Navigation Links
NYU Dentistry and Medicine are awarded a $840,864 collaborative grant by the Lustgarten Foundation
Date:3/26/2013

New York University College of Dentistry (NYUCD) and New York University School of Medicine (SOM) researchers have been awarded a four-year $840,864 collaborative grant by the Lustgarten Foundation to investigate a potential link between pancreatic cancer development and endogenous gut microbiota.

The co-investigators, Deepak Saxena, MS, PhD, Assistant Professor, Basic Science and Craniofacial Biology at NYUCD, and George Miller, MD, Assistant Professor; Departments of Surgery and Cell Biology at the SOM, seek to explore the links between the intestinal microbiome, Toll-like receptors (TLRs), and pancreatic cancer.

"Endogenous gut microbiota have recently been appreciated as important regulators of homeostasis in the healthy individual and contributors toward disease during microbiotic imbalance," said Saxena. "The microbiome is also emerging as a contributor to carcinogenesis in extra-pancreatic malignancies such as colon and liver cancer. However, there has been no direct link between pancreatic cancer development and endogenous gut microbiota," he noted.

There are tangential data, however, that support such an association. For example, the oral microbiome in patients with pancreatic cancer has been found to substantially differ from control subjects. Preliminary data suggest that the intestinal microbiome may be an important regulator of pancreatic cancer development in at-risk individuals.

The study proposes to:

  • Define the evolving intestinal microbiome in mice during pancreatic cancer development and progression as well as determine whether humans with pancreatic cancer harbor a distinct microbiome compared with age-matched control patients

  • Directly test whether endoluminal bacteria can affect pancreatic oncogenesis and determine whether selectively modulating the microbiome alters the rate of tumor progression

  • Test the hypothesis that luminal pathogens affect pancreatic tumorigenesis specifically via TLR ligation

"Our experiments will provide critical new information on the mechanism of pancreatic carcinogenesis in at-risk hosts and, as such, will provide guidance for pancreatic cancer prevention and possibly treatment of incipient disease," said Saxena.

"Based on our past research, we postulate that specific pathogenic gut bacteria drive pancreatic carcinogenesis in at-risk individuals via TLR activation," said Miller.

As a part of their grant, Drs. Saxena and Miller will be attending and presenting at the annual Lustgarten Scientific Conference to be held October 20-22, 2013, at the Banbury Center on Long Island NY.


'/>"/>

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University
Source:Eurekalert

Related medicine news :

1. Melbourne, Florida Dentist Retires and Passes on Her Legacy of High Quality Dentistry
2. Dr. Teddi Olszewski Joins Northampton Family and Cosmetic Dentistry in Northampton, MA
3. Midtown Dentistry releases new Dental Education Video - "WHY DENTAL IMPLANTS?"
4. Dentist Ashburn 'Best of the Best' Awarded to Belmont Dentistry for Excellence by Follow Media Consulting, Inc. in March 2013.
5. Nashville Periodontal Group Is Expanding Their Sedation Dentistry To Include Patients In Forest Hills, TN Needing Dental Anxiety Relief
6. South Charlotte Dentistry Initiates New Emphasis on Comprehensive Dental Treatment
7. Dr. Robert Barr of Barr Family Dentistry in San Jose, CA Receives Top Reviews for Painless Laser Dental Procedures
8. Dr. Daniel Strader of Dallas Designer Smiles Receives Top Reviews as Local Dallas, TX Dentist for Biological Dentistry
9. Solomon Family Dentistry Announces that They are Now Open Seven Days a Week
10. Complimentary Dental Care in Mesa, AZ - One Day Only, February 15th - VibrantDentistry
11. Inaugural issue of the NYU College of Dentistrys JADE online now
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
Breaking Medicine Technology: