Navigation Links
NYU School of Medicine announces new clinical trial for ulcerative colitis
Date:8/7/2012

New York (August 7, 2012) A new clinical trial designed to study how worm eggs may relieve symptoms of ulcerative colitis (UC) will begin enrolling patients at NYU School of Medicine's Clinical and Translational Science Institute. This unusual therapy has been used in previous clinical trials on patients with inflammatory bowel diseases, but the mechanism of action is unclear.

"The goal of this study is to understand the mechanisms that may explain why worm eggs can improve the symptoms of UC." says the study's Principal Investigator, P'ng Loke, PhD, assistant professor of microbiology. "Understanding these mechanisms may lead to new treatment strategies and also help identify people that are most likely to respond to treatment with worm eggs."

UC is a chronic disease that is characterized by open sores or ulcers in the lining of the colon. According to the Crohn's and Colitis Foundation of America, the disease is estimated to affect 700,000 Americans. Symptoms include abdominal pain and bloody diarrhea. While the cause is unknown, studies suggest that a defective response against commensal (normal microflora) gut bacteria could be responsible.

Colitis is common in North America and Northern Europe, where helminth (parasitic worm) infections are rare. Conversely, the disease is rare in Asia, Africa, and Latin America, where helminth infections are endemic, leading researchers to hypothesize that the worms offer protection against this inflammatory bowel disease. In animal models of autoimmunity these worms have suppressed inflammation, and clinical trials indicate that helminth therapy can be beneficial in relieving symptoms of inflammatory bowel diseases.

In 2005, Dr. Joel Weinstock and colleagues at the University of Iowa published a series of human studies showing that eggs from the pig whipworm Trichuris suis (TSO) had positive effects in both Crohn's disease as well as ulcerative colitis patients, which are two different types of inflammatory bowel diseases. Several large studies on TSO are underway for a number of different immune disorders.

In 2010, Dr. Loke and his colleagues reported a detailed study of a man with UC who ingested Trichuris trichiura eggs to relieve his own symptoms. Based on the samples that were analyzed from this man, the researchers hypothesized that the immune response activated to expel the parasites through increased cell turnover in the intestinal lining and increased mucus production may have improved his symptoms. They followed up these observations with a study on monkeys that showed that this response also changed the type of bacteria and reduced the amount of bacteria attached to the intestinal lining.

"We think that by altering the lining of the intestine, the worms may change the quantity and type of bacteria that are attached to the intestinal wall." says Dr. Loke. "We are now ready to test this idea in a human clinical trial."


'/>"/>
Contact: Lorinda Klein
lorindaann.klein@nyumc.org
212-404-3533
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related medicine news :

1. Sugary Sports Drinks Plentiful at U.S. Schools: Study
2. Preschool children who can pay attention more likely to finish college
3. Expert Tips May Help Kids Avoid Allergens at School
4. Signs of ADHD Evident by Preschool, Expert Says
5. CWRU School of Medicine researchers discover gene that permanently stops cancer cell proliferation
6. Shots Should Be on College Kids Back-to-School List
7. LA BioMed offers unique educational and research opportunity to local high school seniors
8. Preschool TV Habits Linked to 4th-Grade Waist Size, Fitness
9. U.S. High Schools Lax in Preventing Dating Abuse: Study
10. U.S. Schools Throwing the Book at Unhealthy Drinks
11. Kids Born Even a Little Early Have Lower School Scores: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... Rock Hill, SC (PRWEB) , ... March 22, 2017 , ... ... team, are expanding their patient base to accept new patients in need of skilled ... years of experience, India Hook Dental Care offers pediatric patients routine treatments, including cavities, ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... Last year, ... to a US Department of Agriculture report. While excess dairy can be caused ... a role. Lactose sensitivity is the inability to properly digest lactose, a sugar found ...
(Date:3/22/2017)... VA (PRWEB) , ... March 22, 2017 , ... ... asset protection assistance and financial consultations to families and business owners in the ... support for the local American Cancer Society Relay For Life event. , Each ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... planning services to regional families and business owners, is joining the Teen Recovery ... people in the area. , A growing number of Oklahoma teens and adolescents ...
(Date:3/22/2017)... Kingston, NC (PRWEB) , ... March 22, 2017 , ... ... planning assistance to families and business professionals throughout the coastal plains region, is initiating ... struggling to overcome cancer. , Dillyn was first diagnosed with leukemia on a Friday ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... 2017 TFS is pleased to announce the ... Tumaian , two global executive positions in Medical Affairs and Clinical ... Leadership Team and will report to Dr. Montse Barceló , ... ... 10 years of medical and scientific expertise gained across leading biopharmaceutical ...
(Date:3/22/2017)... March 22, 2017  As the world,s leading non-profit ... Society (LLS) has played a role in most therapies ... which are even helping patients with other cancers and ... significant investment in cutting-edge research – more than $1 ... grow with the record-breaking sum of $4.1 million raised ...
(Date:3/22/2017)... March 22, 2017 NetworkNewsWire Editorial Coverage  ... Deciphering ... differing statements by White House officials. Federal laws are at ... for medical and/or recreational use, and businesses like SinglePoint, Inc. ... (NASDAQ: CRBP), Medical Marijuana, Inc. (OTC: MJNA), Cannabis Science, Inc. ...
Breaking Medicine Technology: