Navigation Links
NYU Langone Medical Center awarded $4.5 million for breast cancer research
Date:4/20/2011

NYU Langone Medical Center announced today the U.S. Department of Defense (DOD) Breast Cancer Research Program (BCRP) of the Office of the Congressionally Directed Medical Research Programs has awarded Silvia Formenti, MD, the Sandra and Edward Meyer Professor and Chair of the Department of Radiation Oncology a $4.5 million Multi-Team Award to conduct novel breast cancer research.

"This Multi-Team Award offers tremendous promise for new therapeutic options for patients with breast cancer and highlights the successes that may become possible through unique synergies of the outstanding team of scientists Dr. Formenti has brought together for this work," said Vivian S. Lee, MD, PhD, MBA, chief scientific officer and vice dean for Science at NYU Langone Medical Center. "The work of Dr. Formenti and her colleagues has already improved patient outcomes and with the recognition and support of the DOD, we anticipate important, high impact research breakthroughs are on the horizon."

As principal investigator, Dr. Formenti will lead a team of researchers to explore the combined effect of radiation therapy and immunotherapy in breast cancer. The study is designed to facilitate rapid translation of discovery from the laboratory to the clinic. The Multi-Team Award research team will include laboratory and clinical scientist teams with a long-standing collaboration from the NYU Cancer Institute and UCLA including Dr. Formenti, Sandra Demaria, MD, associate professor, Department of Pathology and Mary Helen Barcellos-Hoff, PhD, professor, Departments of Radiation Oncology and Cell Biology and UCLA's William McBride, MD, professor of Radiation Oncology.

Previous research by this team has demonstrated in pre-clinical models, the efficiency of combining immunotherapy, radiotherapy and the promise of introducing a TGFβ inhibitor to attack breast cancer tumors. The award will enable researchers to build upon their pre-clinical findings and translate the results to a clinical trial.

Researchers will test in clinical trial the efficiency of a novel antibody to neutralize TGFβ, a protein that controls cancer cell proliferation. The TGFβ inhibitor will target the breast cancer tumor's microenvironment to enhance sensitivity to radiation while stimulating an antitumor response in a patient's immune system. The goal of the study is to test whether by irradiating a metastatic site in combination with an antibody that blocks TGFβ it is possible to induce an effective anti-tumor immune response outside the radiation field in metastatic breast cancer patients. This novel concept is based on the hypothesis that radiation-induced treatment of the tumor site can vaccinate the patient against her own cancer, and enable immune rejection of tumor sites outside the radiation field.

"Our best ally in fighting cancer is our immune system," said Dr. Formenti, who leads the Breast Cancer Research Program at the NYU Cancer Institute. "We hope that the combination treatment of radiation therapy and immunotherapy by TGFβ inhibition will significantly extend survival and improve the quality of life of patients with metastatic breast cancer."

An important component of the Multi-Team Award research team's planning and implementation process will be its collaboration with breast cancer advocates and survivors from SHARE, a non-profit organization whose mission is to create a supportive community of women affected by breast or ovarian cancer and provide medical information.


'/>"/>

Contact: Lauren Woods
lauren.woods@nyumc.org
212-404-3753
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related medicine news :

1. NYU Langone offers vascular-targeted photodynamic therapy for localized prostate cancer
2. NYU Langone scientists find key pathway implicated in progression of childhood cancer
3. NYU Langone Medical Center receives NIH Directors Transformative Research Projects award
4. NYU Langone Department of Orthopaedic Surgery chosen to participate in joint replacement registry
5. NYU Langone offers new imaging technique to advance robotic surgery for patients
6. NYU Langone Medical Center cardiologists present at ACC 60th Annual Scientific Session
7. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
8. Medical Transcription Services and EHR Provider MxSecure Launches New Enhanced Website with Goal of Improved Physician Productivity
9. Medical Training School, Pima Medical Institute Offering First Bachelor's Degree Program
10. FDA Seeks Reduction in Radiation From Medical Scans
11. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... ... Doorknobs are for convenience, deadbolts are for security. , There are many ... an alarm system installed. But unless there is a working deadbolt lock that is ... Premier Locksmith in Killeen, TX says: “In the majority of home burglaries, intruders use ...
(Date:6/23/2017)... , ... June 24, 2017 , ... Studies show evidence ... reduce the risk of visual loss in these patients. , But how often do ... or smoking cessation to patients at risk of or with early symptoms of AMD? ...
(Date:6/23/2017)... ... ... Goodcents Deli Fresh Subs today announced the opening of a new restaurant ... Topeka, Kan. 66604 (near 21st and Gage). It is owned and operated by long-time ... in the Topeka and Bonner Springs, Kan. area. , “Goodcents has such a ...
(Date:6/23/2017)... ... June 23, 2017 , ... MD Now Urgent Care ... MD Now’s 28th facility overall and marks the urgent care center's eighth location in ... North of The Falls shopping mall. The new clinic offers a wide array of ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl Agency, ... to families and business owners in and around Lackawanna County, is joining Meals ... in the area. , Meals on Wheels of NEPA provides hand-delivered and nutritious ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... June 9, 2017 AirXpanders, Inc. (ASX: AXP) ... the design, manufacture, sale and distribution of the AeroForm® ... progress of its commercial roll-out in the ... more than one hundred (100) medical institutions and health ... offers a needle-free alternative for women who choose reconstructive ...
(Date:6/8/2017)...  Less than a month ago, amateur hackers executed ... including hospital networks, in over 150 countries. ... largest online extortion attempts ever recorded. With the increasing ... imperative that providers understand where the risks lie, and ... and many other very real cyber threats.  ...
(Date:6/8/2017)... , June 8, 2017  StatLab ... leading developer and manufacturer of diagnostic supplies ... today that Cressey & Company LP ("Cressey ... has completed a growth-focused investment in the ... majority ownership position from selling shareholder, Prairie ...
Breaking Medicine Technology: