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NYU Langone Medical Center awarded $4.5 million for breast cancer research
Date:4/20/2011

te the results to a clinical trial.

Researchers will test in clinical trial the efficiency of a novel antibody to neutralize TGFβ, a protein that controls cancer cell proliferation. The TGFβ inhibitor will target the breast cancer tumor's microenvironment to enhance sensitivity to radiation while stimulating an antitumor response in a patient's immune system. The goal of the study is to test whether by irradiating a metastatic site in combination with an antibody that blocks TGFβ it is possible to induce an effective anti-tumor immune response outside the radiation field in metastatic breast cancer patients. This novel concept is based on the hypothesis that radiation-induced treatment of the tumor site can vaccinate the patient against her own cancer, and enable immune rejection of tumor sites outside the radiation field.

"Our best ally in fighting cancer is our immune system," said Dr. Formenti, who leads the Breast Cancer Research Program at the NYU Cancer Institute. "We hope that the combination treatment of radiation therapy and immunotherapy by TGFβ inhibition will significantly extend survival and improve the quality of life of patients with metastatic breast cancer."

An important component of the Multi-Team Award research team's planning and implementation process will be its collaboration with breast cancer advocates and survivors from SHARE, a non-profit organization whose mission is to create a supportive community of women affected by breast or ovarian cancer and provide medical information.


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Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3753
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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