and Decipher® Prostate Cancer Classifier ... Annual European Association of Urology (EAU) Congress held March ... . The Annual EAU Congress is ... and most comprehensive research in the urological field. ...
(Date:3/24/2017)... , March 23, 2017  HealthMine surveys with ... 2017 revealed that health plan members want help from ... to stay engaged in their health, 2) help closing ... integrated platform for health and 5) relevant, real-time guidance. ... and lowering healthcare costs. A ...
(Date:3/24/2017)...  Provectus Biopharmaceuticals, Inc. (OTCQB: PVCT, www.provectusbio.com ... and dermatology biopharmaceutical company, today disclosed terms of ... (the "Definitive Financing") it entered into on March ... who are referred to in the Definitive Financing ... with the Securities and Exchange Commission.   ...
Breaking Medicine Technology: