Navigation Links
NYU and NYU Langone researchers devise method for enhancing CEST MRI
Date:4/29/2013

Researchers at New York University and NYU Langone Medical Center have created a novel way to enhance MRI by reducing interference from large macromolecules that can often obscure images generated by current chemical exchange saturation transfer (CEST) methods.

Their work, which appears in the Nature publishing group journal Scientific Reports, has the potential to improve MRI for cartilage as well as for brain tissue.

"We have found a way to eliminate signals of certain molecules and thereby clean up the image of parts of the body that could be used by medical professionals in order to make diagnoses," explained Alexej Jerschow, a professor in NYU's Department of Chemistry.

The study's other authors were: Ravinder Regatte, professor, Departments of Radiology and Orthopedic Surgery, NYU Langone Medical Center; Prodromos Parasoglou, a post-doctoral research fellow, and Ding Xia, an assistant research scientist, at the Center for Biomedical Imaging, Department of Radiology at NYU Langone Medical Center; and Jae-Seung Lee, an NIH research fellow, who holds appointments in NYU's Department of Chemistry and NYU Langone Medical Center.

The researchers' work aims to improve a decade-old method, chemical exchange, which has been used to enhance MRI techniques. Under this approach, scientists exploit the movement of atoms from their natural molecular structure to water in the body in order to enhance their visibility.

However, these efforts have often been hindered by the presence of macromolecules, which continue to obscure the smaller molecules that are of interest to doctors and other health-care professionals in making assessments. The macromolecules' interference is the result of two phenomena: their size and their frequencies.

Neutralizing the macro-molecular frequency interference was the focus of the NYU method reported in Scientific Reports recently.

Previously, Jerschow, Regatte, and colleagues created a non-invasive imaging technique for glycosaminogycans (GAGs), which are molecules that serve as the building blocks of cartilage and are involved in numerous vital functions in the human body. Here, under chemical exchange, they separated out the GAG protons from those of water, creating an inherent contrast agent. Testing the idea in tissue samples, the researchers found that the available GAG protons provided an effective type of contrast enhancement, allowing them to readily monitor GAGs through a clinical MRI scanner.

In the Scientific Reports work, the researchers again focused on improving visibility of GAGs through MRI. But, in this effort, they sought to block the signaling impact of the macromolecules that obscure the observation of GAGs.

To do so, they took advantage of macromolecules' broad frequency spectruma trait that allows for easy detection and neutralization. Specifically, the researchers could, in effect, "bleach" the signal out by simultaneously using multiple irradiation frequencies. As a result, macromolecular interference diminished and enhanced the quantitative assessment of GAGs.

"This method gives us the opportunity to correct existing CEST methods by focusing on molecular signals of interest with much better precision than currently exists," explains Regatte.


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related medicine news :

1. NYU Langone experts present research, clinical advances at neurosurgeons meeting
2. NYU Langone Medical Center receives $17 million gift from the Steven A. and Alexandra M. Cohen Foundation
3. NIH awards $20 million over 5 years to train next generation of global health researchers
4. Researchers develop a new cell and animal model of inflammatory breast cancer
5. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
6. Researchers Find Gene Mutations That May Be a Key to Autism
7. Researchers find evidence of banned antibiotics in poultry products
8. NJ stroke researchers report advances in spatial neglect research at AAN Conference
9. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
10. Researchers Map Brain Regions Linked to Intelligence
11. Researchers ID Genes That May Determine Mental Illness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: