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NYU and NYU Langone researchers devise method for enhancing CEST MRI
Date:4/29/2013

nd colleagues created a non-invasive imaging technique for glycosaminogycans (GAGs), which are molecules that serve as the building blocks of cartilage and are involved in numerous vital functions in the human body. Here, under chemical exchange, they separated out the GAG protons from those of water, creating an inherent contrast agent. Testing the idea in tissue samples, the researchers found that the available GAG protons provided an effective type of contrast enhancement, allowing them to readily monitor GAGs through a clinical MRI scanner.

In the Scientific Reports work, the researchers again focused on improving visibility of GAGs through MRI. But, in this effort, they sought to block the signaling impact of the macromolecules that obscure the observation of GAGs.

To do so, they took advantage of macromolecules' broad frequency spectruma trait that allows for easy detection and neutralization. Specifically, the researchers could, in effect, "bleach" the signal out by simultaneously using multiple irradiation frequencies. As a result, macromolecular interference diminished and enhanced the quantitative assessment of GAGs.

"This method gives us the opportunity to correct existing CEST methods by focusing on molecular signals of interest with much better precision than currently exists," explains Regatte.


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Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

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