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NYU Langone Medical Center's tip sheet to the 44th annual meeting of ASCO
Date:5/16/2008

The following news tips are based on abstracts or poster presentations at the annual meeting of the American Society of Clinical Oncology (ASCO) to be held in Chicago, Illinois, May 30 June 3, 2008.

Study Tracks a Biomarker for Early Detection of Malignant Pleural Mesothelioma

Abstract # 11074: Plasma osteopontin is an early detection and prognostic marker in malignant pleural mesothelioma
NYU Cancer Institutes Harvey Pass, M.D., professor of cardiothoracic surgery and surgery; division chief of thoracic surgery and thoracic oncology, at NYU Langone Medical Center

NYU Langone Medical Center researchers and their colleagues are making strides to find a way to reliably screen for pleural mesothelioma, which threatens an estimated 7.5 million workers in the United States who have been exposed to asbestos. The level of osteopontin (OPN), a protein biomarker, in blood serum has been characterized as an early sign of pleural mesothelioma, a cancer of the chest cavity and lungs that is caused by exposure to asbestos. But recent assays have shown that plasma OPN levels are a more reliable indicator of this type of cancer. Researchers from NYU Langone Medical Center, Karmanos Cancer Institute, and University of Hawaii Cancer Center present a study showing that plasma OPN levels are a sensitive biomarker. They measured OPN levels in blood plasma of 39 mesothelioma patients and 79 asbestos-exposed individuals; plasma OPN levels appeared a sensitive discriminator for the development of pleural mesothelioma in these high-risk individuals.

Finding Novel Biomarkers for Mesothelioma with MicroRNAs

Abstract # 11027
NYU Cancer Institutes Harvey Pass, M.D., professor of cardiothoracic surgery and surgery; division chief of thoracic surgery and thoracic oncology, at NYU Langone Medical Center

Differential microRNA expression in pleural mesothelioma: Implications for early detectio
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Contact: Jennifer Berman
Jennifer.Berman@nyumc.org
212-404-3555
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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