Navigation Links
NYU College of Nursing receives 450 thousand dollar NIH grant to research post-breast cancer lymphedema
Date:10/27/2011

New York University College of Nursing (NYUCN) received a two-year, $452,218.00 grant from the national Institutes of Health (NIH) to research ""Proinflammatory Biomarkers and Post-Breast Cancer Lymphedema." Post-breast cancer lymphedema (LE), a syndrome of abnormal swelling and multiple distressing symptoms, is caused by injuries to the lymphatic system from cancer treatment. As advances in cancer treatment lengthen survival, LE has emerged as a high-impact long-term morbidity that profoundly impairs survivors' quality of life.

According to Fu, the purpose of this exploratory project is to prospectively examine levels and patterns of proinflammatory biomarkers and genetic variations in relation to limb volume change measured with the infra-red perometer-350S over a 12-month period in breast cancer survivors who are at risk for lymphedema.

"Among the 2.5 million breast cancer survivors in the U.S. more than 40% of them have developed lymphedema," said NYUCN Assistant Professor Mei Fu, PhD, RN, APRN-BC. "All women undergoing breast cancer treatment are at lifetime risk for lymphedema."

While removal of lymph nodes, surgery, and radiation are the major causal factors for lymphedema, cancer treatment is necessary for life-saving. Recent research has revealed that inflammation-infection and higher body mass index (BMI) are the main predictors of lymphedema besides treatment-related risk.

Unfortunately, these studies did not evaluate biomarkers known for inflammation, and thus the role of inflammation-infection in limb volume change and lymphedema development could not be ascertained.

Elevated levels of proinflammatory biomarkers have been speculated to be associated with inflammation in patients with lymphedema. Moreover, genetic variations may be one of the important factors that influence breast cancer survivors' responses to inflammatory processes and vulnerability to lymphedema, including survivors' responses to treatment-related trauma (such as surgery and radiation) and triggering factors (such as infection, burns, minor injuries, and higher BMI or obesity).

The project will employ a prospective, descriptive, and repeated-measure design. A sample of 120 women who are newly diagnosed and treated for invasive breast cancer will be recruited. Data will be collected to evaluate levels and patterns of proinflammatory biomarkers and genotypes known for inflammation in relation to limb volume change.

"This project is an important first step toward gaining necessary knowledge and insights into breast cancer survivors' susceptibility, which may help to identify survivors at higher risk based on individual survivors' biomarker patterns and genetic factors," said Fu. "Findings of the project are fundamental in developing and testing more intense and personalized interventions to prevent and treat LE among the breast cancer survivors."


'/>"/>
Contact: christopher James
christopher.james@nyu.edu
212-998-6876
New York University
Source:Eurekalert

Related medicine news :

1. Einstein College of Medicine receives $5.7 million for developmental disabilities research
2. Campus Smoking Bans May Help College Students Quit
3. City College of New York-led research could lead to wearable sensors for the blind
4. When it comes to college hookups, more is said than done
5. College Students Not Getting Enough Zs
6. College Football Players Get Bigger, Stronger With Age
7. Teens, College-Age Youth at High Risk of Suicide, Expert Says
8. College Students Missing Out on Fruits, Veggies: Survey
9. Many Military Vets in College Plagued By Thoughts of Suicide
10. Survey Suggests Sexting Rampant in College
11. Drinking until you forget leads to injuries for college kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Lori R. ... a member of ElderCounsel, a national organization of elder law and special needs planning ... laws and rules. It also provides a forum to network with elder law attorneys ...
(Date:10/13/2017)... ... 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is ... vendors and unique items from across the nation, this holiday-themed event will raise funds ... by the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
Breaking Medicine Technology: