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NYU Langone Medical Center cardiologists present at ACC 60th Annual Scientific Session
Date:4/5/2011

Cardiologists from the Cardiac & Vascular Institute at NYU Langone Medical Center presented new research findings at the American College of Cardiology 60th Annual Scientific Session held April 2-5, 2011 in New Orleans, Louisiana. Significant research findings presented by NYU Langone cardiologists included:

The Relationship between Bleeding and Mortality in Patients on Dual Antiplatelet Therapy vs. Aspirin Alone: Results from the CHARISMA Trial
Author: Jeffrey S. Berger, MD, MS, FACC, assistant professor, Medicine and director of Cardiovascular Thrombosis

Little is known about the association between bleeding and death and the actual cause of death in patients on different antiplatelet agents. Researchers investigated the association between bleeding and mortality to assess whether this association differs in patients on dual antiplatelet therapy (DAPT) versus aspirin alone. Researchers examined the association between moderate or severe bleeding and all-cause, cardiovascular and cancer mortality in 15,603 patients with cardiovascular disease or multiple risk factors enrolled in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance trial (CHARISMA). The study shows patients with moderate or severe bleeding had a higher incidence of all-cause, cardiovascular and cancer mortality. After multivariable adjustment, moderate/severe bleeding remained independently associated with not only all-cause mortality but cancer mortality as well. There was a significant interaction between bleeding and potency of antiplatelet therapy for all-cause, cardiovascular, and cancer mortality. In subjects on aspirin alone, moderate/severe bleeding was associated with all-cause, cardiovascular, and cancer mortality, but not in subjects on dual antiplatelet therapy. The study shows in stable patients, moderate or severe bleeding is associated with a significantly increased risk of all-cause, cardiovascular
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Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3753
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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