Navigation Links
NYU Langone scientists find key pathway implicated in progression of childhood cancer
Date:9/13/2010

lf of T-ALL patients and current estimates suggest that the gene's regulatory influence might be implicated in nearly 90 percent of cases.

In the new study, the researchers found that Notch targeted a protein called NF-kB (short for nuclear factor kB), an important transcription factor that regulates genes involved in cell division and the immune response. Transcription factors bind to the DNA of genes, thereby activating them. Previous studies had suggested that cross talk between Notch and NF-kB occurred, but the new study reveals the molecular characters involved in the cross talk, and shows that blocking NF-kB eliminated leukemic cells carrying activating Notch mutations.

The researchers then found that the way that Notch1 can induce NF-kB signaling is by suppressing the expression of an enzyme called CYLD, a negative regulator of the NF-kB pathway. In other words, the enzyme normally shuts down the pathway of genes regulated by NF-kB.

"Presently, drugs that inhibit NF-kB are already in development and some of them are being tested in humans for inflammatory diseases," said Dr. Aifantis, "If used for patients with T-ALL leukemia, such drugs could be used alone or in combination with more established protocols like chemotherapy and radiation."


'/>"/>

Contact: Dorie Klissas
Dorie.Klissas@nyumc.org
212-404-3525
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NYU Langone offers vascular-targeted photodynamic therapy for localized prostate cancer
2. Scientists Pinpoint Area of Brain That Fears Losing Money
3. Scientists Discover How HIV Is Transmitted Between Men
4. Prevention Is Key Research Goal for Premature Babies, Scientists Say
5. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
6. Scientists find donut-shaped structure of enzyme involved in energy metabolism
7. Neuroscientists reveal new links that regulate brain electrical activity
8. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
9. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
10. Scientists Spot Genetic Fingerprints of Individual Cancers
11. Scientists Unravel Mysteries of Intelligence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... India (PRWEB) May 26, 2015 Surging ... 2015, one of the leading online health and wellness ... impact to the online community. It has proven ... people to read articles, watch videos, ask questions and ... The launch of the official Consumer Health Digest YouTube ...
(Date:5/26/2015)... 2015 Irwin Gross, M.D., Accumen, ... hospital-wide Patient Blood Management (PBM) initiative at Eastern Maine ... usage by more than 60 percent and improved patient ... detail in an article in the May 2015 edition ... perioperative red cell loss, less acute kidney injury and ...
(Date:5/26/2015)... (PRWEB) May 26, 2015 It was ... community foundation in Colorado. On Wednesday, May 13, The ... in a new era of community-based giving with its ... “Our Future in the Making,” the event celebrated the ... Denver Foundation to mobilize resources for good. , “If ...
(Date:5/26/2015)... 26, 2015 Relias Learning , ... the health and human services market, announces expansion of ... After strong attendance and participation in 2014, they will ... their annual user conference an exciting new facelift. ... come together and discuss best practices, share their expertise, ...
(Date:5/26/2015)... (PRWEB) May 26, 2015 CIO Review has ... Most Promising Pharma and Life Sciences Technology Solution Providers. The ... Pat 11 compliant solution which is applicable across the entire ... ease-of-use necessary for broad adoption. , “SIGNiX has been ... in the Pharma and Life Sciences Technology space, and we ...
Breaking Medicine News(10 mins):Health News:Consumer Health Digest Official YouTube Channel: A Reliable Source of Health Information 2Health News:Published Study: Patient Blood Management (PBM) Program Slashes Blood Use, Transfusions and Costs while Resulting in Better Patient Outcomes 2Health News:Published Study: Patient Blood Management (PBM) Program Slashes Blood Use, Transfusions and Costs while Resulting in Better Patient Outcomes 3Health News:Celebrating "Our Future in the Making" 2Health News:Celebrating "Our Future in the Making" 3Health News:Relias Learning Expands User Groups and Industry Influence 2Health News:Relias Learning Expands User Groups and Industry Influence 3Health News:CIO Review Selects SIGNiX as a 20 Most Promising Pharma and Life Sciences Technology Solution Provider in 2015 2Health News:CIO Review Selects SIGNiX as a 20 Most Promising Pharma and Life Sciences Technology Solution Provider in 2015 3
... men over age 60 suffer from a non-cancerous enlargement ... urinary tract symptoms, and those symptoms are frequent urination, ... incomplete emptying of the bladder, etc.Based on the findings ... be better than one when it comes to treating ...
... that exercise improves the cognitive performance of people with ... findings from their recent study. ,Researchers studied 33 ... program after having bypass surgery, angioplasty or other procedures ... better emotionally and mentally after working out with or ...
... , Asian investigators suggest physicians should not recommend dexamethasone ... therapy routinely given to newborns to prevent or treat ... cognitive functioning by school age.Previous research shows dexamethasone, a ... the short-term and allows for early weaning from mechanical ...
... million Americans are allergic to fish and shellfish and ... is reported by 2.3 percent of the general population, ... a recent study researchers found about 2.3 percent of ... allergic to seafood. Researchers interviewed more than 5,500 households ...
... Coalition of Health for Asthmatics in Sports and Exercise and the ... to 127, 6- to 18-year olds who had at ... a 10-item questionnaire. The most common risk factor noted by children ... test, kids ran for eight to 10 minutes. Forced expiratory volume ...
... by Germany researchers shows young breast cancer survivors may ... As patients may not be getting the appropriate therapy ... ,Researchers sampled nearly 200 breast cancer patients who ... their physical symptoms and current therapy treatments. Results showed ...
Cached Medicine News:
(Date:5/26/2015)... NEWARK, Calif. , May 26, 2015 Depomed, ... be presenting at two healthcare conferences in June. ... The presentation at the Jefferies conference is scheduled for 3:00 ... The 2015 JMP Securities Life Sciences Conference in ... scheduled for 11:30 am EDT (8:30 am PDT) Wednesday, June ...
(Date:5/26/2015)... ST. LOUIS , May 26, 2015   ... specialty biopharmaceutical company, today announced that it has extended ... Awards program to July 31, 2015. The program awards ... therapeutic areas. The Mallinckrodt Research Fellowship Awards ... fellows and their education. The program will award a ...
(Date:5/26/2015)... May 26, 2015   Generational Equity , a ... is pleased to announce the acquisition of its client, ... Spokane, Washington , by Mi-Med Supply ... April 30, 2015. Peaks & Plains ... region, selling medical, incontinent, nutritional, patient care, and housekeeping ...
Breaking Medicine Technology:Depomed To Present At Healthcare Conferences In June 2Mallinckrodt Extends Deadline For 2015 Research Fellowship Program 2Mallinckrodt Extends Deadline For 2015 Research Fellowship Program 3Generational Equity Announces the Acquisition of Peaks & Plains Inc. by Mi-Med Supply 2
... and AMSTERDAM, August 10, 2011 Agendia, ... the 12th St. Gallen International Breast Cancer Conference (2011) ... - classifying patients by the particular biological subtype of ... cancer patients. According to the panel, "it is no ...
... is unpredictable and can be even more so when you ... sneezing or itchy, watery eyes just might earn you top ... Facebook.  Allergy sufferers are invited to upload a short video ... win $5,000 toward a fun-filled adventure where they can enjoy ...
Cached Medicine Technology:International St. Gallen Expert Panel Highlights Importance of Molecular Subtyping in Breast Cancer Treatment 2International St. Gallen Expert Panel Highlights Importance of Molecular Subtyping in Breast Cancer Treatment 3Allegra® and Survivor Winner Danni Boatwright Want to Hear About Your "Allergy Adventures" 2Allegra® and Survivor Winner Danni Boatwright Want to Hear About Your "Allergy Adventures" 3Allegra® and Survivor Winner Danni Boatwright Want to Hear About Your "Allergy Adventures" 4
For traditional abdominoplasty, Lipectomy of abdomen...
Ideal for abdominal procedures...
... creates a smoother fit in the abdominal ... The padded continuous hook and eye closures ... the extra strong, yet very thin zipper ... a reinforced open crotch, gripper lace trim, ...
For lipoplasty of trochanteric region, abdomen, thighs, hips/flanks, buttocks & knees...
Medicine Products: